Peginterferon Alfa 2a

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Peginterferon Alfa 2a Brand Names

Pegasys | Pegasys ProClick

What is Peginterferon Alfa 2a

Peginterferon alfa 2a is approved for the treatment of chronic hepatitis C virus (HCV) infections in patients 5 years and older, and for the treatment of chronic hepatitis B virus (HBV) infections in patients 3 years and older.

The drug is a highly purified protein containing 165 amino acids (recombinant interferon alfa-2a) that is covalently conjugated with bis-monomethoxy polyethylene glycol (PEG).

Interferon alfa 2a represents only one specific subtype of alpha interferon (i.e., interferon alpha-2) and is produced by recombinant DNA technology that uses a genetically engineered Escherichia coli bacterium containing DNA that codes for the protein.

By increasing the size of the molecule with PEG (average molecular weight of 60,000 daltons), the absorption and half-life are prolonged, and the clearance is decreased.

The safety of peginterferon alfa 2a is comparable to interferon alfa-2a; however, the tolerability is increased.

Indications

  1. adenovirus
  2. encephalomyocarditis virus
  3. hepatitis B infection
  4. hepatitis B virus
  5. hepatitis C infection
  6. hepatitis C virus
  7. hepatitis D virus
  8. herpes simplex virus type 1
  9. herpes simplex virus type 2
  10. human immunodeficiency virus (HIV)
  11. human papillomavirus (HPV)
  12. human T-lymphotropic virus type I (HTLV-I)
  13. poliovirus
  14. rhinovirus
  15. varicella-zoster virus
  16. variola virus (smallpox)
  17. vesicular stomatitis virus

Side Effects

  1. abdominal pain
  2. alopecia
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. anemia
  6. anemia
  7. angina
  8. angioedema
  9. anorexia
  10. antibody formation
  11. anxiety
  12. aplastic anemia
  13. arthralgia
  14. asthenia
  15. autoimmune disease
  16. back pain
  17. blurred vision
  18. bronchiolitis obliterans
  19. bronchospasm
  20. bullous rash
  21. chest pain (unspecified)
  22. cholangitis
  23. colitis
  24. coma
  25. corneal erosion
  26. cough
  27. dehydration
  28. depression
  29. diabetes mellitus
  30. diaphoresis
  31. diarrhea
  32. dizziness
  33. dyspepsia
  34. dyspnea
  35. eczema vaccinatum
  36. elevated hepatic enzymes
  37. emotional lability
  38. epistaxis
  39. erythema multiforme
  40. exfoliative dermatitis
  41. fatigue
  42. fever
  43. GI bleeding
  44. hallucinations
  45. headache
  46. hearing loss
  47. hepatic failure
  48. hyperbilirubinemia
  49. hyperglycemia
  50. hypertension
  51. hyperthyroidism
  52. hypertriglyceridemia
  53. hypoglycemia
  54. hypothyroidism
  55. impaired cognition
  56. infection
  57. influenza
  58. injection site reaction
  59. insomnia
  60. interstitial nephritis
  61. irritability
  62. lupus-like symptoms
  63. lymphopenia
  64. macular edema
  65. memory impairment
  66. myalgia
  67. myocardial infarction
  68. nausea
  69. neutropenia
  70. neutropenia
  71. optic neuritis
  72. pancreatitis
  73. pancytopenia
  74. papilledema
  75. peptic ulcer
  76. peripheral neuropathy
  77. pharyngitis
  78. pneumonitis
  79. pruritus
  80. psoriasis
  81. psychosis
  82. pulmonary embolism
  83. pulmonary hypertension
  84. rash
  85. red cell aplasia
  86. retinal detachment
  87. retinal hemorrhage
  88. retinal thrombosis
  89. retinopathy
  90. seizures
  91. steatosis
  92. Stevens-Johnson syndrome
  93. stroke
  94. suicidal ideation
  95. thrombocytopenia
  96. thrombotic thrombocytopenic purpura (TTP)
  97. tongue discoloration
  98. urticaria
  99. vesicular rash
  100. visual impairment
  101. vomiting
  102. weight loss
  103. xerosis
  104. xerostomia

