Prednisone

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Prednisone Brand Names

Deltasone | Predone | RAYOS | Sterapred | Sterapred DS

What is Prednisone

Prednisone is the most commonly-prescribed oral corticosteroid. The drug is metabolized in the liver to its active form, prednisolone.

Relative to hydrocortisone, prednisone is roughly 4 times as potent as a glucocorticoid.

Prednisone is used in many conditions in adult and pediatric patients, including allograft rejection, asthma, chronic obstructive pulmonary disease (COPD), systemic lupus erythematosus (SLE), rheumatoid and psoriatic arthritis, and many other allergic, dermatologic, and inflammatory states.

Prednisone has very little mineralocorticoid activity, so it is not used in the management of adrenal insufficiency unless a more potent mineralocorticoid is administered concomitantly.

Systemic corticosteroids may be added to other long-term maintenance medications in the management of uncontrolled severe persistent asthma.

Once stabilization of asthma is achieved, regular attempts should be made to reduce or eliminate the use of systemic corticosteroids due to the side effects associated with chronic administration.

Short courses of treatment may be used in moderate to severe exacerbations of asthma.

Short courses of systemic corticosteroids such as prednisone have particular benefit in treating acute exacerbations of COPD.

If long-term therapy with prednisone is required for any indication, the lowest possible effective dose should be used.

Indications

  1. absence seizures
  2. ACE-inhibitor induced angioedema
  3. acute interstitial nephritis (AIN)
  4. acute lymphocytic leukemia (ALL)
  5. acute respiratory distress syndrome (ARDS)
  6. Addison’s disease
  7. adrenocortical insufficiency
  8. allergic conjunctivitis
  9. allergic rhinitis
  10. amyloidosis
  11. anaphylaxis
  12. angioedema
  13. ankylosing spondylitis
  14. anterior segment inflammation
  15. asthma
  16. atopic dermatitis
  17. autoimmune hepatitis
  18. Behcet’s syndrome
  19. Bell’s palsy
  20. berylliosis
  21. bursitis
  22. carpal tunnel syndrome
  23. chorioretinitis
  24. chronic lymphocytic leukemia (CLL)
  25. chronic obstructive pulmonary disease (COPD)
  26. Churg-Strauss syndrome
  27. congenital adrenal hyperplasia
  28. contact dermatitis
  29. corneal ulcer
  30. Crohn’s disease
  31. dermatitis
  32. dermatitis herpetiformis
  33. dermatomyositis
  34. Duchenne muscular dystrophy
  35. eczema
  36. endophthalmitis
  37. eosinophilic pneumonia
  38. epicondylitis
  39. erythema multiforme
  40. erythroblastopenia
  41. exfoliative dermatitis
  42. food allergy
  43. gouty arthritis
  44. graft-versus-host disease (GVHD)
  45. heart transplant rejection
  46. heart transplant rejection prophylaxis
  47. hemolytic anemia
  48. Hodgkin lymphoma
  49. hypercalcemia
  50. hypoplastic anemia
  51. immune thrombocytopenic purpura (ITP)
  52. infantile spasms
  53. iritis
  54. juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
  55. Kawasaki disease
  56. keratitis
  57. kidney transplant rejection prophylaxis
  58. Lennox-Gastaut syndrome
  59. Loeffler’s syndrome
  60. lupus nephritis
  61. mixed connective tissue disease
  62. multiple myeloma
  63. myasthenia gravis
  64. Mycobacterium avium complex infection
  65. mycosis fungoides
  66. myoclonic seizures
  67. nephrotic syndrome
  68. optic neuritis
  69. osteoarthritis
  70. pemphigus
  71. perennial allergies
  72. pericarditis
  73. peripheral T-cell lymphoma (PTCL)
  74. Pneumocystis pneumonia (PCP)
  75. pneumonitis
  76. polyarteritis nodosa
  77. polychondritis
  78. polymyalgia rheumatica
  79. polymyositis
  80. proteinuria
  81. psoriasis
  82. psoriatic arthritis
  83. pulmonary fibrosis
  84. rheumatic carditis
  85. rheumatoid arthritis
  86. sarcoidosis
  87. seasonal allergies
  88. seborrheic dermatitis
  89. serum sickness
  90. spinal cord compression
  91. Stevens-Johnson syndrome
  92. systemic anaplastic large-cell lymphoma
  93. systemic lupus erythematosus (SLE)
  94. temporal arteritis
  95. tenosynovitis
  96. thrombocytopenia
  97. thyroiditis
  98. toxoplasmosis
  99. tuberculosis infection
  100. ulcerative colitis
  101. urticaria
  102. uveitis
  103. vasculitis
  104. Wegener’s granulomatosis

