Spirapril

What is Spirapril

NOTE: Not currently available in the US.

Spirapril is an oral angiotensin-converting enzyme inhibitor. It is a carboxyl-containing ACE inhibitor, similar to ramipril and benazepril. Spirapril is a prodrug which is rapidly absorbed and hydrolyzed to an active diacid, spiraprilat.

Spiraprilat has a short plasma half-life, but a prolonged duration of ACE inhibition and clinical activity, allowing once daily administration.

At this time, spirapril is approved only for use in hypertension; however, because its mechanism of action differs little from other currently approved ACE inhibitors, it is likely to be approved for other conditions in the future. Spirapril was approved December 29, 1994, however Sandoz is not currently marketing this agent in the United States.

Indications & Dosage

  • hypertension

Side Effects

  • anaphylactoid reactions
  • angioedema
  • azotemia
  • back pain
  • cholestasis
  • conjunctivitis
  • cough
  • dizziness
  • fatigue
  • headache
  • hepatic failure
  • hepatic necrosis
  • hepatitis
  • hyperkalemia
  • hypotension
  • infection
  • jaundice
  • orthostatic hypotension
  • paresthesias
  • sinus tachycardia
  • syncope
  • teratogenesis

Monitoring Parameters

  • serum creatinine/BUN
  • serum potassium
  • serum sodium

Contraindications

  • ACE-inhibitor induced angioedema
  • angioedema
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
  • aortic stenosis
  • autoimmune disease
  • Black patients
  • bone marrow suppression
  • breast-feeding
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • collagen-vascular disease
  • coronary artery disease
  • dialysis
  • geriatric
  • heart failure
  • hepatic disease
  • hereditary angioedema
  • history of angioedema
  • hymenoptera venom (insect sting) allergy desensitization
  • hyperkalemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • immunosuppression
  • low-density lipoprotein apheresis
  • pregnancy
  • renal artery stenosis
  • renal disease
  • renal failure
  • renal impairment

Interactions

No information is available regarding drug interactions associated with Spirapril 

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