Sodium Phosphate Monobasic Monohydrate and Sodium Phosphate Dibasic Anhydrous

What is Sodium Phosphate Monobasic Monohydrate and Sodium Phosphate Dibasic Anhydrous

Sodium phosphate monobasic monohydrate; sodium phosphate dibasic anhydrous is a combination of sodium phosphate salts used as a laxative for the relief of constipation and as a purgative to evacuate the bowel prior to colonic radiologic examinations or surgery.

Brand Names

  • Fleet
  • OsmoPrep
  • Ready To Use Saline
  • Visicol

Indications & Dosage

  • bowel preparation
  • constipation
  • hypophosphatemia
  • nutritional supplementation

For use as a bowel evacuant to clean the colon prior to colonoscopy (bowel preparation)

Side Effects

  1. abdominal pain
  2. acute phosphate nephropathy
  3. aluminum toxicity
  4. anaphylactoid reactions
  5. angioedema
  6. arrhythmia exacerbation
  7. bowel ischemia
  8. bronchospasm
  9. colitis
  10. dehydration
  11. diarrhea
  12. dizziness
  13. dysphagia
  14. dyspnea
  15. edema
  16. fecal incontinence
  17. fecal urgency
  18. fluid retention
  19. headache
  20. hypernatremia
  21. hyperphosphatemia
  22. hypocalcemia
  23. hypokalemia
  24. hypotension
  25. hypovolemia
  26. injection site reaction
  27. metabolic acidosis
  28. muscle cramps
  29. muscle paralysis
  30. nausea
  31. oral ulceration
  32. paresthesias
  33. peptic ulcer
  34. phlebitis
  35. pruritus
  36. QT prolongation
  37. rash
  38. renal failure (unspecified)
  39. seizures
  40. tetany
  41. urticaria
  42. vomiting
  43. weakness

Monitoring Parameters

  • ECG
  • serum creatinine/BUN
  • serum electrolytes
  • serum phosphate

Contraindications

  • abdominal pain
  • acute abdomen
  • acute myocardial infarction
  • alcoholism
  • angina
  • appendicitis
  • arrhythmia exacerbation
  • ascites
  • biliary cirrhosis
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • colitis
  • coronary artery bypass graft surgery (CABG)
  • dehydration
  • edema
  • electrolyte imbalance
  • esophageal stricture
  • gastroparesis
  • geriatric
  • GI bleeding
  • GI obstruction
  • GI perforation
  • heart failure
  • hepatic disease
  • hepatitis
  • hypernatremia
  • hyperphosphatemia
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hyponatremia
  • hypoparathyroidism
  • hypothyroidism
  • hypovolemia
  • ileus
  • infants
  • inflammatory bowel disease
  • neonates
  • nephrotoxicity
  • osteomalacia
  • pancreatitis
  • peripheral edema
  • pregnancy
  • premature neonates
  • pulmonary edema
  • QT prolongation
  • renal disease
  • renal failure
  • renal impairment
  • scleroderma
  • seizure disorder
  • seizures
  • sodium restriction
  • surgery
  • toxic megacolon
  • ulcerative colitis
  • vomiting

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Antacids
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Azelastine; Fluticasone
  • Beclomethasone
  • Betamethasone
  • Bisacodyl
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Budesonide
  • Budesonide; Formoterol
  • Bulk-forming laxative
  • Burosumab
  • Caffeine
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Carbonic anhydrase inhibitors
  • Choline Salicylate; Magnesium Salicylate
  • Chromium
  • Ciclesonide
  • Colchicine
  • Colchicine; Probenecid
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Deflazacort
  • Dexamethasone
  • Diazoxide
  • Dichlorphenamide
  • Erdafitinib
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Hetastarch; Dextrose; Electrolytes
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrocortisone
  • Indapamide
  • Lactulose
  • Loop diuretics
  • Lubiprostone
  • Magnesium Citrate
  • Magnesium Hydroxide
  • Magnesium Salicylate
  • Methadone
  • Methyldopa
  • Methylprednisolone
  • Mineral Oil
  • Mometasone
  • Nonsteroidal antiinflammatory drugs
  • Pimozide
  • Polyethylene Glycol
  • Polyethylene Glycol; Electrolytes
  • Polyethylene Glycol; Electrolytes; Ascorbic Acid
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Potassium-sparing diuretics
  • Prednisolone
  • Prednisone
  • Salsalate
  • Spironolactone
  • Stool Softners
  • Thiazide diuretics
  • Triamcinolone
  • Triamterene
  • Trientine
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