What's on this Page
What is Telbivudine
Telbivudine is a synthetic thymidine nucleoside analogue with activity against hepatitis B virus (HBV).
Telbivudine is not a cure for HBV, but the drug may lower viral load and prevent infection of new hepatocytes.
When compared to lamivudine 100 mg/day for 1 year in patients with HBeAg-positive chronic HBV, patients receiving telbivudine 400 or 600 mg/day had a greater virologic and biochemical response; patients experienced a greater mean reduction in HBV DNA levels, (6.01 vs. 4.57 log10 copies/ml reduction for telbivudine vs. lamivudine, respectively, p < 0.05), greater HBV DNA clearance (61% vs. 32% for telbivudine vs. lamivudine, respectively p < 0.05), and a higher number achieving normalization of ALT concentrations (86% vs 63% for telbivudine vs. lamivudine, respectively, p < 0.05). In this same trial, a combination of telbivudine and lamivudine was also evaluated, but combination therapy conferred no additional benefit over telbivudine monotherapy.
Brand Name
Tyzeka
Indications
- hepatitis B infection
- hepatitis B virus
Side Effects
- abdominal pain
- antimicrobial resistance
- arthralgia
- back pain
- chest pain (unspecified)
- cough
- diarrhea
- dizziness
- dyspepsia
- elevated hepatic enzymes
- fatigue
- fever
- flank pain
- headache
- hepatitis B exacerbation
- hepatomegaly
- hepatotoxicity
- hyperamylasemia
- hyperbilirubinemia
- hypoesthesia
- insomnia
- lactic acidosis
- muscle cramps
- musculoskeletal pain
- myalgia
- myopathy
- nausea
- neutropenia
- paresthesias
- peripheral neuropathy
- pruritus
- rash
- rhabdomyolysis
- steatosis
- thrombocytopenia
- vomiting
- weakness
Monitoring Parameters
- hepatitis B serology
- LFTs
Contraindications
- antimicrobial resistance
- Black patients
- breast-feeding
- children
- dialysis
- geriatric
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatotoxicity or lactic acidosis
- Hispanic patients
- human immunodeficiency virus (HIV) infection
- human immunodeficiency virus (HIV) infection resistance
- infants
- liver transplant
- myopathy
- neonates
- pancreatitis
- pregnancy
- renal disease
- renal failure
- renal impairment
- rhabdomyolysis
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acyclovir
- Adefovir
- Amikacin
- Amlodipine; Celecoxib
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Angiotensin-converting enzyme inhibitors
- Celecoxib
- Chloroquine
- Cidofovir
- Cisplatin
- Corticosteroids
- Cyclosporine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Echinacea
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Fibric acid derivatives
- Fluconazole
- Flurbiprofen
- food
- Foscarnet
- Ganciclovir
- HMG-CoA reductase inhibitors
- Hydrocodone; Ibuprofen
- Hydroxychloroquine
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Interferon Beta-1a
- Interferon Beta-1b
- Interferon Gamma-1b
- Interferons
- Itraconazole
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lamivudine, 3TC; Zidovudine, ZDV
- Lansoprazole; Naproxen
- Lovastatin; Niacin
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Niacin, Niacinamide
- Niacin; Simvastatin
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Orlistat
- Oxaprozin
- Pamidronate
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Peginterferon beta-1a
- Penicillamine
- Piroxicam
- Ribavirin
- Rofecoxib
- Sulindac
- Tacrolimus
- Tolmetin
- Valacyclovir
- Valdecoxib
- Valganciclovir
- Vancomycin
- Voriconazole
- Zidovudine, ZDV
- Zoledronic Acid