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. acneiform rash
  4. adrenocortical insufficiency
  5. alopecia
  6. amenorrhea
  7. amnesia
  8. anaphylactoid reactions
  9. anemia
  10. angina
  11. angioedema
  12. anorexia
  13. anxiety
  14. appetite stimulation
  15. arrhythmia exacerbation
  16. arthralgia
  17. avascular necrosis
  18. blurred vision
  19. bone fractures
  20. bradycardia
  21. candidiasis
  22. cardiac arrest
  23. cardiomyopathy
  24. cataracts
  25. constipation
  26. Cushing’s syndrome
  27. delirium
  28. depression
  29. diabetes mellitus
  30. diaphoresis
  31. diarrhea
  32. dizziness
  33. dysmenorrhea
  34. ecchymosis
  35. edema
  36. EEG changes
  37. elevated hepatic enzymes
  38. emotional lability
  39. erythema
  40. esophageal ulceration
  41. euphoria
  42. exfoliative dermatitis
  43. exophthalmos
  44. fever
  45. fluid retention
  46. gastritis
  47. GI bleeding
  48. GI perforation
  49. glossitis
  50. glycosuria
  51. growth inhibition
  52. hallucinations
  53. headache
  54. heart failure
  55. hepatomegaly
  56. hiccups
  57. hirsutism
  58. hypercholesterolemia
  59. hyperglycemia
  60. hypernatremia
  61. hypertension
  62. hyperthyroidism
  63. hypocalcemia
  64. hypokalemia
  65. hypotension
  66. hypothalamic-pituitary-adrenal (HPA) suppression
  67. hypothyroidism
  68. immunosuppression
  69. impaired cognition
  70. impaired wound healing
  71. increased intracranial pressure
  72. infection
  73. insomnia
  74. irritability
  75. lethargy
  76. leukocytosis
  77. lupus-like symptoms
  78. malaise
  79. mania
  80. memory impairment
  81. menstrual irregularity
  82. metabolic alkalosis
  83. myalgia
  84. myocardial infarction
  85. myopathy
  86. nausea
  87. neuritis
  88. neutropenia
  89. ocular hypertension
  90. ocular infection
  91. optic neuritis
  92. osteopenia
  93. osteoporosis
  94. palpitations
  95. pancreatitis
  96. papilledema
  97. paresthesias
  98. peptic ulcer
  99. perineal pain
  100. peripheral neuropathy
  101. petechiae
  102. phlebitis
  103. physiological dependence
  104. postmenopausal bleeding
  105. pseudotumor cerebri
  106. psychosis
  107. pulmonary edema
  108. purpura
  109. rash
  110. restlessness
  111. retinopathy
  112. seizures
  113. sinus tachycardia
  114. skin atrophy
  115. skin hyperpigmentation
  116. skin hypopigmentation
  117. sodium retention
  118. striae
  119. stroke
  120. syncope
  121. telangiectasia
  122. tendon rupture
  123. thromboembolism
  124. thrombosis
  125. urticaria
  126. vasculitis
  127. vertigo
  128. visual impairment
  129. vomiting
  130. weakness
  131. weight gain
  132. weight loss
  133. withdrawal
  134. xerosis

Monitoring Parameters

  • blood glucose
  • blood pressure
  • growth rate
  • pulmonary function tests (PFTs)
  • serum potassium
  • weight

Contraindications

  • abrupt discontinuation
  • breast-feeding
  • cataracts
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • diverticulitis
  • fungal infection
  • geriatric
  • GI perforation
  • glaucoma
  • growth inhibition
  • heart failure
  • helminth infection
  • hepatic disease
  • herpes infection
  • hypertension
  • hyperthyroidism
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • hypothyroidism
  • immunosuppression
  • increased intracranial pressure
  • increased intraocular pressure
  • infection
  • measles
  • myasthenia gravis
  • myocardial infarction
  • neonates
  • neuromuscular disease
  • ocular infection
  • optic neuritis
  • osteopenia
  • osteoporosis
  • peptic ulcer disease
  • pregnancy
  • psychosis
  • renal disease
  • seizure disorder
  • surgery
  • thyroid disease
  • tuberculosis
  • ulcerative colitis
  • vaccination
  • varicella
  • viral infection

