Tafenoquine

What is Tafenoquine

Tafenoquine is an oral antimalarial indicated for malaria prophylaxis in adults and for the radical cure (prevention of relapse) of Plasmodium vivax malaria in patients aged 16 years and older who are receiving appropriate antimalarial therapy for acute P. vivax infection.

Tafenoquine is not indicated for the acute treatment of P. vivax infection. Screening of all patients for glucose-6-phosphate dehydrogenase (G6PD) deficiency is necessary prior to tafenoquine use due to the risk for hemolytic anemia.

Psychiatric adverse events have occurred with tafenoquine use and are more common in patients with a history of psychotic disorders.

Due to the long half-life of tafenoquine, signs or symptoms of psychiatric events could be delayed in onset and/or duration.

Brand Names

  • Arakoda
  • KRINTAFEL

Indications

  1. malaria
  2. malaria prophylaxis
  3. Plasmodium falciparum
  4. Plasmodium vivax

Monitoring Parameters

  • glucose-6-phosphate dehydrogenase (G6PD) activity
  • pregnancy testing

Contraindications

  • breast-feeding
  • contraception requirements
  • G6PD deficiency
  • hepatic disease
  • iodoquinol hypersensitivity
  • methemoglobin reductase deficiency
  • pregnancy
  • pregnancy testing
  • primaquine hypersensitivity
  • psychiatric event
  • psychosis
  • renal disease
  • renal failure
  • renal impairment
  • reproductive risk

Interactions

  • Alogliptin; Metformin
  • Canagliflozin; Metformin
  • Dapagliflozin; Metformin
  • Dofetilide
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Ertugliflozin; Metformin
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Linagliptin; Metformin
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Penicillamine
  • Pramipexole
  • Rabies Vaccine
  • Varenicline
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