Trifarotene

What is Trifarotene

Trifarotene is a retinoic acid receptor (RAR) agonist with specific activity at the gamma subtype of RAR.

The drug is approved for the topical treatment of acne vulgaris in patients 9 years of age and older.

Patients treated with trifarotene may experience local cutaneous adverse reactions, which are typically most severe within the first 4 weeks of treatment.

To reduce the severity of these adverse events, instruct patients to use moisturizers as frequently as needed and to minimize unprotected exposure to ultraviolet rays (i.e., sunlight and sunlamps).

Brand Name

AKLIEF

Indications

  • acne vulgaris

Side Effects

  1. acne vulgaris
  2. edema
  3. erythema
  4. photosensitivity
  5. pruritus
  6. rash
  7. skin discoloration
  8. skin erosion
  9. skin irritation
  10. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • eczema
  • infants
  • neonates
  • ocular exposure
  • pregnancy
  • skin abrasion
  • sunburn
  • sunlight (UV) exposure
  • vaginal administration

Interactions

  • Adapalene; Benzoyl Peroxide
  • Aminolevulinic Acid
  • Benzoyl Peroxide
  • Benzoyl Peroxide; Clindamycin
  • Benzoyl Peroxide; Erythromycin
  • Benzoyl Peroxide; Sulfur
  • Methoxsalen
  • Photosensitizing agents (topical)
  • Porfimer
  • Salicylic Acid
  • Sodium Thiosulfate; Salicylic Acid
  • Verteporfin
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