Ropinirole

What is Ropinirole

Ropinirole is an oral non-ergot alkaloid dopamine agonist.

It is indicated for the treatment of signs and symptoms associated with idiopathic Parkinson’s disease in adults, both as early monotherapy and in combination with levodopa.

As with other dopamine agonists, the drug has also proven effective for treating restless leg syndrome (RLS) in adults.

When used as monotherapy in patients with Parkinson’s disease, ropinirole may delay the need for levodopa therapy, thus indicating its usefulness in the early stages of the disease.

FDA approval of ropinirole was initially granted in 1997.

Brand Name

• Requip
• Requip XL

Indications

• Parkinson’s disease
• restless legs syndrome (RLS)

Side Effects

1. abdominal pain
2. abnormal dreams
3. amnesia
4. anemia
5. angioedema
6. anorexia
7. anxiety
8. arthralgia
9. asthenia
10. atrial fibrillation
11. back pain
12. bradycardia
13. chest pain (unspecified)
14. confusion
15. constipation
16. cough
17. diarrhea
18. diplopia
19. dizziness
20. drowsiness
21. dyskinesia
22. dyspepsia
23. dysphagia
24. dyspnea
25. edema
26. flatulence
27. flushing
28. hallucinations
29. headache
30. hyperesthesia
31. hyperhidrosis
32. hyperkinesis
33. hypersalivation
34. hypertension
35. hypotension
36. impotence (erectile dysfunction)
37. impulse control symptoms
38. influenza
39. insomnia
40. lethargy
41. muscle cramps
42. nasal congestion
43. nausea
44. neuroleptic malignant syndrome-like symptoms
45. new primary malignancy
46. orthostatic hypotension
47. palpitations
48. paresis
49. paresthesias
50. peripheral edema
51. pharyngitis
52. pruritus
53. pyuria
54. rash
55. restless legs syndrome (RLS) augmentation
56. restless legs syndrome (RLS) rebound
57. rhinitis
58. sinus tachycardia
59. sinusitis
60. sudden sleep onset
61. syncope
62. tremor
63. urinary incontinence
64. urticaria
65. vertigo
66. visual impairment
67. vomiting
68. weight loss
69. withdrawal
70. xerophthalmia
71. xerostomia
72. yawning

Monitoring Parameters

• LFTs

Contraindications

• abrupt discontinuation
• breast-feeding
• cardiac disease
• children
• coadministration with other CNS depressants
• dialysis
• driving or operating machinery
• ethanol ingestion
• geriatric
• hepatic disease
• hypertension
• hypotension
• impulse control symptoms
• melanoma
• narcolepsy
• orthostatic hypotension
• pregnancy
• psychosis
• renal failure
• renal impairment
• sleep apnea
• syncope
• tobacco smoking

Interactions

• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Tramadol
• Albendazole
• Alprazolam
• Amiodarone
• Amitriptyline; Chlordiazepoxide
• Amobarbital
• Amoxapine
• Anagrelide
• Apomorphine
• Aripiprazole
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• atypical antipsychotic
• Azelastine
• Azelastine; Fluticasone
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Benzhydrocodone; Acetaminophen
• Brexpiprazole
• Brompheniramine; Carbetapentane; Phenylephrine
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Butabarbital
• Butorphanol
• Cannabidiol
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Cariprazine
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chloral Hydrate
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chlorpromazine
• Cimetidine
• Ciprofloxacin
• Clobazam
• Clorazepate
• Clozapine
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Conjugated Estrogens
• Conjugated Estrogens; Bazedoxifene
• Conjugated Estrogens; Medroxyprogesterone
• Deutetrabenazine
• Dexmethylphenidate
• Dextromethorphan; Promethazine
• Diazepam
• Dienogest; Estradiol valerate
• Diethylstilbestrol, DES
• Donepezil; Memantine
• Droperidol
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Elagolix; Estradiol; Norethindrone acetate
• Esketamine
• Estazolam
• Esterified Estrogens
• Esterified Estrogens; Methyltestosterone
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Estradiol; Levonorgestrel
• Estradiol; Norethindrone
• Estradiol; Norgestimate
• Estradiol; Progesterone
• Estrogens
• Estropipate
• Eszopiclone
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluvoxamine
• Gabapentin
• Haloperidol
• Iloperidone
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Lasmiditan
• Lemborexant
• Levocetirizine
• Lofexidine
• Lorazepam
• Loxapine
• Lumateperone
• Lurasidone
• Maprotiline
• Memantine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Mesoridazine
• Mestranol; Norethindrone
• Methohexital
• Methylphenidate
• Metoclopramide
• Metyrapone
• Mexiletine
• Mirtazapine
• Molindone
• Nabilone
• Norfloxacin
• Obeticholic Acid
• Olanzapine
• Opiate Agonists
• Oxazepam
• Paliperidone
• Peginterferon Alfa-2b
• Pentobarbital
• Perampanel
• Perphenazine
• Perphenazine; Amitriptyline
• Phenobarbital
• Phenothiazines
• Phenylephrine; Promethazine
• Pimozide
• Pregabalin
• Primidone
• Prochlorperazine
• Promethazine
• Quazepam
• Quetiapine
• Rifampin
• Risperidone
• Rucaparib
• Secobarbital
• Sedating H1-blockers
• Segesterone Acetate; Ethinyl Estradiol
• Simeprevir
• Solriamfetol
• Suvorexant
• Tacrine
• Tapentadol
• Teriflunomide
• Thalidomide
• Thiabendazole
• Thiethylperazine
• Thiopental
• Thioridazine
• Thiothixene
• tobacco
• Tramadol
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Vemurafenib
• Warfarin
• Zaleplon
• Ziconotide
• Zileuton
• Ziprasidone
• Zolpidem