Methenamine Sodium Acid Phosphate Brand Names- Uroqid Acid No-2 | Utac | Visqid A/A
What is Methenamine Sodium Acid Phosphate
Methenamine sodium acid phosphate are used together in an oral preparation for suppression or elimination of bacteriuria associated with chronic and recurrent urinary tract infections.
Methenamine mandelate is an antiinfective agent. Sodium acid phosphate is used to acidify the urine. An acidic urine is required to hydrolyze methenamine to ammonia and formaldehyde, which produces the bactericidal activity.
These products have been available on the market since before 1962, which is when Congress passed the amended Federal Food, Drug, and Cosmetic Act requiring that the FDA establish both safety and efficacy for all subsequently approved drugs.
Thus, these products are unapproved marketed drugs that have not been formally evaluated by the FDA for clinical safety and efficacy.
Indications
- Enterococcus sp.
- Escherichia coli
- Klebsiella aerogenes
- Micrococcus pyogenes
- Proteus vulgaris
- Pseudomonas aeruginosa
- Staphylococcus sp.
- urinary tract infection (UTI)
- urinary tract infection (UTI) prophylaxis
Side Effects
- abdominal pain
- bone pain
- confusion
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- dysuria
- fatigue
- headache
- hematuria
- muscle cramps
- nausea
- oliguria
- osteomalacia
- palpitations
- peripheral edema
- polydipsia
- rash
- seizures
- sinus tachycardia
- vomiting
- weakness
- weight gain
Monitoring Parameters
- serum creatinine/BUN
- urinalysis
Contraindications
- anuria
- breast-feeding
- children
- dehydration
- eclampsia
- edema
- heart failure
- hepatic disease
- hypernatremia
- hyperphosphatemia
- hypertension
- hypoparathyroidism
- infants
- neonates
- oliguria
- pancreatitis
- peripheral edema
- pregnancy
- pulmonary edema
- renal failure
- renal impairment
- sodium restriction
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetazolamide
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alkalinizing Agents
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amphetamine; Dextroamphetamine Salts
- Antacids
- Ascorbic Acid, Vitamin C
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol; Chlorthalidone
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Beclomethasone
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzphetamine
- Betamethasone
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Budesonide
- Budesonide; Formoterol
- Caffeine
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Chlorothiazide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Ciclesonide
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Colchicine
- Colchicine; Probenecid
- Corticosteroids
- Cortisone
- Deflazacort
- Dexamethasone
- Diazoxide
- Dichlorphenamide
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan; Hydrochlorothiazide, HCTZ
- Erdafitinib
- Erythromycin; Sulfisoxazole
- Fludrocortisone
- Flunisolide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- food
- Formoterol; Mometasone
- Fosinopril; Hydrochlorothiazide, HCTZ
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocortisone
- Lisdexamfetamine
- Magnesium Hydroxide
- Magnesium Salicylate
- Methadone
- Methamphetamine
- Methazolamide
- Methyclothiazide
- Methyldopa
- Methylprednisolone
- Metolazone
- Mometasone
- Phentermine; Topiramate
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Prednisolone
- Prednisone
- Pyrimethamine; Sulfadoxine
- Salsalate
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Thiazide diuretics
- Topiramate
- Triamcinolone
- Trientine
