Peginterferon beta 1a

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Peginterferon beta 1a Brand Name– PLEGRIDY

What is Peginterferon beta 1a

Peginterferon beta 1a is available through recombinant DNA technology.

The drug is an amino acid glycoprotein that is covalently conjugated with a methoxy polyethylene glycol (PEG) molecule, which reduces clearance in vivo allowing for a more flexible dosing schedule when compared to interferon beta-1a products.

Peginterferon beta 1a is indicated for the treatment of adults with relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.

Peginterferon beta 1a is administered subcutaneously every 14 days, compared to weekly or three times weekly dosage regimens with interferon beta-1a products.

Peginterferon beta-1a like other interferon beta-1a treatments, produces a significant relative reduction of annualized MS relapse rates and disability progression.

Early treatment of MS with proper therapy may delay cognitive and physical disability. The interferon beta medications are generally considered the initial treatment options for pediatric patients with MS.

Monitor closely for side effects; hepatic injury has been observed with use.

Indications

  • multiple sclerosis

For the treatment of relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease

Side Effects

  1. anaphylactoid reactions
  2. angioedema
  3. antibody formation
  4. arthralgia
  5. asthenia
  6. cardiomyopathy
  7. chills
  8. depression
  9. elevated hepatic enzymes
  10. fever
  11. headache
  12. heart failure
  13. hemolytic-uremic syndrome
  14. hepatic failure
  15. hepatitis
  16. hyperbilirubinemia
  17. hyperthermia
  18. hyperthyroidism
  19. hypothyroidism
  20. injection site reaction
  21. leukopenia
  22. menorrhagia
  23. menstrual irregularity
  24. myalgia
  25. nausea
  26. neutropenia
  27. pancytopenia
  28. pruritus
  29. psychosis
  30. seizures
  31. suicidal ideation
  32. thrombocytopenia
  33. thrombotic microangiopathy
  34. thrombotic thrombocytopenic purpura (TTP)
  35. tissue necrosis
  36. urticaria
  37. vomiting

Monitoring Parameters

  • CBC with differential
  • LFTs
  • platelet count

Contraindications

  • alcoholism
  • angina
  • autoimmune disease
  • bone marrow suppression
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • depression
  • heart failure
  • hemolytic-uremic syndrome
  • hepatic disease
  • hepatitis
  • jaundice
  • myocardial infarction
  • pregnancy
  • psychosis
  • seizure disorder
  • suicidal ideation
  • thrombotic thrombocytopenic purpura (TTP)
  • thyroid disease

Peginterferon beta-1a is contraindicated for use in patients with a history of hypersensitivity to natural or recombinant interferon beta or peginterferon.

Interactions

  • Abacavir
  • Abacavir; Dolutegravir; Lamivudine
  • Abacavir; Lamivudine, 3TC
  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Amprenavir
  • Atazanavir
  • Atazanavir; Cobicistat
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Chloroquine
  • Clozapine
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Entecavir
  • Ethanol
  • Fosamprenavir
  • Indinavir
  • Lamivudine, 3TC
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lopinavir; Ritonavir
  • Nelfinavir
  • Nevirapine
  • Ocrelizumab
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ozanimod
  • Pexidartinib
  • Protease inhibitors
  • Rilpivirine
  • Riluzole
  • Ritonavir
  • Saquinavir
  • Stavudine, d4T
  • Telbivudine
  • Tipranavir
  • Vigabatrin
  • Zalcitabine, ddC
  • Zidovudine, ZDV

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