What is Tirofiban
Tirofiban is a synthetic non-peptide platelet glycoprotein IIb/IIIa inhibitor approved for rate reduction of thrombotic cardiovascular events in patients with non-ST elevation acute coronary syndromes.
Inhibition of the platelet glycoprotein IIb/IIIa receptor prevents platelet aggregation.
Tirofiban has a low molecular weight and little, if any, immunogenicity.
When administered at the recommended dosage, > 90% inhibition of platelet aggregation is attained within 10 minutes, and platelet aggregation reverses within 4—8 hours of drug discontinuation.
Tirofiban was FDA-approved in May 1998.
Brand Name
Aggrastat
Indications
- acute myocardial infarction, NSTEMI
- acute myocardial infarction, STEMI
- coronary artery disease
- unstable angina
To reduce the rate of thrombotic cardiovascular events (combined endpoint of death, myocardial infarction, or refractory ischemia/repeat cardiac procedure) in patients with non-ST elevation acute coronary syndromes including acute myocardial infarction, NSTEMI and unstable angina
Side Effects
- anaphylactoid reactions
- bleeding
- bradycardia
- chills
- dizziness
- edema
- fever
- GI bleeding
- headache
- hematemesis
- hematoma
- hematuria
- hemoptysis
- hyperhidrosis
- hypotension
- intracranial bleeding
- nausea
- pelvic pain
- platelet dysfunction
- rash
- retroperitoneal bleeding
- thrombocytopenia
- urticaria
- vomiting
Monitoring Parameters
- activated partial thromboplastin time (APTT)
- clotting time
- hemoglobin/hematocrit
- platelet count
- serum creatinine/BUN
- thrombin time
Contraindications
- aneurysm
- anticoagulant therapy
- aortic dissection
- arteriovenous malformation
- bleeding
- breast-feeding
- coagulopathy
- dialysis
- epidural anesthesia
- geriatric
- hypertension
- intracranial bleeding
- intracranial mass
- intramuscular injections
- lumbar puncture
- pericarditis
- pregnancy
- renal disease
- renal failure
- renal impairment
- spinal anesthesia
- stroke
- surgery
- thrombocytopenia
- thrombolytic therapy
- trauma
- venipuncture
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Ado-Trastuzumab emtansine
- ADP receptor antagonists
- Altretamine
- Aminolevulinic Acid
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Antimetabolites
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Argatroban
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Betrixaban
- Bexarotene
- Bivalirudin
- Chlorambucil
- Cilostazol
- Cladribine
- Clofarabine
- Collagenase
- Dabigatran
- Dalteparin
- Danaparoid
- Danazol
- Defibrotide
- Denileukin Diftitox
- Desirudin
- Desvenlafaxine
- Dipyridamole
- Drotrecogin Alfa
- Duloxetine
- Edoxaban
- Enoxaparin
- Estramustine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fludarabine
- Folate analogs
- Fondaparinux
- Garlic, Allium sativum
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Green Tea
- Heparin
- Ibritumomab Tiuxetan
- Ibrutinib
- Icosapent ethyl
- Iloprost
- Imatinib
- Inotersen
- Intravenous Lipid Emulsions
- Lepirudin
- Levomilnacipran
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Lomustine, CCNU
- Mercaptopurine, 6-MP
- Methoxsalen
- Methylsulfonylmethane, MSM
- Milnacipran
- Mycophenolate
- Nelarabine
- Nonsteroidal antiinflammatory drugs
- Obinutuzumab
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Pegaspargase
- Pentosan
- Pentostatin
- Pentoxifylline
- Phentermine; Topiramate
- Photosensitizing agents (topical)
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Purine analogs
- Rivaroxaban
- Selective serotonin reuptake inhibitors
- Selumetinib
- Sodium Hyaluronate, Hyaluronic Acid
- Sulfinpyrazone
- Thioguanine, 6-TG
- Thrombolytic Agents
- Tinzaparin
- Tipranavir
- Topiramate
- Treprostinil
- Tretinoin, ATRA
- Venlafaxine
- Verteporfin
- Vilazodone
- Vorapaxar
- Vortioxetine
- Warfarin
