What is Torsemide
Torsemide is an oral and IV loop diuretic, the most active of a new series of anilinopyridine sulfonylurea derivatives.
On a weight to weight basis torsemide is twice as potent as furosemide, and provides a longer duration of action at lower urinary concentrations.
This allows for a 24-hour dosage interval and avoids the paradoxical antidiuresis seen with furosemide. Torsemide doses of 10—20 mg are roughly equivalent to 40 mg furosemide and 1 mg bumetanide.
Limited data suggest torsemide exhibits less pronounced effects on the excretion of calcium, magnesium, and potassium than furosemide however, at higher doses, these distinctions may be insignificant.
Torsemide is effective in the treatment of mild to moderate essential hypertension, and in the reduction of edema associated with congestive heart failure, renal disease and hepatic cirrhosis. Torsemide received approval from the FDA on August 23, 1993.
Brand Name
Demadex
Indications
- ascites
- edema
- hypertension
Side Effects
- angina
- angioedema
- anxiety
- arthralgia
- asthenia
- atrial fibrillation
- azotemia
- constipation
- cough
- diarrhea
- dizziness
- dyspepsia
- edema
- GI bleeding
- gout
- headache
- hearing loss
- hypercholesterolemia
- hyperglycemia
- hypertriglyceridemia
- hyperuricemia
- hypokalemia
- hypovolemia
- insomnia
- leukopenia
- myalgia
- nausea
- oliguria
- orthostatic hypotension
- pancreatitis
- pharyngitis
- polyuria
- rash
- rhinitis
- Stevens-Johnson syndrome
- syncope
- thrombocytopenia
- thrombosis
- tinnitus
- toxic epidermal necrolysis
- ventricular tachycardia
- vomiting
- xerostomia
Monitoring Parameters
- audiometry
- blood glucose
- serum creatinine/BUN
- serum electrolytes
- weight
Contraindications
- acute myocardial infarction
- anuria
- breast-feeding
- children
- diabetes mellitus
- electrolyte imbalance
- geriatric
- gout
- hearing impairment
- hepatic disease
- hyperglycemia
- hyperuricemia
- hypochloremia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypovolemia
- pregnancy
- renal disease
- renal failure
- renal impairment
- sulfonamide hypersensitivity
- sulfonylurea hypersensitivity
- sympathectomy
- syncope
- thiazide diuretic hypersensitivity
- ventricular arrhythmias
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