Penicillin G Benzathine

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Penicillin G Benzathine Brand Names- Bicillin L-A | Permapen

What is Penicillin G Benzathine

Penicillin G benzathine for parenteral use is the salt of the naturally derived antibiotic, Penicillium chrysogenum. Benzathine penicillin is a repository formulation for intramuscular use only; after injection a depot forms in the tissue, from which the drug is hydrolyzed at the intramuscular injection site to penicillin G and slowly released into the blood stream over several days.

This provides much lower, but prolonged, serum concentrations compared to aqueous penicillin G.

These characteristics increase patient compliance but limit therapeutic indications.

Many organisms may be susceptible to penicillin G. Penicillin G benzathine is recommended for the treatment of mild to moderate infections, prophylaxis and treatment of rheumatic fever, and the management of syphilis.

Penicillins were initially discovered in 1928 and first used clinically in 1941.

Penicillin G was approved by the FDA in 1943.

Indications

  1. Actinomyces israelii
  2. Bacillus anthracis
  3. bacterial colonization eradication
  4. bejel
  5. Borrelia burgdorferi
  6. Clostridium sp.
  7. Corynebacterium diphtheriae
  8. diphtheria prophylaxis
  9. Erysipelothrix rhusiopathiae
  10. Fusobacterium sp.
  11. Haemophilus sp.
  12. Leptospira sp.
  13. Listeria monocytogenes
  14. Neisseria gonorrhoeae
  15. Neisseria meningitidis
  16. neurosyphilis
  17. Pasteurella multocida
  18. Peptostreptococcus sp.
  19. pharyngitis
  20. pinta
  21. Prevotella melaninogenica
  22. rheumatic fever prophylaxis
  23. Salmonella sp.
  24. Shigella sp.
  25. Spirillum minus
  26. Staphylococcus sp.
  27. Streptobacillus moniliformis
  28. Streptococcus agalactiae (group B streptococci)
  29. Streptococcus bovis
  30. Streptococcus dysgalactiae
  31. Streptococcus pneumoniae
  32. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  33. Streptococcus sp.
  34. Streptococcus sp. (Group C)
  35. Streptococcus sp. (Group G)
  36. Streptococcus sp. (Group H)
  37. Streptococcus sp. (Group L)
  38. Streptococcus sp. (Group M)
  39. syphilis
  40. Treponema carateum
  41. Treponema pallidum
  42. upper respiratory tract infections
  43. Viridans streptococci
  44. yaws

Side Effects

  1. acute generalized exanthematous pustulosis (AGEP)
  2. agitation
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. angioedema
  6. anxiety
  7. apnea
  8. arthralgia
  9. asthenia
  10. bleeding
  11. blurred vision
  12. bowel necrosis
  13. cardiac arrest
  14. chills
  15. coma
  16. confusion
  17. cyanosis
  18. diaphoresis
  19. diarrhea
  20. dizziness
  21. drowsiness
  22. dyspnea
  23. ecchymosis
  24. edema
  25. elevated hepatic enzymes
  26. eosinophilia
  27. euphoria
  28. exfoliative dermatitis
  29. fatigue
  30. fever
  31. hallucinations
  32. headache
  33. hematuria
  34. hemolytic anemia
  35. hypotension
  36. hypoxia
  37. impotence (erectile dysfunction)
  38. injection site reaction
  39. Jarisch-Herxheimer reaction
  40. laryngeal edema
  41. leukopenia
  42. lymphadenopathy
  43. maculopapular rash
  44. myelitis
  45. myoglobinuria
  46. nausea
  47. palpitations
  48. peripheral neuropathy
  49. priapism
  50. proteinuria
  51. pruritus
  52. pseudomembranous colitis
  53. psychosis
  54. pulmonary embolism
  55. renal failure (unspecified)
  56. rhabdomyolysis
  57. seizures
  58. serum sickness
  59. sinus tachycardia
  60. skin atrophy
  61. skin ulcer
  62. Stevens-Johnson syndrome
  63. superinfection
  64. syncope
  65. thrombocytopenia
  66. tinnitus
  67. tongue discoloration
  68. toxic epidermal necrolysis
  69. tremor
  70. urticaria
  71. vasculitis
  72. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • asthma
  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • intravenous administration
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • ulcerative colitis
  • viral infection

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Colchicine; Probenecid
  • Colestipol
  • Dichlorphenamide
  • Dienogest; Estradiol valerate
  • Digoxin
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Erythromycin; Sulfisoxazole
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethacrynic Acid
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Furosemide
  • Indomethacin
  • Leflunomide
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Magnesium Salicylate
  • Mestranol; Norethindrone
  • Methotrexate
  • Nitisinone
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Probenecid
  • Pyrimethamine; Sulfadoxine
  • Salsalate
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfisoxazole
  • Sulfonamides
  • Teriflunomide
  • Tetracyclines
  • Typhoid Vaccine
  • Warfarin

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