Ribociclib and Letrozole

What is Ribociclib and Letrozole combination medicine

Ribociclib is an oral, selective inhibitor of cyclin-dependent kinases (CDKs) 4 and 6, which are both involved in tumor cell progression during phase G1 to phase S in the cell cycle.

By inhibiting CDK 4 and 6, ribociclib prevents the deactivation of a tumor suppressor protein (retinoblastoma susceptibility gene protein) and interferes with tumor cell progression.

Letrozole is a non-steroidal oral aromatase inhibitor. Ribociclib and letrozole is indicated for the initial endocrine-based treatment of hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer in postmenopausal women.

Brand Name

KISQALI FEMARA

Indications

  • breast cancer

For the treatment of hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer

for the first-line treatment of HR-positive, HER2-negative advanced or metastatic breast cancer as initial endocrine-based therapy

Side Effects

  1. abdominal pain
  2. alopecia
  3. anemia
  4. anorexia
  5. arthralgia
  6. asthenia
  7. back pain
  8. bone fractures
  9. constipation
  10. cough
  11. diarrhea
  12. dyspepsia
  13. dyspnea
  14. elevated hepatic enzymes
  15. fatigue
  16. fever
  17. headache
  18. hyperbilirubinemia
  19. hypocalcemia
  20. hypoglycemia
  21. hypokalemia
  22. hypophosphatemia
  23. infection
  24. insomnia
  25. interstitial lung disease
  26. lacrimation
  27. leukopenia
  28. lymphopenia
  29. nausea
  30. neutropenia
  31. osteoporosis
  32. peripheral edema
  33. pneumonitis
  34. pruritus
  35. pulmonary fibrosis
  36. QT prolongation
  37. rash
  38. renal failure (unspecified)
  39. skin hypopigmentation
  40. stomatitis
  41. syncope
  42. thrombocytopenia
  43. vomiting
  44. xerophthalmia
  45. xerosis

Monitoring Parameters

  • CBC with differential
  • ECG
  • LFTs
  • pregnancy testing
  • serum electrolytes

Contraindications

  • alcoholism
  • bone marrow suppression
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • chronic lung disease (CLD)
  • contraception requirements
  • coronary artery disease
  • diabetes mellitus
  • electrolyte imbalance
  • females
  • geriatric
  • heart failure
  • hepatic disease
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • infants
  • infertility
  • long QT syndrome
  • malnutrition
  • myocardial infarction
  • neutropenia
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • QT prolongation
  • reproductive risk
  • thyroid disease

Interactions

  • Abacavir; Dolutegravir; Lamivudine
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  • Acalabrutinib
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
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