Peginterferon Alfa 2b

Peginterferon Alfa 2b Brand Names- PegIntron | SYLATRON

What is Peginterferon Alfa 2b

Peginterferon alfa 2b is a covalent conjugate of recombinant interferon alfa-2b with monomethoxy polyethylene glycol (PEG).

It is indicated for the treatment of chronic hepatitis C virus infections and for the adjuvant treatment of melanoma with microscopic or gross nodal involvement within 84 days of definitive surgical resection including complete lymphadenectomy.

Interferon alfa 2b represents one specific subtype of alpha interferon (i.e., interferon alpha-2). It differs from interferon alfa 2a by only one amino acid at position 23. ‘Pegylated’ interferon alfa 2b results in a molecule with a longer half-life than traditional interferon alfa 2b.

The longer duration of action prevents viral replication between doses. Peginterferon alfa 2b has significantly higher sustained virologic response rates than interferon alfa-2b.

Peginterferon alfa 2b and regular interferon alfa 2b cause similar adverse reactions; however, peginterferon is more likely to result in mild bone marrow depression.

Use of peginterferon alfa 2b with ribavirin or with ribavirin and a direct-acting antiviral (DAA) is recommended for the treatment of chronic hepatitis C; the treatment goal is the attainment of a sustained virologic response, which is defined as the achievement of undetectable HCV RNA at the end of treatment and 24 weeks later.

Indications

  1. adenovirus
  2. encephalomyocarditis virus
  3. hepatitis B infection
  4. hepatitis B virus
  5. hepatitis C infection
  6. hepatitis C virus
  7. hepatitis D virus
  8. herpes simplex virus type 1
  9. herpes simplex virus type 2
  10. human immunodeficiency virus (HIV)
  11. human papillomavirus (HPV)
  12. human T-lymphotropic virus type I (HTLV-I)
  13. malignant melanoma
  14. poliovirus
  15. rhinovirus
  16. varicella-zoster virus
  17. variola virus (smallpox)
  18. vesicular stomatitis virus

Side Effects

  1. abdominal pain
  2. agitation
  3. alopecia
  4. anaphylactic shock
  5. anaphylactoid reactions
  6. anemia
  7. angina
  8. angioedema
  9. anorexia
  10. antibody formation
  11. anxiety
  12. aplastic anemia
  13. arthralgia
  14. asthenia
  15. autoimmune disease
  16. blurred vision
  17. bronchiolitis obliterans
  18. bundle-branch block
  19. cardiomyopathy
  20. chest pain (unspecified)
  21. chills
  22. colitis
  23. coma
  24. confusion
  25. conjunctivitis
  26. constipation
  27. cough
  28. cranial nerve palsies
  29. dehydration
  30. depression
  31. diabetes mellitus
  32. diabetic ketoacidosis
  33. diaphoresis
  34. diarrhea
  35. dizziness
  36. dysgeusia
  37. dyspepsia
  38. dyspnea
  39. elevated hepatic enzymes
  40. emotional lability
  41. encephalopathy
  42. erythema multiforme
  43. exfoliative dermatitis
  44. fatigue
  45. fever
  46. flushing
  47. GI bleeding
  48. growth inhibition
  49. hallucinations
  50. headache
  51. hearing loss
  52. hepatic failure
  53. hepatitis
  54. hepatomegaly
  55. hyperbilirubinemia
  56. hyperglycemia
  57. hypertension
  58. hyperthyroidism
  59. hypertriglyceridemia
  60. hypotension
  61. hypothyroidism
  62. impaired cognition
  63. infection
  64. injection site reaction
  65. insomnia
  66. interstitial nephritis
  67. irritability
  68. leukopenia
  69. lupus-like symptoms
  70. macular edema
  71. malaise
  72. mania
  73. memory impairment
  74. menstrual irregularity
  75. migraine
  76. musculoskeletal pain
  77. myalgia
  78. myocardial infarction
  79. nausea
  80. neutropenia
  81. optic neuritis
  82. palpitations
  83. pancreatitis
  84. papilledema
  85. paresthesias
  86. pericardial effusion
  87. pericarditis
  88. peripheral neuropathy
  89. pharyngitis
  90. photosensitivity
  91. pleural effusion
  92. pneumonitis
  93. proteinuria
  94. pruritus
  95. psoriasis
  96. psychosis
  97. pulmonary fibrosis
  98. pulmonary hypertension
  99. rash
  100. red cell aplasia
  101. renal failure (unspecified)
  102. retinal detachment
  103. retinal hemorrhage
  104. retinal thrombosis
  105. retinopathy
  106. rhabdomyolysis
  107. rhinitis
  108. seizures
  109. sinus tachycardia
  110. sinusitis
  111. Stevens-Johnson syndrome
  112. stomatitis
  113. stroke
  114. suicidal ideation
  115. supraventricular tachycardia (SVT)
  116. thrombocytopenia
  117. thrombotic thrombocytopenic purpura (TTP)
  118. tongue discoloration
  119. toxic epidermal necrolysis
  120. urticaria
  121. vasculitis
  122. ventricular tachycardia
  123. vertigo
  124. visual impairment
  125. vomiting
  126. weight loss
  127. xerosis
  128. xerostomia

Monitoring Parameters

  • CBC with differential
  • chest x-ray
  • ECG
  • hemoglobin/hematocrit
  • LFTs
  • ophthalmologic exam
  • plasma hepatitis C RNA
  • pregnancy testing
  • serum bilirubin
  • serum uric acid
  • thyroid function tests (TFTs)

