What is Tucatinib
Tucatinib is an oral tyrosine kinase inhibitor of HER2. It is indicated, in combination with trastuzumab and capecitabine, for treatment of patients with advanced unresectable or metastatic HER2-positive breast cancer, including patients with brain metastases, who have received one or more prior anti-HER2-based regimens in the metastatic setting.
Severe diarrhea and hepatotoxicity have been reported. Monitor liver function tests during therapy.
Advise patients to contact their health care provider if diarrhea occurs.
Brand Name
TUKYSA
Indications
- breast cancer
Side Effects
- abdominal pain
- acneiform rash
- anemia
- anorexia
- arthralgia
- diarrhea
- dysesthesia
- elevated hepatic enzymes
- epistaxis
- erythema
- exfoliative dermatitis
- hepatotoxicity
- hyperbilirubinemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypophosphatemia
- maculopapular rash
- nausea
- oral ulceration
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- peripheral neuropathy
- rash
- seizures
- stomatitis
- urticaria
- vomiting
- weight loss
Monitoring Parameters
- LFTs
- pregnancy testing
Contraindications
- breast-feeding
- contraception requirements
- hepatic disease
- hepatotoxicity
- infertility
- male-mediated teratogenicity
- pregnancy
- pregnancy testing
- renal impairment
- reproductive risk
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Ado-Trastuzumab emtansine
- Afatinib
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alosetron
- Alprazolam
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Apixaban
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Axitinib
- Azelastine; Fluticasone
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Betrixaban
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bortezomib
- Bosentan
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Cabazitaxel
- Cabozantinib
- Caffeine; Ergotamine
- Cannabidiol
- Capmatinib
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Ceritinib
- Cevimeline
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
- Cinacalcet
- Clindamycin
- Clonazepam
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Conjugated Estrogens; Medroxyprogesterone
- Copanlisib
- Crizotinib
- Cyclosporine
- Dabigatran
- Dabrafenib
- Daclatasvir
- Dapagliflozin; Saxagliptin
- Darifenacin
- Darolutamide
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deferasirox
- Deflazacort
- Dexamethasone
- Dexlansoprazole
- Dextromethorphan; Quinidine
- Diazepam
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Docetaxel
- Dofetilide
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxorubicin
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dutasteride
- Dutasteride; Tamsulosin
- Duvelisib
- Edoxaban
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Enfortumab vedotin
- Entrectinib
- Enzalutamide
- Eplerenone
- Erdafitinib
- Ergotamine
- Erlotinib
- Estazolam
- Estradiol Cypionate; Medroxyprogesterone
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Fedratinib
- Felodipine
- Fentanyl
- Flibanserin
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
- Fostamatinib
- Galantamine
- Gefitinib
- Gemfibrozil
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Istradefylline
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole
- Lansoprazole; Naproxen
- Lapatinib
- Larotrectinib
- Lefamulin
- Leflunomide
- Lemborexant
- Levomilnacipran
- Lidocaine
- Lidocaine; Prilocaine
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macitentan
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Metformin; Repaglinide
- Metformin; Saxagliptin
- Methadone
- Methylprednisolone
- Midazolam
- Midostaurin
- Mifepristone
- Mirtazapine
- Mitotane
- Modafinil
- Mometasone
- Morphine
- Morphine; Naltrexone
- Naldemedine
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nifedipine
- Nilotinib
- Nimodipine
- Nintedanib
- Nisoldipine
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Osilodrostat
- Ospemifene
- Oxybutynin
- Oxycodone
- Paclitaxel
- Palbociclib
- Panobinostat
- Paricalcitol
- Pazopanib
- Pemigatinib
- Perindopril; Amlodipine
- Pexidartinib
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pimozide
- Ponatinib
- Prednisolone
- Prednisone
- Primidone
- Propafenone
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Regorafenib
- Repaglinide
- Retapamulin
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rilpivirine
- Rimegepant
- Riociguat
- Ripretinib
- Ritonavir
- Rivaroxaban
- Roflumilast
- Romidepsin
- Ruxolitinib
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Selumetinib
- Sildenafil
- Silodosin
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Solifenacin
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Talazoparib
- Tamsulosin
- Tazemetostat
- Telithromycin
- Temsirolimus
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Teriflunomide
- Tezacaftor; Ivacaftor
- Thiotepa
- Ticagrelor
- Tinidazole
- Tipranavir
- Tofacitinib
- Tolterodine
- Tolvaptan
- Topotecan
- Toremifene
- Trabectedin
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triamcinolone
- Triazolam
- Ubrogepant
- Ulipristal
- Umeclidinium; Vilanterol
- Upadacitinib
- Valbenazine
- Vardenafil
- Vemurafenib
- Venetoclax
- Verapamil
- Vilazodone
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Vinorelbine
- Vorapaxar
- Voriconazole
- Voxelotor
- Warfarin
- Zaleplon
- Zanubrutinib
- Ziprasidone
- Zolpidem
