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What is Telithromycin
Telithromycin (HMR 3647) is a broad-spectrum antibiotic and the first in a family called ‘ketolides’.
Chemically, ketolides resemble macrolides, however, telithromycin exhibits greater antibacterial killing than macrolides. Telithromycin has been studied in multiple types of respiratory tract infections and its spectrum of activity is good against respiratory pathogens including erythromycin- and penicillin-resistant pneumococci.
Telithromycin also has activity against intracellular and atypical bacteria. Telithromycin once daily is as effective as clarithromycin, trovafloxacin, and high dose amoxicillin for some infections. Nearly 2500 patients have received telithromycin in clinical trials.
Brand Name
Ketek
Indications
- Chlamydophila pneumoniae
- community-acquired pneumonia
- Coxiella burnetii
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Legionella pneumophila
- Moraxella catarrhalis
- Mycoplasma pneumoniae
- Staphylococcus aureus (MSSA)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp.
Side Effects
- abdominal pain
- anaphylactoid reactions
- angioedema
- anorexia
- anosmia
- anxiety
- arthralgia
- blurred vision
- bradycardia
- candidiasis
- confusion
- constipation
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysgeusia
- dysosmia
- dyspepsia
- dyspnea
- eczema vaccinatum
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fatigue
- flatulence
- flushing
- gastritis
- glossitis
- hallucinations
- hearing loss
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperbilirubinemia
- hyperhidrosis
- hypotension
- insomnia
- jaundice
- muscle cramps
- myalgia
- myasthenia gravis
- nausea
- palpitations
- pancreatitis
- paresthesias
- pruritus
- pseudomembranous colitis
- QT prolongation
- rash
- stomatitis
- syncope
- thrombocytosis
- torsade de pointes
- tremor
- urticaria
- vaginitis
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- alcoholism
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- colitis
- coronary artery disease
- diabetes mellitus
- diarrhea
- driving or operating machinery
- females
- geriatric
- GI disease
- heart failure
- hepatic disease
- hepatitis
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- infants
- inflammatory bowel disease
- jaundice
- long QT syndrome
- macrolide hypersensitivity
- malnutrition
- myasthenia gravis
- myocardial infarction
- neonates
- pregnancy
- pseudomembranous colitis
- QT prolongation
- renal failure
- renal impairment
- thyroid disease
- viral infection
Interactions
- Abarelix
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Ado-Trastuzumab emtansine
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alosetron
- Alprazolam
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anagrelide
- Apalutamide
- Apixaban
- Apomorphine
- Aprepitant, Fosaprepitant
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Axitinib
- Azelastine; Fluticasone
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Bepridil
- Betamethasone
- Betrixaban
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bortezomib
- Bosentan
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
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- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Cabazitaxel
- Cabozantinib
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- Calcifediol
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- Capmatinib
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- Cevimeline
- Chloramphenicol
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
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- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
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- Codeine; Promethazine
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- Drospirenone; Ethinyl Estradiol; Levomefolate
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- Edoxaban
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- Elagolix
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- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eluxadoline
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- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Enfortumab vedotin
- Entrectinib
- Enzalutamide
- Eplerenone
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- Ergoloid Mesylates
- Ergonovine
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- Ergotamine
- Eribulin
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- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Estradiol Cypionate; Medroxyprogesterone
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- Estradiol; Norgestimate
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etonogestrel
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Ezogabine
- Fedratinib
- Felodipine
- Fentanyl
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- Fluvoxamine
- food
- Formoterol
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosphenytoin
- Fostamatinib
- Galantamine
- Gefitinib
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Histrelin
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyzine
- Ibrutinib
- Ibuprofen; Oxycodone
- Ibutilide
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Inotuzumab Ozogamicin
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Istradefylline
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Lacosamide
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole
- Lansoprazole; Naproxen
- Lapatinib
- Larotrectinib
- Lefamulin
- Lemborexant
- Lenvatinib
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levofloxacin
- Levomethadyl
- Levomilnacipran
- Levonorgestrel
- Lidocaine
- Lidocaine; Prilocaine
- Lithium
- Lofexidine
- Lomitapide
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macimorelin
- Macitentan
- Maprotiline
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Meperidine; Promethazine
- Mestranol; Norethindrone
- Metaproterenol
- Metformin; Repaglinide
- Metformin; Saxagliptin
- Methadone
- Methylergonovine
- Methylprednisolone
- Methysergide
- Metoprolol
- Metronidazole
- Midazolam
- Midostaurin
- Mifepristone
- Mirtazapine
- Mitomycin
- Mitotane
- Modafinil
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- Moxifloxacin
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nintedanib
- Nisoldipine
- Norethindrone
- Norfloxacin
- Norgestrel
- Octreotide
- Ofloxacin
- Olanzapine
- Olaparib
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
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- Ondansetron
- Oral Contraceptives
- Oritavancin
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- Osimertinib
- Ospemifene
- Oxaliplatin
- Oxcarbazepine
- Oxybutynin
- Oxycodone
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- Palbociclib
- Paliperidone
- Panobinostat
- Paricalcitol
- Pasireotide
- Pazopanib
- Pemigatinib
- Pentamidine
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pirbuterol
- Pitavastatin
- Pitolisant
- Polatuzumab Vedotin
- Ponatinib
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- Prednisolone
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- Prochlorperazine
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- Riluzole
- Rimegepant
- Riociguat
- Ripretinib
- Risperidone
- Ritonavir
- Rivaroxaban
- Romidepsin
- Rosuvastatin
- Rufinamide
- Ruxolitinib
- Sacubitril; Valsartan
- Salmeterol
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
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- Sertraline
- Short-acting beta-agonists
- Sibutramine
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
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- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sofosbuvir; Velpatasvir
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