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What is Telavancin
Telavancin (Vibativ) is the first FDA-approved agent in the lipoglycopeptide class of antibiotics.
It is a semi-synthetic derivative of vancomycin with rapid concentration-dependent bactericidal action against selected gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA).
It is administered once daily, a potential advantage over some other antimicrobial agents with a similar spectrum of activity; however, it carries boxed warnings for use during pregnancy and in patients with preexisting renal insufficiency, as it has been associated with abnormal fetal development and worsening renal function/increased mortality.
Telavancin received FDA approval for treatment of complicated skin and skin structure infections caused by susceptible gram-positive bacteria in September 2009.
In June 2013, the FDA expanded the drugs approved indications to include use as a last line agent in the treatment of nosocomial pneumonia (hospital-acquired and ventilator-associated) caused by Staphylococcal aureus.
Brand Name
Vibativ
Indications
- bacteremia
- Enterococcus faecalis
- Enterococcus faecium
- nosocomial pneumonia
- skin and skin structure infections
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Staphylococcus haemolyticus
- Streptococcus agalactiae (group B streptococci)
- Streptococcus anginosus
- Streptococcus constellatus
- Streptococcus dysgalactiae
- Streptococcus intermedius
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
Side Effects
- abdominal pain
- anaphylactoid reactions
- chills
- diarrhea
- dizziness
- erythema
- flushing
- headache
- infertility
- infusion-related reactions
- metallic taste
- nausea
- nephrotoxicity
- pruritus
- pseudomembranous colitis
- QT prolongation
- rash
- red man syndrome
- renal failure (unspecified)
- superinfection
- urticaria
- vomiting
Monitoring Parameters
- CBC with differential
- pregnancy testing
- serum creatinine/BUN
Contraindications
- alcoholism
- anticoagulant therapy
- antimicrobial resistance
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- contraception requirements
- coronary artery disease
- diabetes mellitus
- diarrhea
- females
- geriatric
- GI disease
- heart failure
- hepatic disease
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- infertility
- inflammatory bowel disease
- infusion-related reactions
- intramuscular administration
- long QT syndrome
- malnutrition
- mortality
- myocardial infarction
- nephrotoxicity
- pregnancy
- pregnancy testing
- pseudomembranous colitis
- QT prolongation
- renal disease
- renal failure
- renal impairment
- reproductive risk
- subcutaneous administration
- thyroid disease
- ulcerative colitis
- vancomycin hypersensitivity
- ventricular dysfunction
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Aclidinium; Formoterol
- Acyclovir
- Adefovir
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amikacin
- Aminoglycosides
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Anagrelide
- Angiotensin-converting enzyme inhibitors
- Antithrombin III
- Apixaban
- Apomorphine
- Arformoterol
- Argatroban
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atomoxetine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Azithromycin
- Bacitracin
- Bedaquiline
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bivalirudin
- Budesonide; Formoterol
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Celecoxib
- Ceritinib
- Chloroquine
- Chlorpromazine
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Ciprofloxacin
- Cisapride
- Cisplatin
- Citalopram
- Clarithromycin
- Class IA Antiarrhythmics
- Clofazimine
- Clomipramine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crizotinib
- Cyclosporine
- Dabigatran
- Danaparoid
- Dasatinib
- Degarelix
- Desipramine
- Desirudin
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Entrectinib
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esomeprazole; Naproxen
- Ethacrynic Acid
- Etodolac
- Ezogabine
- Famotidine; Ibuprofen
- Fenoprofen
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Ganciclovir
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gentamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Halogenated Anesthetics
- Haloperidol
- Heparin
- Histrelin
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrocodone; Ibuprofen
- Hydroxychloroquine
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Ibutilide
- Iloperidone
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indomethacin
- Inotuzumab Ozogamicin
- Itraconazole
- Ivosidenib
- Kanamycin
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lapatinib
- Lefamulin
- Lenvatinib
- Lepirudin
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levofloxacin
- Lisinopril
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Low Molecular Weight Heparins
- Macimorelin
- Magnesium Salicylate
- Maprotiline
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Meperidine; Promethazine
- Metaproterenol
- Methadone
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Moexipril
- Moxifloxacin
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nilotinib
- Nonsteroidal antiinflammatory drugs
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ondansetron
- Oral Contraceptives
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Ozanimod
- Paliperidone
- Pamidronate
- Panobinostat
- Paromomycin
- Pasireotide
- Pazopanib
- Pentamidine
- Pentosan
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pirbuterol
- Piroxicam
- Pitolisant
- Plazomicin
- Polymyxin B
- Polymyxins
- Posaconazole
- Primaquine
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinapril
- Quinine
- Ramipril
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Rivaroxaban
- Rofecoxib
- Romidepsin
- Salicylates
- Salmeterol
- Salsalate
- Saquinavir
- Selpercatinib
- Sertraline
- Short-acting beta-agonists
- Siponimod
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Sorafenib
- Sotalol
- Streptomycin
- Streptozocin
- Sulindac
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telithromycin
- Terbutaline
- Tetrabenazine
- Thioridazine
- Tiotropium; Olodaterol
- Tobramycin
- Tolmetin
- Tolterodine
- Toremifene
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triptorelin
- Umeclidinium; Vilanterol
- Valdecoxib
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Voriconazole
- Vorinostat
- Warfarin
- Ziprasidone
- Zoledronic Acid
