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What is Tegaserod
Tegaserod is a selective serotonin (5HT-4) partial agonist belonging to a chemical class known as the aminoguanidine indoles.
Tegaserod is indicated for the treatment of adult women less than 65 years of age with irritable bowel syndrome with constipation (IBS-C).
Tegaserod has been shown to be effective in treating abdominal pain, altered bowel habit (decreased stool frequency, hardened stool consistency, straining), and bloating associated with constipation-predominant IBS
Brand Name
Zelnorm
Indications
- irritable bowel syndrome
For the treatment irritable bowel syndrome (IBS) in women whose predominant bowel symptom is constipation
Side Effects
- abdominal pain
- alopecia
- anaphylactoid reactions
- anemia
- appetite stimulation
- arthropathy
- asthenia
- bowel ischemia
- bowel necrosis
- chest pain (unspecified)
- cholecystitis
- cholelithiasis
- colitis
- depression
- diarrhea
- dizziness
- dyspepsia
- elevated hepatic enzymes
- flatulence
- GI bleeding
- headache
- hepatitis
- hypokalemia
- ischemic colitis
- migraine
- myocardial infarction
- nausea
- orthostatic hypotension
- stroke
- suicidal ideation
- syncope
- vertigo
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abdominal pain
- angina
- breast-feeding
- cardiac disease
- children
- colitis
- coronary artery disease
- depression
- diabetes mellitus
- diarrhea
- gallbladder disease
- geriatric
- GI bleeding
- GI disease
- GI obstruction
- hepatic disease
- hyperlipidemia
- hypertension
- hypotension
- hypovolemia
- infants
- ischemic colitis
- myocardial infarction
- neonates
- obesity
- pregnancy
- renal disease
- renal impairment
- stroke
- suicidal ideation
- syncope
- tobacco smoking
Interactions
- Acarbose
- Acetohexamide
- Albiglutide
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Anticholinergics
- Atenolol; Chlorthalidone
- Azilsartan; Chlorthalidone
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Chlorothiazide
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Digoxin
- Dulaglutide
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Exenatide
- Fosinopril; Hydrochlorothiazide, HCTZ
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Incretin Mimetics
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lixisenatide
- Meglitinides
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methyclothiazide
- Metolazone
- Miglitol
- Nateglinide
- Pioglitazone
- Repaglinide
- Rosiglitazone
- Saxagliptin
- Semaglutide
- Simvastatin; Sitagliptin
- Sitagliptin
- Solifenacin
- Sulfonylureas
- Thiazide diuretics
- Tolazamide
- Tolbutamide
- Tolterodine
- Trospium
