Potassium Phosphate

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Potassium Phosphate Brand Name– K-Phos

What is Potassium Phosphate

Potassium phosphate is a supplement used intravenously to treat hypophosphatemia or prevent hypophosphatemia in patients receiving parenteral nutrition (PN).

Guidelines generally recommend the use of potassium phosphate for potassium serum concentration less than 4 mg/dL and sodium phosphate for potassium serum concentration more than 4 mg/dL.

Potassium phosphate is also used orally in adults for urinary acidification and to augment the efficacy of methenamine therapy in treating urinary tract infections.

Phosphorus is an important element in all body tissues.

Phosphorus is the principal ion in the bone and cartilage; phosphate is the primary ion in extra- and intracellular fluid, cell membranes, nucleic acids, and energy mediators and exists in the body as inorganic phosphate or phosphate esters.

Phosphorus serves many functions in the body including carbohydrate metabolism, energy transfer, and muscle contraction.

Phosphorus is present in nearly all foods, and if a deficiency state is present, it is usually induced (e.g., diabetic acidosis treatment, excessive antacid use, long-term PN).

The concomitant potassium content must be taken into consideration when replacing phosphorus, and particular caution should be used in patients with cardiac disease, renal impairment, adrenal insufficiency, or other conditions with a risk of hyperkalemia

Indications

  • hypophosphatemia
  • nutritional supplementation
  • urinary acidification
  • 1 mmol of phosphorus weighs 31 mg.
  • Potassium phosphate injection contains 3 mmol of phosphorus per mL equivalent to 4.4 mEq of potassium per mL.
  • Potassium phosphate tablets contain 114 mg of phosphorus (3.7 mmol) and 144 mg of potassium (3.7 mEq) in each 500 mg tablet.

Adverse ReactionsSide EffectsAdverse Reactions

  1. abdominal pain
  2. aluminum toxicity
  3. arthralgia
  4. AV block
  5. bone pain
  6. cardiac arrest
  7. confusion
  8. diarrhea
  9. dyspnea
  10. hyperkalemia
  11. hyperphosphatemia
  12. hypertension
  13. hypocalcemia
  14. hypotension
  15. injection site reaction
  16. muscle cramps
  17. muscle paralysis
  18. nausea
  19. osteomalacia
  20. paresthesias
  21. phlebitis
  22. seizures
  23. tetany
  24. tremor
  25. vomiting
  26. weakness

Monitoring Parameters

  • serum calcium
  • serum creatinine/BUN
  • serum phosphate
  • serum potassium

Contraindications

  • adrenal insufficiency
  • breast-feeding
  • burns
  • cardiac disease
  • dehydration
  • hyperkalemia
  • hyperphosphatemia
  • hypocalcemia
  • hypoparathyroidism
  • muscle channelopathy
  • nephrolithiasis
  • osteomalacia
  • pancreatitis
  • pregnancy
  • renal failure
  • renal impairment

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Alendronate; Cholecalciferol
  • Aliskiren; Valsartan
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Benazepril
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Burosumab
  • Calcium
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium; Vitamin D
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Colestipol
  • Cyclosporine
  • Diflunisal
  • Digoxin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eplerenone
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Erdafitinib
  • Ergocalciferol, Vitamin D2
  • food
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Heparin
  • Hetastarch; Dextrose; Electrolytes
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Irbesartan
  • Iron
  • Lisinopril
  • Losartan
  • Magnesium
  • Magnesium Hydroxide
  • Magnesium Salts
  • Moexipril
  • Nebivolol; Valsartan
  • Olmesartan
  • Penicillin G
  • Perindopril
  • Perindopril; Amlodipine
  • Potassium-sparing diuretics
  • Quinapril
  • Ramipril
  • Sacubitril; Valsartan
  • Sevelamer
  • Spironolactone
  • Sucralfate
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Tacrolimus
  • Telmisartan
  • Trandolapril
  • Trandolapril; Verapamil
  • Triamterene
  • Trientine
  • Trimethoprim
  • Valsartan
  • Vitamin D
  • Vitamin D analogs
  • Zinc
  • Zinc Salts

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