Monitoring Parameters

  • CBC with differential
  • chest x-ray
  • ECG
  • hemoglobin/hematocrit
  • LFTs
  • ophthalmologic exam
  • plasma hepatitis C RNA
  • pregnancy testing
  • serum creatinine/BUN
  • serum uric acid
  • thyroid function tests (TFTs)

Contraindications

  • alcoholism
  • anemia
  • angina
  • aplastic anemia
  • autoimmune disease
  • benzyl alcohol hypersensitivity
  • bipolar disorder
  • bleeding
  • bone marrow suppression
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • colitis
  • contraception requirements
  • coronary artery disease
  • dental disease
  • dental work
  • depression
  • diabetes mellitus
  • diabetic retinopathy
  • dialysis
  • driving or operating machinery
  • E. coli protein hypersensitivity
  • encephalopathy
  • ethanol ingestion
  • geriatric
  • Graves’ disease
  • growth inhibition
  • hepatic decompensation
  • hepatic disease
  • hepatitis
  • hepatitis B exacerbation
  • hepatitis C and HIV coinfection
  • human immunodeficiency virus (HIV) infection
  • hyperglycemia
  • hypertension
  • hyperthyroidism
  • hypertriglyceridemia
  • hypoglycemia
  • hypothyroidism
  • immune thrombocytopenic purpura (ITP)
  • infants
  • infection
  • infertility
  • ischemic colitis
  • jaundice
  • mania
  • menstrual irregularity
  • myocardial infarction
  • neonates
  • neurologic events
  • neutropenia
  • ocular disease
  • optic neuritis
  • organ transplant
  • pancreatitis
  • papilledema
  • peripheral neuropathy
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • psoriasis
  • psychiatric event
  • psychosis
  • pulmonary disease
  • pulmonary hypertension
  • renal failure
  • renal impairment
  • respiratory insufficiency
  • retinal bleeding
  • retinal detachment
  • rheumatoid arthritis
  • sarcoidosis
  • seizure disorder
  • seizures
  • serious hypersensitivity reactions or anaphylaxis
  • serious rash
  • sickle cell disease
  • stroke
  • substance abuse
  • suicidal ideation
  • systemic lupus erythematosus (SLE)
  • thalassemia
  • thrombocytopenia
  • thrombotic thrombocytopenic purpura (TTP)
  • thyroid disease
  • ulcerative colitis
  • use with ribavirin
  • vaccination
  • visual disturbance

Interactions

  • Abacavir
  • Abacavir; Dolutegravir; Lamivudine
  • Abacavir; Lamivudine, 3TC
  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alteplase
  • Altretamine
  • Amprenavir
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Arsenic Trioxide
  • Atazanavir
  • Atazanavir; Cobicistat
  • Azathioprine
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Basiliximab
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Chloroquine
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dexamethasone
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Efalizumab
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Entecavir
  • Estramustine
  • Ethanol
  • Filgrastim, G-CSF
  • Folate analogs
  • Fosamprenavir
  • Hydroxyurea
  • Ibritumomab Tiuxetan
  • Imatinib
  • Indinavir
  • Influenza Virus Vaccine
  • Intranasal Influenza Vaccine
  • Lamivudine, 3TC
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Live Vaccines
  • Lomustine, CCNU
  • Lopinavir; Ritonavir
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Melphalan
  • Methadone
  • Methotrexate
  • Methoxsalen
  • Methylprednisolone
  • Mitoxantrone
  • Natural Antineoplastics
  • Nelfinavir
  • Nevirapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Pegfilgrastim
  • Pemetrexed
  • Pexidartinib
  • Pralatrexate
  • Prednisolone
  • Prednisone
  • Protease inhibitors
  • Purine analogs
  • Reteplase, r-PA
  • Rilpivirine
  • Riluzole
  • Ritonavir
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Saquinavir
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Stavudine, d4T
  • Streptokinase
  • Tbo-Filgrastim
  • Telbivudine
  • Tenecteplase
  • Theophylline, Aminophylline
  • Thrombolytic Agents
  • Tipranavir
  • Tositumomab
  • Tretinoin, ATRA
  • Typhoid Vaccine
  • Urokinase
  • Varicella-Zoster Virus Vaccine, Live
  • Vigabatrin
  • Yellow Fever Vaccine, Live
  • Zalcitabine, ddC
  • Zidovudine, ZDV

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