Penicillin G Procaine

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Penicillin G Procaine Brand Name– Wycillin

What is Penicillin G Procaine

Penicillin G Procaine is an equimolar compound of procaine and penicillin G antibiotic for intramuscular use.

It provides a tissue depot from which a plateau type of blood level is achieved that lasts over several hours.

Procaine penicillin is indicated for the treatment of moderately severe infections due to penicillin G susceptible organisms that are susceptible to the low and persistent serum levels achieved with this formulation.

Penicillins were initially discovered in 1928 and first used clinically in 1941.

Penicillin G was approved by the FDA in 1943.

Indications

  1. Actinomyces sp.
  2. anthrax prophylaxis
  3. Bacillus anthracis
  4. bejel
  5. Clostridium sp.
  6. Corynebacterium diphtheriae
  7. diphtheria
  8. endocarditis
  9. erysipelas
  10. Erysipelothrix rhusiopathiae
  11. Leptospira sp.
  12. Listeria monocytogenes
  13. necrotizing ulcerative gingivitis
  14. Neisseria meningitidis
  15. neurosyphilis
  16. pinta
  17. pneumonia
  18. rat-bite fever
  19. scarlet fever
  20. skin and skin structure infections
  21. Spirillum minus
  22. Staphylococcus sp.
  23. Streptobacillus moniliformis
  24. Streptococcus pneumoniae
  25. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  26. syphilis
  27. tonsillitis
  28. Treponema carateum
  29. Treponema pallidum
  30. upper respiratory tract infections
  31. yaws

Side Effects

  1. acute generalized exanthematous pustulosis (AGEP)
  2. agitation
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. angioedema
  6. anxiety
  7. arthralgia
  8. chills
  9. confusion
  10. depression
  11. diarrhea
  12. edema
  13. elevated hepatic enzymes
  14. exfoliative dermatitis
  15. fever
  16. hallucinations
  17. hemolytic anemia
  18. injection site reaction
  19. Jarisch-Herxheimer reaction
  20. leukopenia
  21. maculopapular rash
  22. methemoglobinemia
  23. nausea
  24. pseudomembranous colitis
  25. rash
  26. seizures
  27. serum sickness
  28. Stevens-Johnson syndrome
  29. superinfection
  30. thrombocytopenia
  31. tongue discoloration
  32. toxic epidermal necrolysis
  33. urticaria
  34. vomiting
  35. weakness

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • asthma
  • breast-feeding
  • carbapenem hypersensitivity
  • cardiac disease
  • cephalosporin hypersensitivity
  • colitis
  • diarrhea
  • G6PD deficiency
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • intravenous administration
  • methemoglobinemia
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • pulmonary disease
  • renal failure
  • renal impairment
  • ulcerative colitis
  • viral infection

Interactions

  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amyl Nitrite
  • Articaine; Epinephrine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzhydrocodone; Acetaminophen
  • Benzocaine
  • Benzocaine; Butamben; Tetracaine
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Chloroquine
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Colchicine; Probenecid
  • Colestipol
  • Cyclophosphamide
  • Dapsone
  • Dichlorphenamide
  • Dienogest; Estradiol valerate
  • Digoxin
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Erythromycin; Sulfisoxazole
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethacrynic Acid
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Flutamide
  • Fosphenytoin
  • Furosemide
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydroxyurea
  • Ifosfamide
  • Indomethacin
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Leflunomide
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Lidocaine
  • Lidocaine; Prilocaine
  • Magnesium Salicylate
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Mestranol; Norethindrone
  • Methotrexate
  • Metoclopramide
  • Nitisinone
  • Nitrates
  • Nitrofurantoin
  • Nitroglycerin
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Phenobarbital
  • Phenytoin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primaquine
  • Primidone
  • Probenecid
  • Pyrimethamine; Sulfadoxine
  • Quinine
  • Rasburicase
  • Ropivacaine
  • Salsalate
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfisoxazole
  • Sulfonamides
  • Teriflunomide
  • Tetracaine
  • Tetracyclines
  • Typhoid Vaccine
  • Valproic Acid, Divalproex Sodium
  • Warfarin

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