Interactions

  • Abatacept
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetazolamide
  • Acetohexamide
  • Adalimumab
  • Albiglutide
  • Aldesleukin, IL-2
  • Alefacept
  • Alemtuzumab
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
  • Alpha-glucosidase Inhibitors
  • Altretamine
  • Ambenonium Chloride
  • Amifampridine
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminolevulinic Acid
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amiodarone
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Aprepitant, Fosaprepitant
  • Argatroban
  • Arsenic Trioxide
  • Asparaginase Erwinia chrysanthemi
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol; Chlorthalidone
  • Atracurium
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azathioprine
  • Azilsartan; Chlorthalidone
  • Basiliximab
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bepridil
  • Bexarotene
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bivalirudin
  • Boceprevir
  • Bortezomib
  • Bosentan
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Bupropion
  • Bupropion; Naltrexone
  • Butabarbital
  • Cabozantinib
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Carmustine, BCNU
  • Carvedilol
  • Ceritinib
  • Certolizumab pegol
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorambucil
  • Chlorothiazide
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Cimetidine
  • Cisatracurium
  • Citalopram
  • Clindamycin
  • Clofarabine
  • Cobicistat
  • Codeine; Phenylephrine; Promethazine
  • Conivaptan
  • Daclatasvir
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Denileukin Diftitox
  • Denosumab
  • Desmopressin
  • Dextran
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Digoxin
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dofetilide
  • Doxacurium
  • Dronedarone
  • Droperidol
  • Dulaglutide
  • Echinacea
  • Econazole
  • Efalizumab
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Erlotinib
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Estramustine
  • Estrogens
  • Etravirine
  • Exenatide
  • Fluconazole
  • Fluoxymesterone
  • Fosamprenavir
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gallium Ga 68 Dotatate
  • Gemcitabine
  • Gentamicin
  • Glecaprevir; Pibrentasvir
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycerol Phenylbutyrate
  • Golimumab
  • Guaifenesin; Phenylephrine
  • Halofantrine
  • Haloperidol
  • Hemin
  • Heparin
  • Hetastarch
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Hydroxyurea
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Idelalisib
  • Imatinib
  • Incretin Mimetics
  • Indapamide
  • Inebilizumab
  • Infliximab
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isoproterenol
  • Isotretinoin
  • Itraconazole
  • Ixabepilone
  • Ketoconazole
  • L-Asparaginase Escherichia coli
  • Ledipasvir; Sofosbuvir
  • Letermovir
  • Levetiracetam
  • Levomethadyl
  • Linagliptin; Metformin
  • Liraglutide
  • Live Vaccines
  • Lixisenatide
  • Lomustine, CCNU
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Macimorelin
  • Magnesium Salicylate
  • Mannitol
  • Mecasermin rinfabate
  • Mecasermin, Recombinant, rh-IGF-1
  • Meglitinides
  • Melphalan
  • Mepenzolate
  • Mephobarbital
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methacholine
  • Methazolamide
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methoxsalen
  • Methyclothiazide
  • Metolazone
  • Metyrapone
  • Micafungin
  • Mifepristone
  • Mitotane
  • Mitoxantrone
  • Mivacurium
  • Moxifloxacin
  • Muromonab-CD3
  • Natalizumab
  • Nateglinide
  • Nelarabine
  • Neostigmine
  • Neuromuscular blockers
  • Nevirapine
  • Nicardipine
  • Nonsteroidal antiinflammatory drugs
  • Ocrelizumab
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Ondansetron
  • Oritavancin
  • Oxymetholone
  • Ozanimod
  • Pancuronium
  • Pazopanib
  • Pegaspargase
  • Peginterferon Alfa-2a
  • Penicillamine
  • Phenobarbital
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Photosensitizing agents (topical)
  • Physostigmine
  • Pimozide
  • Posaconazole
  • Potassium
  • Potassium Chloride
  • Potassium Phosphate; Sodium Phosphate
  • Potassium-sparing diuretics
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Primidone
  • Propranolol
  • Propylthiouracil, PTU
  • Purine analogs
  • Pyridostigmine
  • Quetiapine
  • Quinolones
  • Rapacuronium
  • Regular Insulin
  • Repaglinide
  • Rifabutin
  • Rifampin
  • Rifamycins
  • Rifapentine
  • Rilonacept
  • Ritodrine
  • Ritonavir
  • Rituximab
  • Rituximab; Hyaluronidase
  • Rocuronium
  • Salicylates
  • Salsalate
  • Sapropterin
  • Saquinavir
  • Sargramostim, GM-CSF
  • Semaglutide
  • SGLT2 Inhibitors
  • Simeprevir
  • Siponimod
  • Sipuleucel-T
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium Chloride
  • Sodium Iodide
  • Sodium Phenylbutyrate
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Somatropin, rh-GH
  • Succinylcholine
  • Sulfonylureas
  • Telaprevir
  • Telbivudine
  • Telithromycin
  • Telotristat Ethyl
  • Tesamorelin
  • Testosterone
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thyroid hormones
  • Tobramycin
  • Tolazamide
  • Tolbutamide
  • Tositumomab
  • Trandolapril; Verapamil
  • Tranexamic Acid
  • Tretinoin, ATRA
  • Tuberculin Purified Protein Derivative, PPD
  • Tubocurarine
  • Tucatinib
  • Vancomycin
  • Vecuronium
  • Vemurafenib
  • Verapamil
  • Vigabatrin
  • Vincristine Liposomal
  • Voriconazole
  • Vorinostat
  • Warfarin
  • Zafirlukast
  • Zileuton

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