What is Ribociclib
Ribociclib is an oral, selective inhibitor of cyclin-dependent kinases (CDKs) 4 and 6, which are both involved in tumor cell progression during phase G1 to phase S in the cell cycle.
By inhibiting CDK 4 and 6, ribociclib prevents the deactivation of the tumor suppressor protein known as retinoblastoma susceptibility gene protein, and interferes with tumor cell progression.
Ribociclib is FDA-approved for the initial endocrine-based treatment of hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer in combination with an aromatase inhibitor in pre/peri/postmenopausal women, and in combination with fulvestrant for the treatment of postmenopausal women with HR-positive, HER2-negative advanced or metastatic breast cancer, either as initial endocrine based therapy or following disease progression on endocrine therapy.
Brand Name
KISQALI
Indications & Dosage
- breast cancer
For the treatment of breast cancer
for the first-line treatment of HR-positive, HER2-negative advanced or metastatic breast cancer as initial endocrine-based therapy, in combination with an aromatase inhibitor
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- alopecia
- anemia
- anorexia
- arthralgia
- asthenia
- back pain
- constipation
- cough
- diarrhea
- dizziness
- dysgeusia
- dyspnea
- elevated liver enzymes
- erythema
- fatigue
- fever
- headache
- hyperbilirubinemia
- hypocalcemia
- hypoglycemia
- hypokalemia
- hypophosphatemia
- infection
- insomnia
- interstitial lung disease
- lacrimation
- leukopenia
- lymphopenia
- nausea
- neutropenia
- peripheral edema
- pneumonitis
- pruritus
- pulmonary fibrosis
- QT prolongation
- rash
- renal failure (unspecified)
- stomatitis
- syncope
- thrombocytopenia
- vertigo
- vomiting
- xerophthalmia
- xerosis
- xerostomia
Monitoring Parameters
- CBC with differential
- ECG
- LFTs
- pregnancy testing
- serum electrolytes
Contraindications
- alcoholism
- bone marrow suppression
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- chronic lung disease (CLD)
- contraception requirements
- coronary artery disease
- diabetes mellitus
- electrolyte imbalance
- females
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- infertility
- long QT syndrome
- malnutrition
- myocardial infarction
- neutropenia
- pneumonitis
- pregnancy
- pregnancy testing
- QT prolongation
- reproductive risk
- thyroid disease
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Ado-Trastuzumab emtansine
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alosetron
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
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- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
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- Buprenorphine; Naloxone
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- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
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- Ethosuximide
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- Etravirine
- Everolimus
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- Ezogabine
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- Felodipine
- Fentanyl
- Fingolimod
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- Fosamprenavir
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- Fosphenytoin
- Fostamatinib
- Gefitinib
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyzine
- Ibrutinib
- Ibuprofen; Oxycodone
- Ibutilide
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Inotuzumab Ozogamicin
- Irinotecan
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- Isavuconazonium
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
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- Ixabepilone
- Ketoconazole
- Lapatinib
- Larotrectinib
- Lefamulin
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- Levalbuterol
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- Levomilnacipran
- Lidocaine
- Lithium
- Lofexidine
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macimorelin
- Macitentan
- Maprotiline
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Meperidine; Promethazine
- Mephobarbital
- Metaproterenol
- Metformin; Repaglinide
- Metformin; Saxagliptin
- Methadone
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- Midostaurin
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- Nimodipine
- Nisoldipine
- Norfloxacin
- Nortriptyline
- Octreotide
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- Olanzapine
- Olaparib
- Olodaterol
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- Omeprazole; Amoxicillin; Rifabutin
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- Osilodrostat
- Osimertinib
- Ospemifene
- Oxaliplatin
- Oxybutynin
- Oxycodone
- Ozanimod
- Paclitaxel
- Palbociclib
- Paliperidone
- Panobinostat
- Paricalcitol
- Pasireotide
- Pazopanib
- Pemigatinib
- Pentamidine
- Perindopril; Amlodipine
- Perphenazine
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- Pexidartinib
- Phenobarbital
- Phenylephrine; Promethazine
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