Risperidone

What is Risperidone

Risperidone is an atypical antipsychotic of the benzisoxazole class.

Atypical antipsychotics such as risperidone are first-line treatment options for the management of schizophrenia and related disorders, with the exception of clozapine.

Risperidone is used clinically in adults for schizophrenia and acute manic or mixed episodes associated with bipolar I disorder, as monotherapy or as adjunctive treatment.

Oral formulations of risperidone are approved to treat pediatric patients with the following conditions: irritability associated with autistic disorder in pediatric patients 5 years of age and older, schizophrenia in adolescents, and acute manic or mixed episodes associated with bipolar I disorder in pediatric patients 10 years of age and older.

Indications & Dosage

• autistic disorder
• behavioral or psychological symptoms of dementia
• bipolar disorder
• delirium
• mania
• oppositional defiant disorder
• schizophrenia
• Tourette’s syndrome

Side Effects

1. abdominal pain
2. acne vulgaris
3. agitation
4. agranulocytosis
5. akathisia
6. akinesia
7. alopecia
8. amenorrhea
9. anaphylactoid reactions
10. anemia
11. angioedema
12. anorexia
13. anxiety
14. apnea
15. appetite stimulation
16. arthralgia
17. asthenia
18. atopic dermatitis
19. atrial fibrillation
20. AV block
21. back pain
22. blepharedema
23. blepharospasm
24. blurred vision
25. bradycardia
26. breast discharge
27. breast enlargement
28. bundle-branch block
29. cardiac arrest
30. cheilitis
31. chest pain (unspecified)
32. chills
33. confusion
34. conjunctival hyperemia
35. conjunctivitis
36. constipation
37. cough
38. cystitis
39. dental pain
40. depression
41. diabetes mellitus
42. diabetic ketoacidosis
43. diarrhea
44. dizziness
45. drowsiness
46. dysarthria
47. dysgeusia
48. dyskinesia
49. dyspepsia
50. dysphagia
51. dysphonia
52. dyspnea
53. dystonic reaction
54. dysuria
55. ecchymosis
56. edema
57. ejaculation dysfunction
58. elevated hepatic enzymes
59. eosinophilia
60. epistaxis
61. erythema
62. fatigue
63. fecal incontinence
64. fever
65. flushing
66. galactorrhea
67. gastritis
68. GI obstruction
69. glycosuria
70. gynecomastia
71. headache
72. hematoma
73. hypercholesterolemia
74. hyperglycemia
75. hyperkeratosis
76. hyperlipidemia
77. hyperprolactinemia
78. hypersalivation
79. hypertension
80. hyperthermia
81. hypertriglyceridemia
82. hyperventilation
83. hypoesthesia
84. hypoglycemia
85. hyponatremia
86. hypotension
87. hypothermia
88. ileus
89. impotence (erectile dysfunction)
90. increased urinary frequency
91. infection
92. infertility
93. influenza
94. injection site reaction
95. insomnia
96. jaundice
97. lacrimation
98. lethargy
99. leukopenia
100. libido decrease
101. maculopapular rash
102. malaise
103. mania
104. mastalgia
105. menorrhagia
106. menstrual irregularity
107. muscle cramps
108. musculoskeletal pain
109. myalgia
110. myasthenia
111. nasal congestion
112. nausea
113. neuroleptic malignant syndrome
114. neutropenia
115. night sweats
116. nocturia
117. ocular discharge
118. ocular hypertension
119. ocular infection
120. oligomenorrhea
121. orgasm dysfunction
122. orthostatic hypotension
123. otalgia
124. pancreatitis
125. paresthesias
126. peripheral edema
127. pharyngitis
128. photophobia
129. photosensitivity
130. pneumonitis
131. polydipsia
132. polyuria
133. precocious puberty
134. priapism
135. pruritus
136. pseudoparkinsonism
137. pulmonary embolism
138. QT prolongation
139. rash
140. restlessness
141. retinal thrombosis
142. rhabdomyolysis
143. rhinitis
144. rhinorrhea
145. seborrhea
146. seizures
147. SIADH
148. sinus tachycardia
149. sinusitis
150. skin discoloration
151. skin hyperpigmentation
152. skin irritation
153. skin ulcer
154. somnambulism
155. Stevens-Johnson syndrome
156. stroke
157. suicidal ideation
158. syncope
159. tardive dyskinesia
160. teeth grinding (bruxism)
161. thrombocytopenia
162. thrombotic thrombocytopenic purpura (TTP)
163. tinnitus
164. tissue necrosis
165. torsade de pointes
166. toxic epidermal necrolysis
167. tremor
168. urinary incontinence
169. urinary retention
170. vaginal discharge
171. vertigo
172. visual impairment
173. vomiting
174. water intoxication
175. weight gain
176. weight loss
177. wheezing
178. withdrawal
179. xerophthalmia
180. xerosis
181. xerostomia

Monitoring Parameters

• AIMS assessment
• blood glucose
• CBC
• glycosylated hemoglobin A1c (HbA1c)
• LFTs
• neurologic function
• pregnancy testing
• serum creatinine
• serum electrolytes
• serum lipid profile
• serum prolactin
• thyroid function tests (TFTs)
• weight

