Potassium Phosphate and Sodium Phosphate

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Potassium Phosphate and Sodium Phosphate Brand Names

Av-Phos | K-Phos Neutral | Neutra-Phos | Phos-NaK | Uro-Kp-Neutral | Virt-Phos 250 Neutral

What is Potassium Phosphate and Sodium Phosphate

Potassium phosphate and sodium phosphate is a phosphorus supplement that increases urinary phosphate and pyrophosphate, and can be used in the dietary management of hypophosphatemia.

As a phosphorus supplement, the tablet formulations supply 25% of the US Recommended Daily Allowance (US RDA) of phosphorus, per tablet, for adults and children > 4 years of age.

Patients requiring potassium or sodium restriction may not be good candidates for this formulation, as each tablet yields approximately 298 mg of sodium (13 mEq) and 45 mg of potassium (1.1 mEq). When treatment is initiated, some patients experience a mild laxative effect.

This usually resolves after the first few days but could persist to an unpleasant degree, requiring a dose reduction until the effect subsides or potentially discontinuation.

Additionally, patients who have kidney stones may pass old stones upon initiation of phosphate therapy. Such patients should be warned of this possibility.

Indications

  • hypophosphatemia
  • nutritional supplementation

For the dietary management of hypophosphatemia, to increases urinary phosphate and pyrophosphate, or for phosphorus nutritional supplementation

Side Effects

  1. abdominal pain
  2. bone pain
  3. confusion
  4. diarrhea
  5. dizziness
  6. headache
  7. muscle cramps
  8. nausea
  9. nephrolithiasis
  10. neuropathic pain
  11. osteomalacia
  12. polydipsia
  13. seizures
  14. vomiting
  15. weakness
  16. weight gain

Contraindications

  • adrenal insufficiency
  • breast-feeding
  • burns
  • cardiac disease
  • dehydration
  • heart failure
  • hepatic disease
  • hypernatremia
  • hyperphosphatemia
  • hypertension
  • hypoparathyroidism
  • infection
  • nephrolithiasis
  • osteomalacia
  • pancreatitis
  • peripheral edema
  • preeclampsia
  • pregnancy
  • pulmonary edema
  • renal disease
  • renal failure
  • renal impairment
  • sodium restriction

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Alendronate; Cholecalciferol
  • Aliskiren; Valsartan
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Benazepril
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Antacids
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Azelastine; Fluticasone
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Beclomethasone
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Betamethasone
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Budesonide
  • Budesonide; Formoterol
  • Budesonide; Glycopyrrolate; Formoterol
  • Burosumab
  • Caffeine
  • Calcium
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium; Vitamin D
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Choline Salicylate; Magnesium Salicylate
  • Ciclesonide
  • Colchicine
  • Colchicine; Probenecid
  • Colestipol
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Deflazacort
  • Dexamethasone
  • Diazoxide
  • Dichlorphenamide
  • Diflunisal
  • Digoxin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eplerenone
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Erdafitinib
  • Ergocalciferol, Vitamin D2
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • food
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Heparin
  • Hetastarch; Dextrose; Electrolytes
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocortisone
  • Irbesartan
  • Iron
  • Lisinopril
  • Losartan
  • Magnesium
  • Magnesium Hydroxide
  • Magnesium Salicylate
  • Magnesium Salts
  • Methadone
  • Methyldopa
  • Methylprednisolone
  • Moexipril
  • Mometasone
  • Nebivolol; Valsartan
  • Olmesartan
  • Penicillin G
  • Perindopril
  • Perindopril; Amlodipine
  • Potassium-sparing diuretics
  • Prednisolone
  • Prednisone
  • Quinapril
  • Ramipril
  • Sacubitril; Valsartan
  • Salsalate
  • Sevelamer
  • Spironolactone
  • Sucralfate
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Tacrolimus
  • Telmisartan
  • Trandolapril
  • Trandolapril; Verapamil
  • Triamcinolone
  • Triamterene
  • Trientine
  • Trimethoprim
  • Valsartan
  • Vitamin D
  • Vitamin D analogs
  • Zinc
  • Zinc Salts

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