What is Teniposide
Teniposide is a cytotoxic drug that is a topoisomerase II inhibitor.
It is indicated in combination with other chemotherapy for induction therapy in patients with refractory acute lymphocytic leukemia.
Severe myelosuppression and hypersensitivity reactions have occurred with teniposide therapy
Brand Name
Vumon
Indications
- acute lymphocytic leukemia (ALL)
- bladder cancer
- neuroblastoma
- non-Hodgkin’s lymphoma (NHL)
- non-small cell lung cancer (NSCLC)
- small cell lung cancer (SCLC)
For the treatment of previously untreated advanced neuroblastoma†, in combination with cisplatin or cisplatin, cyclophosphamide, and doxorubicin
Side Effects
- alopecia
- anemia
- asthenia
- bleeding
- bone marrow suppression
- bronchospasm
- chills
- confusion
- diarrhea
- dyspnea
- fever
- flushing
- headache
- hepatotoxicity
- hypertension
- hypoalbuminemia
- hypotension
- infection
- leukemia
- leukopenia
- nausea
- nephrotoxicity
- neurotoxicity
- neutropenia
- new primary malignancy
- peripheral neuropathy
- phlebitis
- rash
- serious hypersensitivity reactions or anaphylaxis
- sinus tachycardia
- thrombocytopenia
- tissue necrosis
- urticaria
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
- serum creatinine/BUN
Contraindications
- anemia
- bleeding
- bone marrow suppression
- brain tumor
- breast-feeding
- Down’s syndrome
- extravasation
- hepatic disease
- hypoalbuminemia
- infection
- infertility
- male-mediated teratogenicity
- neutropenia
- polyoxyethylated castor oil hypersensitivity
- pregnancy
- renal impairment
- reproductive risk
- requires a specialized care setting
- requires an experienced clinician
- serious hypersensitivity reactions or anaphylaxis
- thrombocytopenia
Interactions
- Amlodipine; Celecoxib
- Apalutamide
- Aprepitant, Fosaprepitant
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Boceprevir
- Carbamazepine
- Carvedilol
- Celecoxib
- Cobicistat
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Cyclizine
- Cyclosporine
- Daclatasvir
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dextromethorphan; Promethazine
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Dimenhydrinate
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dronabinol
- Dronedarone
- Droperidol
- Elbasvir; Grazoprevir
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Esomeprazole; Naproxen
- Etodolac
- Etravirine
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- Fosamprenavir
- Fosphenytoin
- Glecaprevir; Pibrentasvir
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Indomethacin
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ixabepilone
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Ledipasvir; Sofosbuvir
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Meclizine
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Meperidine; Promethazine
- Methotrexate
- Mitotane
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nilotinib
- Nonsteroidal antiinflammatory drugs
- Ombitasvir; Paritaprevir; Ritonavir
- Oritavancin
- Oxaprozin
- Palifermin
- Pazopanib
- Penicillamine
- Phenobarbital
- Phenylephrine; Promethazine
- Phenytoin
- Piroxicam
- Posaconazole
- Primidone
- Prochlorperazine
- Promethazine
- Rifampin
- Ritonavir
- Rofecoxib
- Sapropterin
- Simeprevir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- St. John’s Wort, Hypericum perforatum
- Sulindac
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Thiethylperazine
- Tolbutamide
- Tolmetin
- Trimethobenzamide
- Tuberculin Purified Protein Derivative, PPD
- Valdecoxib
- Vemurafenib
- Vincristine
- Vincristine Liposomal
- Zonisamide
