Penicillin V (phenoxymethyl penicillin)

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Penicillin V Brand Name– Beepen VK | Veetids

What is Penicillin V

Penicillin V (phenoxymethyl penicillin) is a naturally derived antibiotic. It is preferred over penicillin G when oral administration is desired due to better gastric acid stability, which causes higher plasma levels.

Although penicillin V is more bioavailable than penicillin G, amoxicillin is now preferred in some clinical situations such as endocarditis prophylaxis.

Penicillin V was approved by the FDA in 1956.

Indications

  1. Actinomyces israelii
  2. actinomycosis
  3. anthrax
  4. anthrax prophylaxis
  5. Bacillus anthracis
  6. bacterial colonization eradication
  7. Borrelia burgdorferi
  8. Clostridium sp.
  9. Corynebacterium diphtheriae
  10. endocarditis prophylaxis
  11. erysipelas
  12. Leptospira sp.
  13. Listeria monocytogenes
  14. necrotizing ulcerative gingivitis
  15. Neisseria gonorrhoeae
  16. otitis media
  17. Pasteurella multocida
  18. penicillin desensitization
  19. pharyngitis
  20. pneumococcal prophylaxis
  21. rat-bite fever
  22. rheumatic fever prophylaxis
  23. scarlet fever
  24. skin and skin structure infections
  25. Spirillum minus
  26. Staphylococcus sp.
  27. Streptobacillus moniliformis
  28. Streptococcus dysgalactiae
  29. Streptococcus pneumoniae
  30. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  31. Treponema pallidum
  32. Viridans streptococci

Side Effects

  1. acute generalized exanthematous pustulosis (AGEP)
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. anemia
  5. angioedema
  6. bullous rash
  7. contact dermatitis
  8. diarrhea
  9. dysphagia
  10. eosinophilia
  11. esophageal ulceration
  12. esophagitis
  13. exfoliative dermatitis
  14. fever
  15. hemolytic anemia
  16. interstitial nephritis
  17. laryngeal edema
  18. leukopenia
  19. maculopapular rash
  20. nausea
  21. nephrotic syndrome
  22. odynophagia
  23. peripheral neuropathy
  24. pruritus
  25. pseudomembranous colitis
  26. rash
  27. serum sickness
  28. Stevens-Johnson syndrome
  29. superinfection
  30. thrombocytopenia
  31. tongue discoloration
  32. toxic epidermal necrolysis
  33. urticaria
  34. vasculitis
  35. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • asthma
  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • children
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • neonates
  • penicillin hypersensitivity
  • phenylketonuria
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • ulcerative colitis
  • viral infection

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Choline Salicylate; Magnesium Salicylate
  • Colchicine; Probenecid
  • Dichlorphenamide
  • Dienogest; Estradiol valerate
  • Digoxin
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Erythromycin; Sulfisoxazole
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethacrynic Acid
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Furosemide
  • Indomethacin
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Magnesium Salicylate
  • Mestranol; Norethindrone
  • Methotrexate
  • Neomycin
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Probenecid
  • Pyrimethamine; Sulfadoxine
  • Salsalate
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfisoxazole
  • Sulfonamides
  • Tetracyclines
  • Typhoid Vaccine
  • Warfarin

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