Tetracycline

What is Tetracycline

Tetracycline is semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens.

It is classified as a short-acting tetracycline, although this classification scheme is somewhat artificial since tetracycline can be dosed at longer intervals than usually occurs in clinical practice.

It has a wide spectrum of activity against many gram-negative and gram-positive organisms, but is inactive against viruses and fungi.

The most common uses of tetracycline are to treat ChlamydiaMycoplasma pneumoniae, and rickettsial infections.

Tetracycline is also effective in combination with bismuth salts, metronidazole, and appropriate acid-suppressive therapy to treat Helicobacter pylori(H. pylori) gastrointestinal infection.

Tetracycline is available in oral and topical preparations, including an ophthalmic ointment.

The drug first received FDA approval in 1953.

Tetracycline periodontal fibers were approved March 1994 for adjunct treatment of periodontitis.

Two products that contain tetracycline, Helidac(R) (bismuth subsalicylate, metronidazole, and tetracycline) and Pylera(TM) (bismuth subcitrate potassium, metronidazole, and tetracycline) are approved to eradicate H. pylori infection associated with duodenal ulcer disease (see separate monographs).

As of March 2007, tetracycline oral suspension is no longer commercially available in the U.S.

Brand Name

  • Emtet-500
  • Panmycin
  • Sumycin

Indications

  • Acinetobacter sp.
  • acne rosacea
  • acne vulgaris
  • Actinomyces sp.
  • actinomycosis
  • amebiasis
  • anthrax
  • Bacillus anthracis
  • Bacteroides sp.
  • Balantidium coli
  • Bartonella bacilliformis
  • bartonellosis
  • Borrelia recurrentis
  • Brucella sp.
  • brucellosis
  • Campylobacter fetus
  • cervicitis
  • chancroid
  • chlamydia infection
  • Chlamydia trachomatis
  • chlamydial conjunctivitis
  • Chlamydophila psittaci
  • cholera
  • Clostridium sp.
  • dental infection
  • dentoalveolar infection
  • endodontic infection
  • Entamoeba histolytica
  • Entamoeba sp.
  • Escherichia coli
  • Francisella tularensis
  • Fusobacterium fusiforme
  • gonorrhea
  • granuloma inguinale
  • Haemophilus ducreyi
  • Haemophilus influenzae (beta-lactamase negative)
  • Haemophilus influenzae (beta-lactamase positive)
  • Helicobacter pylori (H. pylori) eradication
  • Klebsiella aerogenes
  • Klebsiella granulomatis
  • Klebsiella sp.
  • Listeria monocytogenes
  • listeriosis
  • lower respiratory tract infections
  • lymphogranuloma venereum
  • malaria
  • murine typhus
  • Mycoplasma pneumoniae
  • necrotizing ulcerative gingivitis
  • Neisseria gonorrhoeae
  • periodontitis
  • plague
  • plague prophylaxis
  • proctitis
  • Propionibacterium acnes
  • psittacosis
  • Q fever
  • relapsing fever
  • Rickettsia sp.
  • Rickettsial pox
  • Rocky Mountain spotted fever
  • Shigella sp.
  • shigellosis
  • skin and skin structure infections
  • Staphylococcus aureus (MRSA)
  • Staphylococcus aureus (MSSA)
  • Streptococcus pneumoniae
  • Streptococcus pyogenes (group A beta-hemolytic streptococci)
  • syphilis
  • trachoma
  • Treponema pallidum
  • Treponema pertenue
  • tularemia
  • upper respiratory tract infections
  • urethritis
  • urinary tract infection (UTI)
  • Vibrio cholerae
  • yaws
  • Yersinia pestis

Side Effects

  1. anaphylactoid reactions
  2. angioedema
  3. anorexia
  4. arthralgia
  5. azotemia
  6. blurred vision
  7. candidiasis
  8. diarrhea
  9. diplopia
  10. dysphagia
  11. enamel hypoplasia
  12. enterocolitis
  13. eosinophilia
  14. erythema
  15. esophageal ulceration
  16. esophagitis
  17. exfoliative dermatitis
  18. fever
  19. glossitis
  20. headache
  21. hemolytic anemia
  22. hepatic failure
  23. increased intracranial pressure
  24. Jarisch-Herxheimer reaction
  25. lupus-like symptoms
  26. maculopapular rash
  27. nail discoloration
  28. nausea
  29. neutropenia
  30. papilledema
  31. pericarditis
  32. photosensitivity
  33. pseudotumor cerebri
  34. purpura
  35. rash
  36. serum sickness
  37. superinfection
  38. teratogenesis
  39. thrombocytopenia
  40. thrombotic thrombocytopenic purpura (TTP)
  41. tongue discoloration
  42. tooth discoloration
  43. urticaria
  44. vomiting

Monitoring Parameters

  • LFTs

Contraindications

  • breast-feeding
  • children
  • colitis
  • corticosteroid therapy
  • diarrhea
  • geriatric
  • GI disease
  • hepatic disease
  • infants
  • inflammatory bowel disease
  • laboratory test interference
  • neonates
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal failure
  • renal impairment
  • sexually transmitted disease
  • sulfite hypersensitivity
  • sunlight (UV) exposure
  • surgery
  • tartrazine dye hypersensitivity
  • tetracyclines hypersensitivity
  • ulcerative colitis

Interactions

  • Acitretin
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amoxicillin
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amoxicillin; Clavulanic Acid
  • Ampicillin
  • Ampicillin; Sulbactam
  • Antacids
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Atovaquone
  • Atovaquone; Proguanil
  • Bexarotene
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Carbenicillin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Cholestyramine
  • Chromium
  • Colesevelam
  • Colestipol
  • Dicloxacillin
  • Didanosine, ddI
  • Dienogest; Estradiol valerate
  • Digoxin
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • food
  • Halobetasol; Tazarotene
  • Heparin
  • Hetastarch; Dextrose; Electrolytes
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Insoluble Prussian Blue
  • Iron
  • Iron Salts
  • Iron Sucrose, Sucroferric Oxyhydroxide
  • Isotretinoin
  • Lanthanum Carbonate
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Lithium
  • Lomitapide
  • Magnesium
  • Magnesium Citrate
  • Magnesium Hydroxide
  • Magnesium Salts
  • Mestranol; Norethindrone
  • Methotrexate
  • Methoxsalen
  • Metoclopramide
  • Mipomersen
  • Molindone
  • Nafcillin
  • Neuromuscular blockers
  • Norethindrone
  • Norgestrel
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oral Contraceptives
  • Oxacillin
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Penicillin V
  • Penicillins
  • Photosensitizing agents (topical)
  • Piperacillin
  • Piperacillin; Tazobactam
  • Polycarbophil
  • Polysaccharide-Iron Complex
  • Porfimer
  • Pyridostigmine
  • Quinapril
  • Quinine
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Bicarbonate
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • St. John’s Wort, Hypericum perforatum
  • Sucralfate
  • Sulfonylureas
  • Tazarotene
  • Ticarcillin
  • Ticarcillin; Clavulanic Acid
  • Tretinoin, ATRA
  • Verteporfin
  • Warfarin
  • Zinc
  • Zinc Salts
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top