Pregabalin

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Pregabalin Brand Names- Lyrica | Lyrica CR

What is Pregabalin

Pregabalin is indicated for neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, postherpetic neuralgia, fibromyalgia, and adjunctive therapy for partial onset seizures.

Pregabalin is an oral compound that is chemically and structurally similar to gabapentin, with antiepileptic, analgesic, and anxiolytic properties.

Antiepileptic drugs, including pregabalin, are associated with an increased risk of suicidal thoughts and behaviors; patients should be monitored for new or worsening depression, suicidal thoughts and/or behaviors, and changes in mood or behavior.

Indications

  • diabetic neuropathy
  • fibromyalgia
  • generalized anxiety disorder (GAD)
  • neuropathic pain
  • partial seizures
  • postherpetic neuralgia
  • social phobia (social anxiety disorder)
  • spinal cord injury

NOTE: If pregabalin dose is reduced, discontinued, or substituted with an alternative medication, this should be done gradually over a minimum interval of 1 week.

For the symptomatic treatment of neuropathic pain

for pain associated with peripheral diabetic neuropathy (DPN)

Side Effects

  1. abdominal pain
  2. acute cerebellar syndrome
  3. agitation
  4. alopecia
  5. amblyopia
  6. amenorrhea
  7. amnesia
  8. anaphylactoid reactions
  9. anemia
  10. angioedema
  11. anxiety
  12. aphasia
  13. apnea
  14. appetite stimulation
  15. arthralgia
  16. ascites
  17. asthenia
  18. ataxia
  19. back pain
  20. blepharitis
  21. blurred vision
  22. breast enlargement
  23. bullous rash
  24. cervicitis
  25. chest pain (unspecified)
  26. chills
  27. cholecystitis
  28. cholelithiasis
  29. colitis
  30. coma
  31. confusion
  32. conjunctivitis
  33. constipation
  34. contact dermatitis
  35. cough
  36. crystalluria
  37. delirium
  38. depression
  39. diarrhea
  40. diplopia
  41. dizziness
  42. drowsiness
  43. dysarthria
  44. dysgeusia
  45. dyskinesia
  46. dysmenorrhea
  47. dyspareunia
  48. dysphagia
  49. dyspnea
  50. dystonic reaction
  51. dysuria
  52. ecchymosis
  53. edema
  54. ejaculation dysfunction
  55. elevated hepatic enzymes
  56. encephalopathy
  57. eosinophilia
  58. epididymitis
  59. esophageal ulceration
  60. esophagitis
  61. euphoria
  62. exfoliative dermatitis
  63. exophthalmos
  64. fatigue
  65. fever
  66. flatulence
  67. fluid retention
  68. gastritis
  69. GI bleeding
  70. glycosuria
  71. Guillain-Barre syndrome
  72. gynecomastia
  73. hallucinations
  74. headache
  75. heart failure
  76. hematuria
  77. hiccups
  78. hirsutism
  79. hostility
  80. hyperacusis
  81. hyperalgesia
  82. hyperesthesia
  83. hyperkinesis
  84. hypersalivation
  85. hypertension
  86. hypertonia
  87. hypoesthesia
  88. hypoglycemia
  89. hypotension
  90. hypotonia
  91. impotence (erectile dysfunction)
  92. increased intracranial pressure
  93. increased urinary frequency
  94. infection
  95. infertility
  96. insomnia
  97. iritis
  98. irritability
  99. keratitis
  100. keratoconjunctivitis
  101. laryngeal edema
  102. lethargy
  103. leukocytosis
  104. leukopenia
  105. leukorrhea
  106. libido decrease
  107. libido increase
  108. lymphadenopathy
  109. malaise
  110. mania
  111. melena
  112. memory impairment
  113. menorrhagia
  114. miosis
  115. muscle cramps
  116. myalgia
  117. myasthenia
  118. mydriasis
  119. myoclonia
  120. myopathy
  121. nausea
  122. neuritis
  123. new primary malignancy
  124. night blindness
  125. nystagmus
  126. ocular hemorrhage
  127. oliguria
  128. optic atrophy
  129. oral ulceration
  130. orgasm dysfunction
  131. orthostatic hypotension
  132. palpitations
  133. pancreatitis
  134. papilledema
  135. paranoia
  136. paresthesias
  137. parosmia
  138. pelvic pain
  139. peripheral edema
  140. peripheral neuropathy
  141. pharyngitis
  142. phlebitis
  143. photophobia
  144. photosensitivity
  145. physiological dependence
  146. polycythemia
  147. proteinuria
  148. pruritus
  149. psychomotor impairment
  150. psychosis
  151. ptosis
  152. pulmonary edema
  153. pulmonary fibrosis
  154. purpura
  155. rash
  156. renal failure (unspecified)
  157. respiratory depression
  158. retinal edema
  159. retroperitoneal fibrosis
  160. rhabdomyolysis
  161. sinus tachycardia
  162. sinusitis
  163. skin atrophy
  164. skin necrosis
  165. skin ulcer
  166. Stevens-Johnson syndrome
  167. stomatitis
  168. suicidal ideation
  169. syncope
  170. thrombocytopenia
  171. tinnitus
  172. torticollis
  173. tremor
  174. trismus
  175. urinary incontinence
  176. urinary retention
  177. urticaria
  178. uveitis
  179. ventricular fibrillation
  180. vertigo
  181. vesicular rash
  182. visual impairment
  183. vomiting
  184. weight gain
  185. wheezing
  186. withdrawal
  187. xerophthalmia
  188. xerosis
  189. xerostomia
  190. yawning

