Ribociclib

What is Ribociclib

Ribociclib is an oral, selective inhibitor of cyclin-dependent kinases (CDKs) 4 and 6, which are both involved in tumor cell progression during phase G1 to phase S in the cell cycle.

By inhibiting CDK 4 and 6, ribociclib prevents the deactivation of the tumor suppressor protein known as retinoblastoma susceptibility gene protein, and interferes with tumor cell progression.

Ribociclib is FDA-approved for the initial endocrine-based treatment of hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer in combination with an aromatase inhibitor in pre/peri/postmenopausal women, and in combination with fulvestrant for the treatment of postmenopausal women with HR-positive, HER2-negative advanced or metastatic breast cancer, either as initial endocrine based therapy or following disease progression on endocrine therapy.

Brand Name

KISQALI

Indications & Dosage

• breast cancer

For the treatment of breast cancer

for the first-line treatment of HR-positive, HER2-negative advanced or metastatic breast cancer as initial endocrine-based therapy, in combination with an aromatase inhibitor

Side Effects

1. abdominal pain
2. acute respiratory distress syndrome (ARDS)
3. alopecia
4. anemia
5. anorexia
6. arthralgia
7. asthenia
8. back pain
9. constipation
10. cough
11. diarrhea
12. dizziness
13. dysgeusia
14. dyspnea
15. elevated liver enzymes
16. erythema
17. fatigue
18. fever
19. headache
20. hyperbilirubinemia
21. hypocalcemia
22. hypoglycemia
23. hypokalemia
24. hypophosphatemia
25. infection
26. insomnia
27. interstitial lung disease
28. lacrimation
29. leukopenia
30. lymphopenia
31. nausea
32. neutropenia
33. peripheral edema
34. pneumonitis
35. pruritus
36. pulmonary fibrosis
37. QT prolongation
38. rash
39. renal failure (unspecified)
40. stomatitis
41. syncope
42. thrombocytopenia
43. vertigo
44. vomiting
45. xerophthalmia
46. xerosis
47. xerostomia

Monitoring Parameters

• CBC with differential
• ECG
• LFTs
• pregnancy testing
• serum electrolytes

Contraindications

• alcoholism
• bone marrow suppression
• bradycardia
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• chronic lung disease (CLD)
• contraception requirements
• coronary artery disease
• diabetes mellitus
• electrolyte imbalance
• females
• geriatric
• heart failure
• hepatic disease
• hepatotoxicity
• hypertension
• hypocalcemia
• hypokalemia
• hypomagnesemia
• infertility
• long QT syndrome
• malnutrition
• myocardial infarction
• neutropenia
• pneumonitis
• pregnancy
• pregnancy testing
• QT prolongation
• reproductive risk
• thyroid disease

Interactions

• Abacavir; Dolutegravir; Lamivudine
• Abemaciclib
• Acalabrutinib
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Codeine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Tramadol
• Aclidinium; Formoterol
• Ado-Trastuzumab emtansine
• Albuterol
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• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Almotriptan
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• Alprazolam
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• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
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• Amoxicillin; Clarithromycin; Lansoprazole
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