Contraindications

• abrupt discontinuation
• agranulocytosis
• alcoholism
• ambient temperature increase
• bradycardia
• breast cancer
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cerebrovascular disease
• children
• CNS depression
• coadministration with other CNS depressants
• coronary artery disease
• dehydration
• dementia
• diabetes mellitus
• diabetic ketoacidosis
• driving or operating machinery
• dysphagia
• ethanol ingestion
• females
• geriatric
• heart failure
• hematological disease
• hepatic disease
• hypercholesterolemia
• hyperglycemia
• hyperlipidemia
• hyperosmolar hyperglycemic state (HHS)
• hyperprolactinemia
• hypertension
• hyperthermia
• hypertriglyceridemia
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypothermia
• hypovolemia
• infants
• infertility
• leukopenia
• long QT syndrome
• malnutrition
• myocardial infarction
• neonates
• neurological disease
• neutropenia
• obesity
• orthostatic hypotension
• Parkinson’s disease
• phenylketonuria
• pregnancy
• pregnancy testing
• priapism
• QT prolongation
• renal disease
• renal failure
• renal impairment
• seizure disorder
• seizures
• serious hypersensitivity reactions or anaphylaxis
• strenuous exercise
• stroke
• suicidal ideation
• syncope
• tardive dyskinesia
• thrombotic thrombocytopenic purpura (TTP)
• thyroid disease

Interactions

• Abarelix
• Acarbose
• Acebutolol
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Aldesleukin, IL-2
• Alfentanil
• Alfuzosin
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Alprazolam
• Amifampridine
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Anagrelide
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Apalutamide
• Apomorphine
• Arformoterol
• Aripiprazole
• Arsenic Trioxide
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir
• Atazanavir; Cobicistat
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• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azithromycin
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• Bedaquiline
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Bendroflumethiazide; Nadolol
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• Benzodiazepines
• Bepridil
• Betaxolol
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Boceprevir
• Brexpiprazole
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide; Formoterol
• Bumetanide
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Cabergoline
• Cabozantinib
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Cannabidiol
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
• Carteolol
• Carvedilol
• Cenobamate
• Central-acting adrenergic agents
• Ceritinib
• Cetirizine
• Cetirizine; Pseudoephedrine
• Cetrorelix
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlorcyclizine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroquine
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Cinacalcet
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clemastine
• Clevidipine
• Clobazam
• Clofazimine
• Clomipramine
• Clonazepam
• Clorazepate
• Clozapine
• Cobicistat
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
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• Cyclizine
• Cyproheptadine
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• Dapagliflozin; Metformin
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• Darunavir
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• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Dasatinib
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• Desipramine
• Desvenlafaxine
• Deutetrabenazine
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmethylphenidate
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Dimenhydrinate
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
• Dofetilide
• Dolasetron
• Dolutegravir; Rilpivirine
• Donepezil
• Donepezil; Memantine
• Dopamine
• Dorzolamide; Timolol
• Doxazosin
• Doxepin
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Dulaglutide
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elbasvir; Grazoprevir
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril; Felodipine
• Encainide
• Encorafenib
• Entacapone
• Entrectinib
• Enzalutamide
• Epinephrine
• Eplerenone
• Epoprostenol
• Eribulin
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esketamine
• Esmolol
• Estazolam
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Ethotoin
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• Ezogabine
• Felodipine
• Fentanyl
• Fingolimod
• Flecainide
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• food
• Formoterol
• Formoterol; Mometasone
• Fosamprenavir
• Foscarnet
• Fosphenytoin
• Furosemide
• Gabapentin
• Ganirelix
• Gemifloxacin
• Gemtuzumab Ozogamicin
• Gilteritinib
• Glasdegib
• Glecaprevir; Pibrentasvir
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• Goserelin
• Granisetron
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Halofantrine
• Halogenated Anesthetics
• Haloperidol
• Histrelin
• Homatropine; Hydrocodone
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxychloroquine
• Hydroxyzine
• Ibuprofen; Oxycodone
• Ibutilide
• Iloperidone
• Imipramine
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Inotuzumab Ozogamicin
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Isocarboxazid
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isradipine
• Itraconazole
• Ivosidenib
• Ketoconazole
• Labetalol
• Lapatinib
• Lasmiditan
• Ledipasvir; Sofosbuvir
• Lefamulin
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• Leuprolide; Norethindrone
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• Levodopa
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• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Liraglutide
• Lithium
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• Loperamide
• Loperamide; Simethicone
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• Lorazepam
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• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
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• Metoclopramide
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• Metronidazole
• Midazolam
• Midostaurin
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• Morphine; Naltrexone
• Moxifloxacin
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• Nadolol
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• Nateglinide
• Nebivolol
• Nebivolol; Valsartan
• Nicardipine
• Nifedipine
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• Nimodipine
• Nisoldipine
• Non-Ionic Contrast Media
• Norfloxacin
• Nortriptyline
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• Olanzapine
• Olodaterol
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• Ondansetron
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• Oxazepam
• Oxycodone
• Oxymorphone
• Ozanimod
• Paliperidone
• Panobinostat
• Paroxetine
• Pasireotide
• Pazopanib
• Penbutolol
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phenoxybenzamine
• Phentolamine
• Phenylephrine; Promethazine
• Phenytoin
• Pimavanserin
• Pimozide
• Pindolol
• Pioglitazone
• Pirbuterol
• Pitolisant
• Posaconazole
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• Pramipexole
• Pramlintide
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• Prilocaine; Epinephrine
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• Quazepam
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• Ribociclib; Letrozole
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