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What is Trastuzumab and Hyaluronidase combination medicine
Trastuzumab and hyaluronidase oysk is a combination of trastuzumab, a HER2/neu receptor antagonist, and hyaluronidase, an endoglycosidase indicated for the treatment of HER2-overexpressing breast cancer in adults.
Use should be limited to patients with documented overexpression of the HER2 protein, using FDA-approved tests specific for breast cancer; gene amplification and HER2 protein overexpression are not as well correlated in gastric cancer as they are in breast cancer.
Treatment with trastuzumab and hyaluronidase oysk can cause heart failure, with the highest incidence in patients receiving concomitant therapy with anthracyclines; monitor left ventricular function in all patients.
Brand Name
HERCEPTIN HYLECTA
Indications
- breast cancer
For the treatment of HER2-positive breast cancer
Side Effects
- abdominal pain
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- alopecia
- alopecia
- amenorrhea
- anemia
- anemia
- anorexia
- anorexia
- antibody formation
- arrhythmia exacerbation
- arthralgia
- arthralgia
- back pain
- back pain
- bleeding
- bone pain
- bone pain
- constipation
- constipation
- cough
- cough
- diarrhea
- diarrhea
- dizziness
- dizziness
- dysgeusia
- dyspepsia
- dyspnea
- dyspnea
- edema
- edema
- elevated hepatic enzymes
- epistaxis
- erythema
- erythema
- fatigue
- fatigue
- fever
- fever
- flushing
- flushing
- glomerulonephritis
- headache
- headache
- heart failure
- hematoma
- hot flashes
- hypertension
- hypertension
- hypoxia
- infection
- infection
- injection site reaction
- injection site reaction
- insomnia
- insomnia
- leukopenia
- leukopenia
- myalgia
- myalgia
- nasal irritation
- nausea
- nausea
- neutropenia
- neutropenia
- oligomenorrhea
- paresthesias
- paresthesias
- peripheral edema
- peripheral neuropathy
- peripheral neuropathy
- pleural effusion
- pneumonitis
- pruritus
- pulmonary edema
- pulmonary fibrosis
- pulmonary toxicity
- rash
- rash
- serious hypersensitivity reactions or anaphylaxis
- sinus tachycardia
- skin discoloration
- teratogenesis
- thrombocytopenia
- tumor lysis syndrome (TLS)
- vomiting
- vomiting
Monitoring Parameters
- echocardiogram
- multi-gated radionuclide angiography (MUGA)
- pregnancy testing
Contraindications
- asthma
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- chemotherapy
- chronic obstructive pulmonary disease (COPD)
- contraception requirements
- ensure correct formulation selection
- geriatric
- heart failure
- hypertension
- neutropenia
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary fibrosis
- pulmonary toxicity
- reproductive risk
- serious hypersensitivity reactions or anaphylaxis
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Amide local anesthetics
- Aminosalicylate sodium, Aminosalicylic acid
- Anthracyclines
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Chloroprocaine
- Choline Salicylate; Magnesium Salicylate
- Cocaine
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Corticotropin, ACTH
- Cortisone
- Daunorubicin
- Dienogest; Estradiol valerate
- Diethylstilbestrol, DES
- Doxorubicin
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Epirubicin
- Ester local anesthetics
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Idarubicin
- Levobupivacaine
- Lidocaine
- Lidocaine; Prilocaine
- Magnesium Salicylate
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Palifermin
- Penicillamine
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Ropivacaine
- Salicylates
- Salsalate
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Tetracaine
- Tuberculin Purified Protein Derivative, PPD
