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What is Riluzole
Riluzole is an oral glutamate antagonist approved for the treatment of amyotrophic lateral sclerosis (ALS).
Riluzole does not cure the disease or improve symptoms, but it might prolong the survival of patients by approximately 3 months.
Riluzole appears to be more effective in patients with bulbar-onset disease than for those with limb-onset disease.
Riluzole has been used off-label for the treatment of chorea associated with Huntington’s disease.
Brand Names
- Rilutek
- Tiglutik
Indications
- amyotrophic lateral sclerosis (ALS)
- Huntington’s Disease (Huntington’s Chorea)
Side Effects
- abdominal pain
- amnesia
- anaphylactoid reactions
- anorexia
- arthralgia
- asthenia
- cough
- cystitis
- diarrhea
- dizziness
- drowsiness
- elevated hepatic enzymes
- flatulence
- headache
- hepatitis
- hypertension
- hypoesthesia
- insomnia
- interstitial lung disease
- nausea
- neutropenia
- pancreatitis
- paresthesias
- peripheral edema
- pneumonitis
- pruritus
- rhinitis
- sinus tachycardia
- vertigo
- vomiting
- xerostomia
Monitoring Parameters
- LFTs
- neurologic function
- serum bilirubin
Contraindications
- Asian patients
- breast-feeding
- hepatic disease
- pregnancy
Interactions
- Allopurinol
- Amiodarone
- Amlodipine; Atorvastatin
- Amoxicillin; Clarithromycin; Omeprazole
- Aspirin, ASA; Omeprazole
- Atorvastatin
- Atorvastatin; Ezetimibe
- Auranofin
- Azathioprine
- Barbiturates
- Busulfan
- Cannabidiol
- Carbamazepine
- Chlorpromazine
- Ciprofloxacin
- Dantrolene
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Dextromethorphan; Quinidine
- Diclofenac
- Diclofenac; Misoprostol
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Diphenhydramine; Ibuprofen
- Disulfiram
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Erythromycin
- Erythromycin; Sulfisoxazole
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Floxuridine
- Flutamide
- Fluvoxamine
- Fosphenytoin
- Green Tea
- Halothane
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Infliximab
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Interferon Beta-1a
- Interferon Beta-1b
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ketoconazole
- Leflunomide
- Lesinurad; Allopurinol
- Leuprolide; Norethindrone
- Levonorgestrel
- Lopinavir; Ritonavir
- Mercaptopurine, 6-MP
- Mestranol; Norethindrone
- Methotrexate
- Methoxsalen
- Methyldopa
- Mexiletine
- Minocycline
- Modafinil
- Nevirapine
- Niacin; Simvastatin
- Nitrofurantoin
- Norethindrone
- Norgestrel
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oral Contraceptives
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Peginterferon beta-1a
- Pexidartinib
- Phenytoin
- Propylthiouracil, PTU
- Pyrazinamide, PZA
- Quinidine
- Quinine
- Rifampin
- Ritonavir
- Rucaparib
- Segesterone Acetate; Ethinyl Estradiol
- Simvastatin
- Simvastatin; Sitagliptin
- St. John’s Wort, Hypericum perforatum
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulindac
- Tacrine
- Telithromycin
- Teriflunomide
- Testosterone
- Thiabendazole
- Thioguanine, 6-TG
- Ticlopidine
- Tipranavir
- tobacco
- Valproic Acid, Divalproex Sodium
- Vemurafenib
- Zafirlukast
- Zileuton
