Trifluoperazine

What is Trifluoperazine

Trifluoperazine is a piperazine phenothiazine that is structurally similar to perphenazine, prochlorperazine, and fluphenazine.

It is used to treat psychotic disorders and schizophrenia.

A 5 mg trifluoperazine dose would be equivalent to 100 mg of chlorpromazine, the prototype antipsychotic.

Trifluoperazine was approved by the FDA in 1958. All dosage forms of the branded product, Stelazine® products were discontinued by the manufacturer in December 2003; however, generic products are still commercially available in the United States.

Brand Name

Stelazine

Indications

• behavioral or psychological symptoms of dementia
• generalized anxiety disorder (GAD)
• schizophrenia

Side Effects

1. agranulocytosis
2. akathisia
3. amenorrhea
4. anaphylactoid reactions
5. anemia
6. angina
7. angioedema
8. anorexia
9. aplastic anemia
10. appetite stimulation
11. asphyxia
12. atopic dermatitis
13. blurred vision
14. bradycardia
15. breast enlargement
16. bronchospasm
17. cardiac arrest
18. cerebral edema
19. cholestasis
20. constipation
21. contact dermatitis
22. corneal opacification
23. dizziness
24. drowsiness
25. dysphagia
26. dystonic reaction
27. ejaculation dysfunction
28. eosinophilia
29. erythema
30. exfoliative dermatitis
31. fatigue
32. fever
33. galactorrhea
34. glycosuria
35. gynecomastia
36. headache
37. hemolytic anemia
38. hepatitis
39. hyperglycemia
40. hyperhidrosis
41. hyperprolactinemia
42. hypersalivation
43. hypertension
44. hyperthermia
45. hypoglycemia
46. hyponatremia
47. hypotension
48. hypothermia
49. ileus
50. impotence (erectile dysfunction)
51. infertility
52. insomnia
53. jaundice
54. laryngeal edema
55. lethargy
56. leukopenia
57. libido decrease
58. lupus-like symptoms
59. mastalgia
60. menstrual irregularity
61. miosis
62. myasthenia
63. mydriasis
64. nasal congestion
65. nausea
66. neuroleptic malignant syndrome
67. neutropenia
68. orthostatic hypotension
69. pancytopenia
70. peripheral edema
71. photosensitivity
72. polydipsia
73. polyuria
74. pruritus
75. pseudoparkinsonism
76. psychosis
77. purpura
78. QT prolongation
79. retinopathy
80. seborrhea
81. seizures
82. SIADH
83. sinus tachycardia
84. skin hyperpigmentation
85. stroke
86. tardive dyskinesia
87. thrombocytopenia
88. torsade de pointes
89. urinary retention
90. urticaria
91. ventricular tachycardia
92. visual impairment
93. vomiting
94. water intoxication
95. weight gain
96. xerostomia

Monitoring Parameters

• AIMS assessment
• CBC
• ophthalmologic exam
• serum prolactin

Contraindications

• abrupt discontinuation
• accidental exposure
• agranulocytosis
• alcoholism
• ambient temperature increase
• angina
• anticholinergic medications
• bone marrow suppression
• bradycardia
• breast cancer
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• chemotherapy
• children
• closed-angle glaucoma
• CNS depression
• coadministration with other CNS depressants
• coma
• coronary artery disease
• dehydration
• dementia
• dental work
• diabetes mellitus
• driving or operating machinery
• dysphagia
• encephalopathy
• ethanol ingestion
• females
• fever
• geriatric
• GI obstruction
• head trauma
• heart failure
• hematological disease
• hepatic disease
• hyperprolactinemia
• hypertension
• hyperthermia
• hypokalemia
• hypomagnesemia
• hypotension
• hypothermia
• hypovolemia
• ileus
• infection
• infertility
• intracranial mass
• intravenous administration
• jaundice
• labor
• leukopenia
• long QT syndrome
• malnutrition
• myocardial infarction
• neonates
• neurological disease
• neutropenia
• obstetric delivery
• ocular disease
• orthostatic hypotension
• Parkinson’s disease
• phenothiazine hypersensitivity
• pregnancy
• pregnancy testing
• prostatic hypertrophy
• pulmonary disease
• QT prolongation
• radiographic contrast administration
• renal failure
• Reye’s syndrome
• seizure disorder
• seizures
• strenuous exercise
• stroke
• suicidal ideation
• sulfite hypersensitivity
• sunlight (UV) exposure
• surgery
• tardive dyskinesia
• thyroid disease
• tobacco smoking
• urinary retention
• vomiting

