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What is Unoprostone

Unoprostone is a synthetic analog (docosanoid) of prostaglandin F2alpha similar to latanoprost. It is a prodrug used to reduce intraocular pressure (IOP).

Twice daily application of ophthalmic unoprostone has been shown to be as effective as twice-daily timolol 0.5% in patients with open-angle glaucoma or ocular hypertension.

Unoprostone is also effective as adjunctive therapy in refractory patients. Unoprostone is shorter-acting than latanoprost, which has the advantage of once daily dosing.

Similar to latanoprost, unoprostone has been associated with chronic iris and eyelid discoloration with increased brown pigmentation. Unoprostone was FDA-approved in August 2000.

Brand Name



  • glaucoma
  • ocular hypertension

Side Effects

  • back pain
  • blepharedema
  • blepharitis
  • blurred vision
  • cataracts
  • conjunctival hyperemia
  • conjunctivitis
  • corneal deposits
  • corneal edema
  • corneal erosion
  • corneal opacification
  • cough
  • diabetes mellitus
  • diplopia
  • dizziness
  • foreign body sensation
  • headache
  • hypertension
  • hypertrichosis
  • influenza
  • insomnia
  • iridal discoloration
  • iritis
  • keratitis
  • lacrimation
  • nausea
  • ocular hemorrhage
  • ocular hypertension
  • ocular inflammation
  • ocular irritation
  • ocular pain
  • ocular pruritus
  • optic atrophy
  • palpitations
  • pharyngitis
  • photophobia
  • ptosis
  • retinal hemorrhage
  • rhinitis
  • sinusitis
  • visual impairment
  • vomiting
  • xerophthalmia
  • xerostomia

Monitoring Parameters

  • intraocular pressure


  • aphakia
  • breast-feeding
  • contact lenses
  • corneal abrasion
  • iritis
  • keratitis
  • ocular infection
  • pregnancy
  • sunlight (UV) exposure
  • uveitis


There are no drug interactions associated with Unoprostone products.

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