Smallpox and Monkeypox Vaccine Live Nonreplicating

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What is Smallpox and Monkeypox Vaccine Live Nonreplicating

Smallpox and monkeypox vaccine, live, nonreplicating is a vaccine approved for the prevention of smallpox and monkeypox disease in adults at high risk for infection.

Smallpox and monkeypox vaccine, live, nonreplicating does not contain the viruses that cause smallpox virus (variola) or monkeypox, but instead is made from a vaccinia virus. 

Brand Name

JYNNEOS

Indications & Dosage

  • monkeypox prophylaxis
  • variola (smallpox) prophylaxis

For variola (smallpox) prophylaxis and monkeypox prophylaxis in persons who are at high risk for smallpox or monkeypox infection

Side Effects

  • chills
  • erythema
  • fatigue
  • fever
  • headache
  • injection site reaction
  • nausea
  • palpitations
  • pruritus
  • sinus tachycardia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acquired immunodeficiency syndrome (AIDS)
  • agammaglobulinemia
  • breast-feeding
  • corticosteroid therapy
  • human immunodeficiency virus (HIV) infection
  • hypogammaglobulinemia
  • immunosuppression
  • intramuscular administration
  • intravenous administration
  • leukemia
  • lymphoma
  • neoplastic disease
  • pregnancy
  • radiation therapy
  • severe combined immunodeficiency (SCID)

Interactions

  • Abatacept
  • Adalimumab
  • Aldesleukin, IL-2
  • Alefacept
  • Alemtuzumab
  • Alkylating agents
  • Alpha interferons
  • Altretamine
  • Anakinra
  • Anthracyclines
  • Antimetabolites
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Axicabtagene Ciloleucel
  • Azathioprine
  • Baricitinib
  • Basiliximab
  • Belatacept
  • Belimumab
  • Bexarotene
  • Blinatumomab
  • Brodalumab
  • Busulfan
  • Canakinumab
  • Carmustine, BCNU
  • Certolizumab pegol
  • Chlorambucil
  • Cisplatin
  • Clofarabine
  • Cortisone
  • Cyclophosphamide
  • Cyclosporine
  • Cytarabine, ARA-C
  • Dacarbazine, DTIC
  • Daclizumab
  • Deflazacort
  • Dexamethasone
  • Docetaxel
  • Dupilumab
  • Efalizumab
  • Emapalumab
  • Estramustine
  • Etanercept
  • Everolimus
  • Fingolimod
  • Floxuridine
  • Fludrocortisone
  • Fluorouracil, 5-FU
  • Folate analogs
  • Golimumab
  • Guselkumab
  • Hydrocortisone
  • Ifosfamide
  • Imatinib
  • Infliximab
  • Interferon Gamma-1b
  • Ixabepilone
  • Ixekizumab
  • Leflunomide
  • Lenalidomide
  • Lomustine, CCNU
  • Mechlorethamine, Nitrogen Mustard
  • Melphalan
  • Methylprednisolone
  • Mitoxantrone
  • Muromonab-CD3
  • Mycophenolate
  • Natalizumab
  • Nelarabine
  • Nilotinib
  • Obinutuzumab
  • Ocrelizumab
  • Ofatumumab
  • Ozanimod
  • Paclitaxel
  • Prednisolone
  • Prednisone
  • Procarbazine
  • Purine analogs
  • Rilonacept
  • Risankizumab
  • Rituximab
  • Rituximab; Hyaluronidase
  • Sarilumab
  • Secukinumab
  • Siltuximab
  • Siponimod
  • Sirolimus
  • Streptozocin
  • Tacrolimus
  • Temozolomide
  • Temsirolimus
  • Teriflunomide
  • Thiotepa
  • Tildrakizumab
  • Tisagenlecleucel
  • Tocilizumab
  • Tofacitinib
  • Tositumomab
  • Triamcinolone
  • Ustekinumab
  • Vedolizumab
  • Venetoclax
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine

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