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • angioedema
  • breast-feeding
  • chronic obstructive pulmonary disease (COPD)
  • CNS depression
  • coadministration with other CNS depressants
  • depression
  • diabetes mellitus
  • driving or operating machinery
  • ethanol intoxication
  • geriatric
  • heart failure
  • labor
  • obstetric delivery
  • ocular disease
  • pregnancy
  • pulmonary disease
  • renal failure
  • renal impairment
  • reproductive risk
  • respiratory depression
  • substance abuse
  • suicidal ideation

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Alfentanil
  • Alogliptin; Pioglitazone
  • Alprazolam
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Benazepril
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Angiotensin-converting enzyme inhibitors
  • Apomorphine
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzphetamine
  • Brexpiprazole
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloral Hydrate
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Clemastine
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Dantrolene
  • Desipramine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Droperidol
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Esketamine
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Ezogabine
  • Fenfluramine
  • Fentanyl
  • Flibanserin
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gabapentin
  • General anesthetics
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanfacine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Imipramine
  • Isocarboxazid
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levodopa
  • Levorphanol
  • Lisdexamfetamine
  • Lisinopril
  • Lofexidine
  • Lorazepam
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Maprotiline
  • Meclizine
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Metformin; Pioglitazone
  • Metformin; Rosiglitazone
  • Methadone
  • Methamphetamine
  • Methocarbamol
  • Methohexital
  • Methyldopa
  • Metoclopramide
  • Midazolam
  • Mirtazapine
  • Moexipril
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Nortriptyline
  • Olanzapine
  • Orphenadrine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Pimavanserin
  • Pimozide
  • Pioglitazone
  • Pramipexole
  • Primidone
  • Prochlorperazine
  • Promethazine
  • Propoxyphene
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Quinapril
  • Ramelteon
  • Ramipril
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Ropinirole
  • Rosiglitazone
  • Rotigotine
  • Safinamide
  • Scopolamine
  • Secobarbital
  • Selegiline
  • Sodium Oxybate
  • Sufentanil
  • Suvorexant
  • Tapentadol
  • Tasimelteon
  • Temazepam
  • Tetrabenazine
  • Thalidomide
  • Thiazolidinediones
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tizanidine
  • Topiramate
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
  • Triprolidine
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Zaleplon
  • Ziprasidone
  • Zolpidem

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