What is Tetrahydrozoline

Tetrahydrozoline is an intranasal and ophthalmic topical vasoconstrictor. It is administered intranasally to treat nasal congestion associated with acute or chronic rhinitis, sinusitis, the common cold, and hay fever and other allergies.

The effectiveness of xylometazoline for relieving nasal congestion and its adverse effect profile are similar to other imidazoline derivatives.

Excessive or prolonged nasal use can cause nasal mucosa irritation; nasal use should generally not exceed 3 consecutive days since some degree of rebound congestion usually results.

Tetrahydrozoline is administered ophthalmically to relieve redness of the eye due to minor ocular irritants. This drug was approved by the FDA in 1954.



  • nasal congestion
  • xerophthalmia

For the relief of redness of the eye due to minor irritations or relief of burning and irritation due to xerophthalmia or discomfort due to minor irritations or to exposure to wind or sun

Side Effects

  1. blurred vision
  2. bradycardia
  3. coma
  4. drowsiness
  5. headache
  6. hypertension
  7. hypotension
  8. hypothermia
  9. insomnia
  10. lethargy
  11. mydriasis
  12. nasal congestion
  13. nasal dryness
  14. nasal irritation
  15. nausea
  16. ocular irritation
  17. ocular pain
  18. palpitations
  19. respiratory depression
  20. rhinitis
  21. sinus tachycardia
  22. sneezing
  23. tremor
  24. visual impairment
  25. vomiting
  26. weakness

Monitoring Parameters

  • laboratory monitoring not necessary


  • breast-feeding
  • children
  • closed-angle glaucoma
  • contact lenses
  • coronary artery disease
  • diabetes mellitus
  • hypertension
  • hyperthyroidism
  • infants
  • MAOI therapy
  • neonates
  • pregnancy


  • Colchicine
  • Colchicine; Probenecid
  • Linezolid
  • Monoamine oxidase inhibitors
  • Nafarelin
  • Nicotine
  • Rasagiline

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