Contraindications

  • alcoholism
  • anemia
  • angina
  • aplastic anemia
  • autoimmune disease
  • bipolar disorder
  • bleeding
  • bone marrow suppression
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • colitis
  • contraception requirements
  • coronary artery disease
  • dental disease
  • dental work
  • depression
  • diabetes mellitus
  • diabetic retinopathy
  • dialysis
  • driving or operating machinery
  • E. coli protein hypersensitivity
  • encephalopathy
  • ethanol ingestion
  • geriatric
  • Graves’ disease
  • growth inhibition
  • hepatic decompensation
  • hepatic disease
  • hepatitis
  • hepatitis B exacerbation
  • hepatitis C and HIV coinfection
  • human immunodeficiency virus (HIV) infection
  • hyperglycemia
  • hypertension
  • hyperthyroidism
  • hypertriglyceridemia
  • hypoglycemia
  • hypothyroidism
  • immune thrombocytopenic purpura (ITP)
  • infants
  • infection
  • infertility
  • ischemic colitis
  • jaundice
  • mania
  • myocardial infarction
  • neonates
  • neurologic events
  • neutropenia
  • ocular disease
  • optic neuritis
  • organ transplant
  • pancreatitis
  • papilledema
  • peripheral neuropathy
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • psoriasis
  • psychiatric event
  • psychosis
  • pulmonary disease
  • pulmonary hypertension
  • renal failure
  • renal impairment
  • reproductive risk
  • respiratory insufficiency
  • retinal bleeding
  • retinal detachment
  • rheumatoid arthritis
  • sarcoidosis
  • seizure disorder
  • seizures
  • serious hypersensitivity reactions or anaphylaxis
  • serious rash
  • sickle cell disease
  • stroke
  • substance abuse
  • suicidal ideation
  • systemic lupus erythematosus (SLE)
  • thalassemia
  • thrombocytopenia
  • thrombotic thrombocytopenic purpura (TTP)
  • thyroid disease
  • ulcerative colitis
  • use with ribavirin
  • vaccination
  • visual disturbance

Interactions

  • Abacavir
  • Abacavir; Dolutegravir; Lamivudine
  • Abacavir; Lamivudine, 3TC
  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alosetron
  • Alteplase
  • Altretamine
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amprenavir
  • Anagrelide
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Aripiprazole
  • Arsenic Trioxide
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Azathioprine
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Basiliximab
  • Bendamustine
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Brexpiprazole
  • Brimonidine; Timolol
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bupivacaine; Lidocaine
  • Caffeine
  • Caffeine; Ergotamine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carvedilol
  • Cevimeline
  • Chloroquine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Cinacalcet
  • Clomipramine
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Cyclosporine
  • Darifenacin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Desipramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dolasetron
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Dorzolamide; Timolol
  • Doxepin
  • Doxorubicin
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Efalizumab
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Encainide
  • Entecavir
  • Estramustine
  • Ethanol
  • Filgrastim, G-CSF
  • Flecainide
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flutamide
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluvoxamine
  • Folate analogs
  • Fosamprenavir
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxyurea
  • Ibritumomab Tiuxetan
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Imatinib
  • Imipramine
  • Indinavir
  • Influenza Virus Vaccine
  • Intranasal Influenza Vaccine
  • Lamivudine, 3TC
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lidocaine
  • Lidocaine; Prilocaine
  • Live Vaccines
  • Lomustine, CCNU
  • Lopinavir; Ritonavir
  • Maprotiline
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Meclizine
  • Melatonin
  • Melphalan
  • Meperidine; Promethazine
  • Methadone
  • Methamphetamine
  • Methotrexate
  • Methoxsalen
  • Metoclopramide
  • Mexiletine
  • Mirtazapine
  • Mitoxantrone
  • Natural Antineoplastics
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Nortriptyline
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oxycodone
  • Palonosetron
  • Paroxetine
  • Pegfilgrastim
  • Pemetrexed
  • Pentamidine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Pexidartinib
  • Phenylephrine; Promethazine
  • Pirfenidone
  • Pralatrexate
  • Promethazine
  • Propafenone
  • Propoxyphene
  • Propranolol
  • Protease inhibitors
  • Protriptyline
  • Purine analogs
  • Quinine
  • Ranolazine
  • Rasagiline
  • Reteplase, r-PA
  • Rilpivirine
  • Riluzole
  • Ritonavir
  • Ropinirole
  • Ropivacaine
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Saquinavir
  • Sertraline
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Stavudine, d4T
  • Streptokinase
  • Tamsulosin
  • Tbo-Filgrastim
  • Telbivudine
  • Tenecteplase
  • Terbinafine
  • Tetrabenazine
  • Theophylline, Aminophylline
  • Thioridazine
  • Thrombolytic Agents
  • Timolol
  • Tipranavir
  • Tizanidine
  • Tolterodine
  • Tositumomab
  • Tramadol
  • Tretinoin, ATRA
  • Triamterene
  • Trimipramine
  • Typhoid Vaccine
  • Umeclidinium
  • Umeclidinium; Vilanterol
  • Urokinase
  • Varicella-Zoster Virus Vaccine, Live
  • Venlafaxine
  • Vigabatrin
  • Warfarin
  • Yellow Fever Vaccine, Live
  • Yohimbine
  • Zalcitabine, ddC
  • Zidovudine, ZDV
  • Zileuton
  • Zolmitriptan
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