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Penicillin G Benzathine Brand Names- Bicillin L-A | Permapen
What is Penicillin G Benzathine
Penicillin G benzathine for parenteral use is the salt of the naturally derived antibiotic, Penicillium chrysogenum. Benzathine penicillin is a repository formulation for intramuscular use only; after injection a depot forms in the tissue, from which the drug is hydrolyzed at the intramuscular injection site to penicillin G and slowly released into the blood stream over several days.
This provides much lower, but prolonged, serum concentrations compared to aqueous penicillin G.
These characteristics increase patient compliance but limit therapeutic indications.
Many organisms may be susceptible to penicillin G. Penicillin G benzathine is recommended for the treatment of mild to moderate infections, prophylaxis and treatment of rheumatic fever, and the management of syphilis.
Penicillins were initially discovered in 1928 and first used clinically in 1941.
Penicillin G was approved by the FDA in 1943.
Indications
- Actinomyces israelii
- Bacillus anthracis
- bacterial colonization eradication
- bejel
- Borrelia burgdorferi
- Clostridium sp.
- Corynebacterium diphtheriae
- diphtheria prophylaxis
- Erysipelothrix rhusiopathiae
- Fusobacterium sp.
- Haemophilus sp.
- Leptospira sp.
- Listeria monocytogenes
- Neisseria gonorrhoeae
- Neisseria meningitidis
- neurosyphilis
- Pasteurella multocida
- Peptostreptococcus sp.
- pharyngitis
- pinta
- Prevotella melaninogenica
- rheumatic fever prophylaxis
- Salmonella sp.
- Shigella sp.
- Spirillum minus
- Staphylococcus sp.
- Streptobacillus moniliformis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus bovis
- Streptococcus dysgalactiae
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp.
- Streptococcus sp. (Group C)
- Streptococcus sp. (Group G)
- Streptococcus sp. (Group H)
- Streptococcus sp. (Group L)
- Streptococcus sp. (Group M)
- syphilis
- Treponema carateum
- Treponema pallidum
- upper respiratory tract infections
- Viridans streptococci
- yaws
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anxiety
- apnea
- arthralgia
- asthenia
- bleeding
- blurred vision
- bowel necrosis
- cardiac arrest
- chills
- coma
- confusion
- cyanosis
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dyspnea
- ecchymosis
- edema
- elevated hepatic enzymes
- eosinophilia
- euphoria
- exfoliative dermatitis
- fatigue
- fever
- hallucinations
- headache
- hematuria
- hemolytic anemia
- hypotension
- hypoxia
- impotence (erectile dysfunction)
- injection site reaction
- Jarisch-Herxheimer reaction
- laryngeal edema
- leukopenia
- lymphadenopathy
- maculopapular rash
- myelitis
- myoglobinuria
- nausea
- palpitations
- peripheral neuropathy
- priapism
- proteinuria
- pruritus
- pseudomembranous colitis
- psychosis
- pulmonary embolism
- renal failure (unspecified)
- rhabdomyolysis
- seizures
- serum sickness
- sinus tachycardia
- skin atrophy
- skin ulcer
- Stevens-Johnson syndrome
- superinfection
- syncope
- thrombocytopenia
- tinnitus
- tongue discoloration
- toxic epidermal necrolysis
- tremor
- urticaria
- vasculitis
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- asthma
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- colitis
- diarrhea
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- intravenous administration
- neonates
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- ulcerative colitis
- viral infection
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Colchicine; Probenecid
- Colestipol
- Dichlorphenamide
- Dienogest; Estradiol valerate
- Digoxin
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Erythromycin; Sulfisoxazole
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethacrynic Acid
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Furosemide
- Indomethacin
- Leflunomide
- Leuprolide; Norethindrone
- Levonorgestrel
- Magnesium Salicylate
- Mestranol; Norethindrone
- Methotrexate
- Nitisinone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Probenecid
- Pyrimethamine; Sulfadoxine
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Benzoate; Sodium Phenylacetate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Teriflunomide
- Tetracyclines
- Typhoid Vaccine
- Warfarin