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What is Tetrabenazine
Tetrabenazine, a synthetic benzoquinolizine derivative, is a monoamine depleter and dopamine receptor blocker that improves the symptoms associated with Huntington’s disease (HD), and is considered a first line treatment for HD associated chorea by the American Academy of Neurology.
Tetrabenazine appears to have the best effect in HD but has shown improvement in other hyperkinetic movements disorders, such as tardive dyskinesia (TD), dystonia, Tourette’s syndrome, and myoclonus.
Brand Name
Xenazine
Indications
- Huntington’s Disease (Huntington’s Chorea)
For the treatment of chorea associated with Huntington’s Disease (Huntington’s Chorea)
Side Effects
- akathisia
- anorexia
- anxiety
- confusion
- depression
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dysphagia
- dyspnea
- dystonic reaction
- dysuria
- ecchymosis
- fatigue
- headache
- hyperhidrosis
- hyperkinesis
- hyperprolactinemia
- hypertonia
- infection
- insomnia
- irritability
- nausea
- neuroleptic malignant syndrome
- orthostatic hypotension
- pseudoparkinsonism
- QT prolongation
- rash
- restlessness
- suicidal ideation
- syncope
- tremor
- vomiting
- weakness
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- alcoholism
- bradycardia
- breast cancer
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- CNS depression
- coma
- coronary artery disease
- dehydration
- depression
- diabetes mellitus
- driving or operating machinery
- dysphagia
- females
- fever
- geriatric
- heart failure
- hepatic disease
- hyperprolactinemia
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypovolemia
- infertility
- long QT syndrome
- malnutrition
- MAOI therapy
- myocardial infarction
- neurological disease
- orthostatic hypotension
- Parkinson’s disease
- pregnancy
- QT prolongation
- renal disease
- renal failure
- renal impairment
- suicidal ideation
- surgery
- thyroid disease
Interactions
- Abarelix
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Angiotensin-converting enzyme inhibitors
- Anxiolytics; Sedatives; and Hypnotics
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atomoxetine
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Beta-adrenergic blockers
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brexpiprazole
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Cabergoline
- Cannabidiol
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Cetrorelix
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clevidipine
- Clofazimine
- Clonidine
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crizotinib
- Dacomitinib
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasatinib
- Degarelix
- Desvenlafaxine
- Deutetrabenazine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxazosin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Entacapone
- Entrectinib
- Eplerenone
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Ethanol
- Ezogabine
- Felodipine
- Fentanyl
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Gabapentin
- Ganirelix
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanabenz
- Guanfacine
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Histrelin
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxychloroquine
- Hydroxyzine
- Ibuprofen; Oxycodone
- Ibutilide
- Iloperidone
- Iloprost
- Indacaterol
- Indacaterol; Glycopyrrolate
- Inotuzumab Ozogamicin
- Isocarboxazid
- Isradipine
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levocetirizine
- Levodopa
- Levofloxacin
- Levorphanol
- Lisinopril
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loxapine
- Lumateperone
- Lurasidone
- Macimorelin
- Maprotiline
- Mecamylamine
- Mefloquine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mesoridazine
- Metaproterenol
- Methadone
- Methyldopa
- Metoclopramide
- Metronidazole
- Midostaurin
- Mifepristone
- Mirabegron
- Mirtazapine
- Moexipril
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Nabilone
- Nafarelin
- Nalbuphine
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Norfloxacin
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ondansetron
- Oritavancin
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- Osimertinib
- Oxaliplatin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Panobinostat
- Paroxetine
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2b
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phenoxybenzamine
- Phentolamine
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pirbuterol
- Pitolisant
- Posaconazole
- Potassium-sparing diuretics
- Prazosin
- Pregabalin
- Primaquine
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Propoxyphene
- Quetiapine
- Quinapril
- Quinidine
- Quinine
- Ramipril
- Ranolazine
- Rasagiline
- Remifentanil
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Rolapitant
- Romidepsin
- Safinamide
- Salmeterol
- Saquinavir
- Selegiline
- Selpercatinib
- Sertraline
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- Sparfloxacin
- Sufentanil
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Terazosin
- Terbutaline
- Thiazide diuretics
- Thioridazine
- Thiothixene
- Tiotropium; Olodaterol
- Tipranavir
- Tolcapone
- Tolterodine
- Toremifene
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Tricyclic antidepressants
- Trifluoperazine
- Triptorelin
- Umeclidinium; Vilanterol
- Valbenazine
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Verapamil
- Voriconazole
- Vorinostat
- Ziprasidone