Interactions

• Abarelix
• Acarbose
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acetohexamide
• Alfentanil
• Alfuzosin
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-glucosidase Inhibitors
• Alprazolam
• Amantadine
• Amifampridine
• Amikacin
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminoglycosides
• Aminolevulinic Acid
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Anagrelide
• Anticholinergics
• Anxiolytics; Sedatives; and Hypnotics
• Apomorphine
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• Aripiprazole
• Arsenic Trioxide
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Azithromycin
• Baclofen
• Barbiturates
• Bedaquiline
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benztropine
• Bepridil
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• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
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• Brexpiprazole
• Brimonidine; Timolol
• Bromocriptine
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• Brompheniramine; Carbetapentane; Phenylephrine
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• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Buprenorphine
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• Bupropion
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• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
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• Cenobamate
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• Charcoal
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• Chloral Hydrate
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroquine
• Chlorothiazide
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorpropamide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clemastine
• Clindamycin; Tretinoin
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• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
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• Dexmethylphenidate
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• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Dicyclomine
• Diethylpropion
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dimenhydrinate
• Dipeptidyl Peptidase-4 Inhibitors
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• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
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• Donepezil
• Donepezil; Memantine
• Dopamine
• Dorzolamide; Timolol
• Doxepin
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Duloxetine
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Eliglustat
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril; Hydrochlorothiazide, HCTZ
• Encorafenib
• Enflurane
• Entrectinib
• Ephedrine
• Epinephrine
• Eprosartan; Hydrochlorothiazide, HCTZ
• Eribulin
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esketamine
• Estazolam
• Eszopiclone
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Ethosuximide
• Ethotoin
• Etomidate
• Ezogabine
• Felbamate
• Fentanyl
• Fingolimod
• Flavoxate
• Flecainide
• Flibanserin
• Fluconazole
• Flucytosine
• Fluocinolone; Hydroquinone; Tretinoin
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluvoxamine
• food
• Foscarnet
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Fospropofol
• Gabapentin
• Ganirelix
• Gemifloxacin
• Gemtuzumab Ozogamicin
• Gentamicin
• Gilteritinib
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• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Goserelin
• Granisetron
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guanidine
• Halobetasol; Tazarotene
• Halofantrine
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Histrelin
• Homatropine; Hydrocodone
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxychloroquine
• Hydroxyzine
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Ibutilide
• Iloperidone
• Imipramine
• Incretin Mimetics
• Indacaterol; Glycopyrrolate
• Indapamide
• Inotuzumab Ozogamicin
• Insulins
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Ipecac
• Isocarboxazid
• Isoflurane
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isosulfan Blue
• Itraconazole
• Ivosidenib
• Kanamycin
• Ketoconazole
• Lamotrigine
• Lanthanum Carbonate
• Lapatinib
• Lasmiditan
• Lefamulin
• Lemborexant
• Lenvatinib
• Leuprolide
• Leuprolide; Norethindrone
• Levetiracetam
• Levodopa
• Levofloxacin
• Levomethadyl
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Lithium
• Lofexidine
• Lomefloxacin
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Lorazepam
• Loxapine
• Lumateperone
• Lurasidone
• Macimorelin
• Magnesium Salts
• Maprotiline
• Meclizine
• Mefloquine
• Meglitinides
• Melatonin
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Mequinol; Tretinoin
• Mestranol; Norethindrone
• Metaxalone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methocarbamol
• Methohexital
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• Methyclothiazide
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• Non-Ionic Contrast Media
• Norepinephrine
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• Olanzapine
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• Ondansetron
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• Oxazepam
• Oxybutynin
• Oxycodone
• Oxymorphone
• Ozanimod
• Paliperidone
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• Pazopanib
• Pemoline
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Phenytoin
• Photosensitizing agents (topical)
• Pilocarpine
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• tobacco
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