Tetrabenazine

What is Tetrabenazine

Tetrabenazine, a synthetic benzoquinolizine derivative, is a monoamine depleter and dopamine receptor blocker that improves the symptoms associated with Huntington’s disease (HD), and is considered a first line treatment for HD associated chorea by the American Academy of Neurology.

Tetrabenazine appears to have the best effect in HD but has shown improvement in other hyperkinetic movements disorders, such as tardive dyskinesia (TD), dystonia, Tourette’s syndrome, and myoclonus.

Brand Name

Xenazine

Indications

  • Huntington’s Disease (Huntington’s Chorea)

For the treatment of chorea associated with Huntington’s Disease (Huntington’s Chorea)

Side Effects

  1. akathisia
  2. anorexia
  3. anxiety
  4. confusion
  5. depression
  6. diarrhea
  7. dizziness
  8. drowsiness
  9. dysarthria
  10. dysphagia
  11. dyspnea
  12. dystonic reaction
  13. dysuria
  14. ecchymosis
  15. fatigue
  16. headache
  17. hyperhidrosis
  18. hyperkinesis
  19. hyperprolactinemia
  20. hypertonia
  21. infection
  22. insomnia
  23. irritability
  24. nausea
  25. neuroleptic malignant syndrome
  26. orthostatic hypotension
  27. pseudoparkinsonism
  28. QT prolongation
  29. rash
  30. restlessness
  31. suicidal ideation
  32. syncope
  33. tremor
  34. vomiting
  35. weakness

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • alcoholism
  • bradycardia
  • breast cancer
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • CNS depression
  • coma
  • coronary artery disease
  • dehydration
  • depression
  • diabetes mellitus
  • driving or operating machinery
  • dysphagia
  • females
  • fever
  • geriatric
  • heart failure
  • hepatic disease
  • hyperprolactinemia
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypovolemia
  • infertility
  • long QT syndrome
  • malnutrition
  • MAOI therapy
  • myocardial infarction
  • neurological disease
  • orthostatic hypotension
  • Parkinson’s disease
  • pregnancy
  • QT prolongation
  • renal disease
  • renal failure
  • renal impairment
  • suicidal ideation
  • surgery
  • thyroid disease

Interactions

  • Abarelix
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Albuterol
  • Albuterol; Ipratropium
  • Alfentanil
  • Alfuzosin
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Amiodarone
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
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  • Aspirin, ASA; Butalbital; Caffeine; Codeine
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  • Brompheniramine; Hydrocodone; Pseudoephedrine
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  • Captopril; Hydrochlorothiazide, HCTZ
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  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cenobamate
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Cetrorelix
  • Chloroquine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Ciprofloxacin
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  • Clarithromycin
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  • Clonidine
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  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Crizotinib
  • Dacomitinib
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasatinib
  • Degarelix
  • Desvenlafaxine
  • Deutetrabenazine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doxazosin
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  • Dronabinol
  • Dronedarone
  • Droperidol
  • Efavirenz
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  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eliglustat
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  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril, Enalaprilat
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  • Formoterol
  • Formoterol; Mometasone
  • Foscarnet
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gabapentin
  • Ganirelix
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  • Gemtuzumab Ozogamicin
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  • Glasdegib
  • Glycopyrrolate; Formoterol
  • Goserelin
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  • Halogenated Anesthetics
  • Haloperidol
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibuprofen; Oxycodone
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  • Iloprost
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  • Inotuzumab Ozogamicin
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  • Lithium
  • Lofexidine
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  • Loperamide
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  • Lopinavir; Ritonavir
  • Loxapine
  • Lumateperone
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  • Macimorelin
  • Maprotiline
  • Mecamylamine
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  • Metoclopramide
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  • Pentamidine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine; Promethazine
  • Pimavanserin
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  • Verapamil
  • Voriconazole
  • Vorinostat
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