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What is Streptomycin
Streptomycin is a parenteral aminoglycoside antibiotic derived from cultures of Streptomyces griseus. It was the first of the aminoglycosides to be isolated and used therapeutically.
Clinical use of streptomycin includes Mycobacterium tuberculosis infections (second- or third-line agent), tularemia (Francisella tularensis), plague (Yersinia pestis), and, until recently, in combination with a penicillin for the treatment of endocarditis.
Due to resistant organisms, a higher risk of irreversible vestibular toxicity, and the inability to monitor serum concentrations in most institutions, other aminoglycoside agents, such as gentamicin or tobramycin, are more desirable. Streptomycin was approved by the FDA in 1945.
Indications & Dosage
- Acinetobacter sp.
- Actinomadura madurae
- Actinomadura pelletierii
- actinomycotic mycetoma
- Bacillus anthracis
- bacteremia
- Brucella sp.
- brucellosis
- Burkholderia mallei
- chancroid
- Citrobacter sp.
- endocarditis
- Enterococcus faecalis
- Erysipelothrix sp.
- Escherichia coli
- Francisella tularensis
- granuloma inguinale
- Haemophilus ducreyi
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella aerogenes
- Klebsiella granulomatis
- Klebsiella pneumoniae
- lower respiratory tract infections
- meningitis
- Mycobacterium avium
- Mycobacterium avium complex infection
- Mycobacterium bovis
- Mycobacterium intracellulare
- Mycobacterium kansasii
- Mycobacterium leprae
- Mycobacterium marinum
- Mycobacterium tuberculosis
- Nocardia brasiliensis
- Nocardia sp.
- Pasteurella multocida
- plague
- pneumonia
- Proteus sp.
- Providencia sp.
- Salmonella sp.
- Serratia sp.
- Shigella sp.
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptomyces somaliensis
- tuberculosis infection
- tularemia
- tularemia prophylaxis
- urinary tract infection (UTI)
- Viridans streptococci
- Yersinia pestis
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- amblyopia
- anaphylactoid reactions
- angioedema
- arachnoiditis
- azotemia
- cylindruria
- encephalopathy
- eosinophilia
- exfoliative dermatitis
- fever
- hearing loss
- hemolytic anemia
- hyposthenuria
- injection site reaction
- leukopenia
- nephrotoxicity
- neuritis
- neurotoxicity
- ototoxicity
- pancytopenia
- paresthesias
- proteinuria
- pyuria
- rash
- renal tubular acidosis (RTA)
- renal tubular necrosis
- thrombocytopenia
- tinnitus
- urticaria
- vitamin B12 deficiency
- vitamin B6 deficiency
- weakness
Monitoring Parameters
- audiometry
- serum creatinine/BUN
Contraindications
- aminoglycoside hypersensitivity
- botulism
- breast-feeding
- colitis
- dehydration
- diarrhea
- geriatric
- GI disease
- hearing impairment
- infants
- inflammatory bowel disease
- intravenous administration
- myasthenia gravis
- neonates
- nephrotoxicity
- neuromuscular blockade
- neurotoxicity
- ototoxicity
- parkinsonism
- pregnancy
- pseudomembranous colitis
- renal disease
- renal failure
- renal impairment
- requires a specialized care setting
- respiratory depression
- respiratory insufficiency
- sexually transmitted disease
- tinnitus
- ulcerative colitis
- viral infection
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Diphenhydramine
- Acyclovir
- Adefovir
- Aldesleukin, IL-2
- Aminosalicylate sodium, Aminosalicylic acid
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Aprotinin
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atracurium
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Bacillus Calmette-Guerin Vaccine, BCG
- Bacitracin
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Beractant
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bleomycin
- Botulinum Toxins
- Bumetanide
- Calfactant
- Capreomycin
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carboplatin
- Cefepime
- Cefotaxime
- Cefotetan
- Cefoxitin
- Cefprozil
- Ceftazidime
- Ceftazidime; Avibactam
- Ceftizoxime
- Cefuroxime
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cisatracurium
- Cisplatin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colfosceril; Cetyl Alcohol; Tyloxapol
- Cyclizine
- Cyclosporine
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Deferasirox
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxacurium
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enflurane
- Entecavir
- Ethacrynic Acid
- Etomidate
- Fluphenazine
- Foscarnet
- Fospropofol
- Furosemide
- Gallium
- Gallium Ga 68 Dotatate
- Ganciclovir
- General anesthetics
- Ginger, Zingiber officinale
- Gold
- Halothane
- Hyaluronidase, Recombinant; Immune Globulin
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibandronate
- Ibuprofen lysine
- Immune Globulin IV, IVIG, IGIV
- Inotersen
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Isoflurane
- Isosulfan Blue
- Ketamine
- Lamivudine; Tenofovir Disoproxil Fumarate
- Magnesium Salicylate
- Mannitol
- Meclizine
- Meperidine; Promethazine
- Mesoridazine
- Methohexital
- Mivacurium
- Neuromuscular blockers
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Oral Contraceptives
- Pamidronate
- Pancuronium
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Polymyxin B
- Polymyxins
- Poractant Alfa
- Promethazine
- Propofol
- Pyridostigmine
- Rapacuronium
- Rocuronium
- Salicylates
- Salsalate
- Scopolamine
- Sevoflurane
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Streptozocin
- Succinylcholine
- Surfactants
- Tacrolimus
- Telavancin
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Thiopental
- Thioridazine
- Torsemide
- Trifluoperazine
- Trimethobenzamide
- Tubocurarine
- Urea
- Valacyclovir
- Valganciclovir
- Vancomycin
- Vecuronium
- Vitamin C
- Warfarin
- Zalcitabine, ddC
- Zoledronic Acid
