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What is Stavudine d4T
Stavudine d4T is an oral antiretroviral nucleoside reverse transcriptase inhibitor (NRTI). It is a synthetic thymidine nucleoside analog used in combination with other agents to treat HIV-infected patients.
Stavudine is indicated as part of combination therapy for the treatment of HIV infection; it is not recommended to be given as monotherapy.
Concurrent administration of stavudine and didanosine is contraindicated due to the potential for toxicity; concurrent treatment with zidovudine should also be avoided because of the potential for virologic antagonism.
Brand Names
- Zerit
- Zerit XR
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
Side Effects
- abdominal pain
- anemia
- anorexia
- chills
- diabetes mellitus
- diarrhea
- dyspnea
- elevated hepatic enzymes
- fatigue
- fever
- Guillain-Barre syndrome
- headache
- hepatic failure
- hepatitis
- hepatomegaly
- hepatotoxicity
- hyperamylasemia
- hyperbilirubinemia
- hyperglycemia
- insomnia
- lactic acidosis
- leukopenia
- lipodystrophy
- macrocytosis
- myalgia
- nausea
- neutropenia
- pancreatitis
- peripheral neuropathy
- rash
- steatosis
- tachypnea
- thrombocytopenia
- vomiting
- weakness
- weight loss
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- platelet count
- pregnancy testing
- serum amylase
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine
- serum lipase
- serum lipid profile
- urinalysis
Contraindications
- alcoholism
- autoimmune disease
- breast-feeding
- dialysis
- females
- geriatric
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis C and HIV coinfection
- hepatotoxicity or lactic acidosis
- human immunodeficiency virus (HIV) infection resistance
- immune reconstitution syndrome
- neuromuscular disease
- obesity
- pancreatitis
- peripheral neuropathy
- pregnancy
- renal failure
- renal impairment
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Adefovir
- Bortezomib
- Colchicine; Probenecid
- Didanosine, ddI
- Doxorubicin
- Echinacea
- food
- Hydroxyurea
- Interferon Alfa-2b; Ribavirin
- Interferons
- Lamivudine, 3TC; Zidovudine, ZDV
- Methadone
- Orlistat
- Probenecid
- Ribavirin
- Zalcitabine, ddC
- Zidovudine, ZDV
