Salmeterol

What is Salmeterol

Salmeterol is an inhaled long-acting inhaled beta-2 agonist (LABA) that is given twice daily.

It is indicated for the maintenance treatment of asthma in combination with an asthma controller medication (i.e., inhaled corticosteroid [ICS]), for the prevention of exercise-induced bronchospasm (EIB), and for the maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD).

The oral powder for inhalation (Serevent Diskus) is approved in adults and pediatric patients as young as 4 years of age.

Brand Name

  • Serevent
  • Serevent Diskus

Indications

  • altitude sickness prophylaxis
  • asthma
  • bronchospasm prophylaxis
  • chronic bronchitis
  • chronic obstructive pulmonary disease (COPD)
  • emphysema
  • exercise-induced bronchospasm prophylaxis

Side Effects

  1. anaphylactoid reactions
  2. angina
  3. angioedema
  4. anxiety
  5. arthralgia
  6. asthma-related death
  7. bone pain
  8. bronchospasm
  9. candidiasis
  10. contact dermatitis
  11. cough
  12. dental pain
  13. dizziness
  14. dyspepsia
  15. elevated hepatic enzymes
  16. fatigue
  17. headache
  18. hyperglycemia
  19. hypertension
  20. hypokalemia
  21. hypotension
  22. infection
  23. influenza
  24. insomnia
  25. laryngospasm
  26. malaise
  27. migraine
  28. muscle cramps
  29. musculoskeletal pain
  30. nasal congestion
  31. nausea
  32. palpitations
  33. paresthesias
  34. pharyngitis
  35. QT prolongation
  36. rash
  37. rhinitis
  38. sinus tachycardia
  39. sinusitis
  40. tracheitis
  41. tremor
  42. urticaria
  43. vomiting
  44. wheezing
  45. xerostomia

Monitoring Parameters

  • pulmonary function tests (PFTs)

Contraindications

  • acute bronchospasm
  • alcoholism
  • asthma-related death
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • coronary artery disease
  • diabetes mellitus
  • females
  • geriatric
  • heart failure
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • infants
  • labor
  • malnutrition
  • MAOI therapy
  • milk protein hypersensitivity
  • monotherapy treatment of asthma
  • myocardial infarction
  • paradoxical bronchospasm
  • pheochromocytoma
  • pregnancy
  • QT prolongation
  • seizure disorder
  • seizures
  • status asthmaticus
  • tachycardia
  • thyroid disease
  • thyrotoxicosis

Interactions

  • Abarelix
  • Acebutolol
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  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
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  • Acetaminophen; Caffeine; Dihydrocodeine
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  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
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