Sparfloxacin

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What is Sparfloxacin

Description

NOTE: This drug is discontinued in the US.

Description: Sparfloxacin is an oral fluoroquinolone antibiotic approved for the treatment of community-acquired pneumonia and acute bacterial exacerbations of chronic bronchitis.

Sparfloxacin is less active than ciprofloxacin against Pseudomonas aeruginosa and some other gram-negative bacilli. Sparfloxacin has a longer half-life than ciprofloxacin and can be administered once daily. Unlike ciprofloxacin, sparfloxacin does not interact significantly with theophylline.

Phototoxicity is more common with sparfloxacin and lomefloxacin than with other fluoroquinolones. QT prolongation may also occur with use of sparfloxacin; therefore, its use is contraindicated in patients receiving other drugs that can prolong the QTc interval.

Sparfloxacin was granted final FDA approval for community-acquired pneumonia and chronic bronchitis on December 19, 1996.

Brand Name

Zagam

Indications & Dosage

  • Acinetobacter anitratus
  • Acinetobacter lwoffii
  • bronchitis
  • Chlamydia trachomatis
  • Chlamydophila pneumoniae
  • Citrobacter diversus
  • community-acquired pneumonia
  • Enterobacter cloacae
  • Haemophilus influenzae (beta-lactamase negative)
  • Haemophilus influenzae (beta-lactamase positive)
  • Haemophilus parainfluenzae
  • Klebsiella aerogenes
  • Klebsiella oxytoca
  • Klebsiella pneumoniae
  • Legionella pneumophila
  • Moraxella catarrhalis
  • Morganella morganii
  • Mycobacterium leprae
  • Mycobacterium tuberculosis
  • Mycoplasma pneumoniae
  • Neisseria gonorrhoeae
  • Proteus mirabilis
  • Proteus vulgaris
  • Staphylococcus aureus (MSSA)
  • Streptococcus agalactiae (group B streptococci)
  • Streptococcus pneumoniae
  • Streptococcus pyogenes (group A beta-hemolytic streptococci)
  • Viridans streptococci

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactic shock
  4. anemia
  5. angioedema
  6. anxiety
  7. aplastic anemia
  8. asthenia
  9. azotemia
  10. bronchospasm
  11. confusion
  12. depression
  13. diarrhea
  14. dizziness
  15. drowsiness
  16. dysgeusia
  17. dyspepsia
  18. dyspnea
  19. fever
  20. flatulence
  21. hallucinations
  22. headache
  23. hemolytic anemia
  24. hepatic failure
  25. hepatitis
  26. increased intracranial pressure
  27. insomnia
  28. interstitial nephritis
  29. jaundice
  30. leukopenia
  31. maculopapular rash
  32. nausea
  33. nightmares
  34. pancytopenia
  35. paranoia
  36. photosensitivity
  37. pneumonitis
  38. pruritus
  39. pseudomembranous colitis
  40. QT prolongation
  41. restlessness
  42. seizures
  43. Stevens-Johnson syndrome
  44. suicidal ideation
  45. tendon rupture
  46. thrombocytopenia
  47. thrombotic thrombocytopenic purpura (TTP)
  48. torsade de pointes
  49. toxic epidermal necrolysis
  50. tremor
  51. urticaria
  52. vomiting
  53. xerostomia

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN

Contraindications

  • atrial fibrillation
  • bradycardia
  • breast-feeding
  • cardiac disease
  • cerebrovascular disease
  • children
  • colitis
  • corticosteroid therapy
  • diarrhea
  • geriatric
  • GI disease
  • heart failure
  • hypokalemia
  • inflammatory bowel disease
  • myasthenia gravis
  • organ transplant
  • pregnancy
  • pseudomembranous colitis
  • QT prolongation
  • quinolone hypersensitivity
  • renal impairment
  • seizure disorder
  • sunlight (UV) exposure
  • tendinitis
  • tendinopathy
  • tendon pain
  • tendon rupture
  • ulcerative colitis
  • viral infection

Interactions

  • Abarelix
  • Acetohexamide
  • Alfuzosin
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apomorphine
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Bepridil
  • Canagliflozin; Metformin
  • Chloroprocaine
  • Chlorpromazine
  • Chlorpropamide
  • Cisapride
  • Clarithromycin
  • Class IA Antiarrhythmics
  • Clomipramine
  • Clozapine
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Desipramine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Didanosine, ddI
  • Disopyramide
  • Dolasetron
  • Doxepin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enflurane
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Flecainide
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Imipramine
  • Incretin Mimetics
  • Insulins
  • Isoflurane
  • Levomethadyl
  • Linagliptin
  • Linagliptin; Metformin
  • Maprotiline
  • Mefloquine
  • Meperidine; Promethazine
  • Mesoridazine
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Nortriptyline
  • Octreotide
  • Olanzapine
  • Ondansetron
  • Paliperidone
  • Pentamidine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenothiazines
  • Phenylephrine; Promethazine
  • Pimozide
  • Posaconazole
  • Pramlintide
  • Procainamide
  • Procaine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Ranolazine
  • Saquinavir
  • Saxagliptin
  • Sevoflurane
  • SGLT2 Inhibitors
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sulfonylureas
  • Tacrolimus
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Tetracaine
  • Thiazolidinediones
  • Thiethylperazine
  • Thioridazine
  • Tolazamide
  • Tolbutamide
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
  • Vardenafil
  • Vorinostat
  • Ziprasidone

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