Penicillin G Benzathine Penicillin G Procaine

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Penicillin G Benzathine Penicillin G Procaine Brand Name– Bicillin C R

What is Penicillin G Benzathine Penicillin G Procaine

Penicillin G Benzathine Penicillin G Procaine is a combination of two long-acting forms of Penicillin G.

Penicillin G Benzathine Penicillin G Procaine is for intramuscular use only.

After injection of this combination product, a depot forms in the tissue, from which the two forms of penicillin are hydrolyzed at the intramuscular injection site to penicillin G, and then slowly released into the blood stream over several days.

This provides lower, though prolonged, serum concentrations of penicillin compared to aqueous penicillin G.

These characteristics can increase patient compliance, but limit the therapeutic uses.

Penicillin G Benzathine Penicillin G Procaine is approved for use in moderately severe streptococcal and pneumococcal infections, and should not be used for the treatment of sexually transmitted infections such as syphilis.

Penicillins were initially discovered in 1928 and first used clinically in 1941.

Penicillin G was approved by the FDA in 1943.

Indications

  1. Actinomyces israelii
  2. Bacillus anthracis
  3. Clostridium sp.
  4. Corynebacterium diphtheriae
  5. erysipelas
  6. Leptospira sp.
  7. Listeria monocytogenes
  8. Neisseria gonorrhoeae
  9. otitis media
  10. pneumonia
  11. scarlet fever
  12. skin and skin structure infections
  13. Staphylococcus sp.
  14. Streptobacillus moniliformis
  15. Streptococcus agalactiae (group B streptococci)
  16. Streptococcus bovis
  17. Streptococcus dysgalactiae
  18. Streptococcus pneumoniae
  19. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  20. Streptococcus sp.
  21. Treponema pallidum
  22. upper respiratory tract infections
  23. Viridans streptococci

Side Effects

  1. acute generalized exanthematous pustulosis (AGEP)
  2. agitation
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. angioedema
  6. anxiety
  7. apnea
  8. asthenia
  9. bleeding
  10. blurred vision
  11. bowel necrosis
  12. cardiac arrest
  13. chills
  14. coma
  15. confusion
  16. cyanosis
  17. diaphoresis
  18. diarrhea
  19. dizziness
  20. drowsiness
  21. dyspnea
  22. edema
  23. elevated hepatic enzymes
  24. eosinophilia
  25. euphoria
  26. exfoliative dermatitis
  27. fatigue
  28. fever
  29. hallucinations
  30. headache
  31. hematuria
  32. hemolytic anemia
  33. hypotension
  34. hypoxia
  35. impotence (erectile dysfunction)
  36. injection site reaction
  37. laryngeal edema
  38. leukopenia
  39. lymphadenopathy
  40. maculopapular rash
  41. methemoglobinemia
  42. myelitis
  43. myoglobinuria
  44. nausea
  45. pallor
  46. palpitations
  47. peripheral vasodilation
  48. priapism
  49. proteinuria
  50. pruritus
  51. pseudomembranous colitis
  52. psychosis
  53. pulmonary embolism
  54. pulmonary hypertension
  55. rash
  56. renal failure (unspecified)
  57. rhabdomyolysis
  58. seizures
  59. serum sickness
  60. sinus tachycardia
  61. skin atrophy
  62. skin ulcer
  63. Stevens-Johnson syndrome
  64. superinfection
  65. syncope
  66. thrombocytopenia
  67. tinnitus
  68. tissue necrosis
  69. tongue discoloration
  70. toxic epidermal necrolysis
  71. urticaria
  72. vasculitis
  73. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • asthma
  • breast-feeding
  • carbapenem hypersensitivity
  • cardiac disease
  • cephalosporin hypersensitivity
  • colitis
  • diarrhea
  • ester local anesthetic hypersensitivity
  • G6PD deficiency
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • intravenous administration
  • methemoglobinemia
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • pulmonary disease
  • renal failure
  • renal impairment
  • syphilis
  • ulcerative colitis
  • viral infection

Interactions

  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amyl Nitrite
  • Articaine; Epinephrine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzhydrocodone; Acetaminophen
  • Benzocaine
  • Benzocaine; Butamben; Tetracaine
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Chloroquine
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Colchicine; Probenecid
  • Colestipol
  • Cyclophosphamide
  • Dapsone
  • Dichlorphenamide
  • Dienogest; Estradiol valerate
  • Digoxin
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Erythromycin; Sulfisoxazole
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethacrynic Acid
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Flutamide
  • Fosphenytoin
  • Furosemide
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydroxyurea
  • Ifosfamide
  • Indomethacin
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Leflunomide
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Lidocaine
  • Lidocaine; Prilocaine
  • Magnesium Salicylate
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Mestranol; Norethindrone
  • Methotrexate
  • Metoclopramide
  • Nitisinone
  • Nitrates
  • Nitrofurantoin
  • Nitroglycerin
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Phenobarbital
  • Phenytoin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primaquine
  • Primidone
  • Probenecid
  • Pyrimethamine; Sulfadoxine
  • Quinine
  • Rasburicase
  • Ropivacaine
  • Salsalate
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfisoxazole
  • Sulfonamides
  • Teriflunomide
  • Tetracaine
  • Tetracyclines
  • Typhoid Vaccine
  • Valproic Acid, Divalproex Sodium
  • Warfarin

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