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What is Riociguat
Riociguat is an oral soluble guanylate cyclase stimulator and is indicated for the treatment of adults with pulmonary arterial hypertension (PAH) (WHO group I) and patients with persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) (WHO Group 4) after surgical treatment or inoperable CTEPH.
Riociguat is the first FDA-approved soluble guanylate cyclase stimulator to treat PAH and the first drug of any class to show efficacy for patients with CTEPH.
Brand Name
Adempas
Indications & Dosage
- pulmonary hypertension
For the treatment of pulmonary hypertension in patients with persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH), (WHO Group 4) after surgical treatment, or inoperable CTEPH, to improve exercise capacity and WHO functional class or pulmonary arterial hypertension (PAH), (WHO Group 1), to improve exercise capacity, WHO functional class and to delay clinical worsening
Side Effects
- anemia
- bleeding
- constipation
- diarrhea
- dizziness
- dyspepsia
- dysphagia
- epistaxis
- gastritis
- gastroesophageal reflux
- headache
- hematemesis
- hemoptysis
- hypotension
- nasal congestion
- nausea
- palpitations
- peripheral edema
- pulmonary edema
- spontaneous fetal abortion
- subdural hematoma
- teratogenesis
- vaginal bleeding
- vomiting
Monitoring Parameters
- blood pressure
- pregnancy testing
Contraindications
- breast-feeding
- contraception requirements
- hypotension
- hypovolemia
- idiopathic interstitial pneumonia
- pregnancy
- pregnancy testing
- pulmonary edema
- reproductive risk
- tobacco smoking
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amphetamine
- Amphetamine; Dextroamphetamine
- Antacids
- Apalutamide
- Aprepitant, Fosaprepitant
- Articaine; Epinephrine
- Aspirin, ASA; Dipyridamole
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzphetamine
- Boceprevir
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cilostazol
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Daclatasvir
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Dobutamine
- Dopamine
- Duloxetine
- Elbasvir; Grazoprevir
- Enzalutamide
- Ephedrine
- Epinephrine
- Fexofenadine; Pseudoephedrine
- Fosamprenavir
- Fosphenytoin
- Gemfibrozil
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Itraconazole
- Ketoconazole
- Lisdexamfetamine
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lurasidone
- Magnesium Hydroxide
- Mepivacaine; Levonordefrin
- Methamphetamine
- Methylphenidate
- Midodrine
- Milrinone
- Mitotane
- Naproxen; Pseudoephedrine
- Nefazodone
- Nitrates
- Norepinephrine
- Ombitasvir; Paritaprevir; Ritonavir
- Pemoline
- Phendimetrazine
- Phenobarbital
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Prilocaine; Epinephrine
- Pseudoephedrine
- Racepinephrine
- Rifampin
- Ritodrine
- Ritonavir
- Roflumilast
- Sapropterin
- Sildenafil
- Sofosbuvir; Velpatasvir; Voxilaprevir
- St. John’s Wort, Hypericum perforatum
- Sympathomimetics
- Tadalafil
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Theophylline, Aminophylline
- Tipranavir
- tobacco
- Tucatinib
- Vardenafil
- Zafirlukast
- Zonisamide
