Ranitidine

What is Ranitidine

Ranitidine is an oral and parenteral histamine type 2-receptor antagonist used in the treatment of various gastrointestinal disorders such as peptic ulcer and gastroesophageal reflux disease (GERD). 

Indications

  • anaphylaxis
  • angioedema
  • aspiration prophylaxis
  • duodenal ulcer
  • dyspepsia
  • esophagitis
  • gastric ulcer
  • gastritis
  • gastroesophageal reflux disease (GERD)
  • multiple endocrine adenoma syndrome
  • NSAID-induced ulcer prophylaxis
  • pyrosis (heartburn)
  • stress gastritis prophylaxis
  • systemic mastocytosis
  • urticaria
  • Zollinger-Ellison syndrome

Side Effects

  1. abdominal pain
  2. agitation
  3. agranulocytosis
  4. alopecia
  5. anaphylactoid reactions
  6. angioedema
  7. aplastic anemia
  8. arthralgia
  9. asthenia
  10. atrophic gastritis
  11. AV block
  12. blurred vision
  13. bradycardia
  14. bronchospasm
  15. confusion
  16. constipation
  17. cough
  18. depression
  19. diarrhea
  20. dizziness
  21. drowsiness
  22. elevated hepatic enzymes
  23. eosinophilia
  24. erythema multiforme
  25. fever
  26. galactorrhea
  27. gynecomastia
  28. hallucinations
  29. headache
  30. hemolytic anemia
  31. hepatitis
  32. impotence (erectile dysfunction)
  33. infection
  34. injection site reaction
  35. insomnia
  36. interstitial nephritis
  37. jaundice
  38. leukopenia
  39. libido decrease
  40. malaise
  41. myalgia
  42. nausea
  43. neutropenia
  44. pancreatitis
  45. pancytopenia
  46. paranoia
  47. pernicious anemia
  48. premature ventricular contractions (PVCs)
  49. pruritus
  50. rash
  51. sinus tachycardia
  52. thrombocytopenia
  53. toxic epidermal necrolysis
  54. vasculitis
  55. vertigo
  56. vitamin B12 deficiency
  57. vomiting

Monitoring Parameters

  • intragastric pH
  • LFTs
  • serum creatinine/BUN
  • stool guaiac

Contraindications

  • bradycardia
  • breast-feeding
  • cardiac disease
  • children
  • gastric cancer
  • geriatric
  • H2-blocker hypersensitivity
  • hepatic disease
  • infants
  • infection
  • neonates
  • porphyria
  • pregnancy
  • premature neonates
  • renal disease
  • renal failure
  • renal impairment
  • tobacco smoking
  • vitamin B12 deficiency

Interactions

  • Acalabrutinib
  • Acetohexamide
  • Adefovir
  • Alendronate
  • Alendronate; Cholecalciferol
  • Alogliptin; Pioglitazone
  • Amphetamine; Dextroamphetamine Salts
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atracurium
  • Bisacodyl
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bosutinib
  • Budesonide
  • Budesonide; Formoterol
  • Calcium Carbonate; Risedronate
  • Cefditoren
  • Cefpodoxime
  • Ceftibuten
  • Cefuroxime
  • Chlorpropamide
  • Cisatracurium
  • Cyclosporine
  • Cysteamine
  • Dacomitinib
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasatinib
  • Delavirdine
  • Dexmethylphenidate
  • Diphenhydramine; Naproxen
  • Dirithromycin
  • Dolutegravir; Rilpivirine
  • Donepezil; Memantine
  • Eliglustat
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Entecavir
  • Erlotinib
  • Esomeprazole; Naproxen
  • Ethanol
  • Flibanserin
  • Fluvastatin
  • Fosamprenavir
  • Gefitinib
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Iron
  • Itraconazole
  • Ketoconazole
  • Lansoprazole; Naproxen
  • Ledipasvir; Sofosbuvir
  • Lemborexant
  • Lomefloxacin
  • Lomitapide
  • Loperamide
  • Loperamide; Simethicone
  • Lumacaftor; Ivacaftor
  • Mefloquine
  • Memantine
  • Mesalamine, 5-ASA
  • Metformin; Pioglitazone
  • Methylphenidate
  • Midazolam
  • Midodrine
  • Mivacurium
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Neratinib
  • Nicardipine
  • Nifedipine
  • Nilotinib
  • Pancuronium
  • Pazopanib
  • Pexidartinib
  • Pioglitazone
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Ponatinib
  • Procainamide
  • Propantheline
  • Ranolazine
  • Rilpivirine
  • Risedronate
  • Risperidone
  • Rocuronium
  • Saquinavir
  • Secretin
  • Selpercatinib
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Sonidegib
  • Sulfonylureas
  • Thalidomide
  • Tolazamide
  • Tolbutamide
  • Triazolam
  • Trospium
  • Vecuronium