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Metaxalone Brand Names- Metaxall | Skelaxin
What is Metaxalone
Metaxalone is an oral CNS depressant used as adjunct therapy for acute, painful musculoskeletal conditions.
Although the drug is classified as a skeletal muscle relaxant, it does not directly relax skeletal muscle.
Most of the beneficial effects of metaxalone are thought to be due to its sedative properties.
Metaxalone does not effectively treat skeletal muscle hyperactivity secondary to chronic neurologic disorders (e.g., cerebral palsy).
Metaxalone was FDA-approved in 1962.
Indications
- musculoskeletal pain
For the treatment of musculoskeletal pain associated with acute, painful musculoskeletal conditions, as an adjunct to rest, physical therapy, and other measures
Side Effects
- anaphylactoid reactions
- anxiety
- dizziness
- drowsiness
- dyspepsia
- headache
- hemolytic anemia
- irritability
- jaundice
- leukopenia
- nausea
- pruritus
- rash
- serotonin syndrome
- vomiting
Monitoring Parameters
- LFTs
- serum creatinine/BUN
Contraindications
- anemia
- breast-feeding
- coadministration with other CNS depressants
- driving or operating machinery
- ethanol ingestion
- geriatric
- hemolytic anemia
- hepatic disease
- hyperglycemia
- laboratory test interference
- pregnancy
- renal disease
- renal failure
- renal impairment
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Alprazolam
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Anxiolytics; Sedatives; and Hypnotics
- Apomorphine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Bacitracin
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Botulinum Toxins
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Cannabidiol
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloral Hydrate
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clemastine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclizine
- Cyproheptadine
- Desipramine
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Entacapone
- Esketamine
- Estazolam
- Eszopiclone
- Ethanol
- Fenfluramine
- Fentanyl
- Flurazepam
- food
- Gabapentin
- General anesthetics
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Imipramine
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levorphanol
- Lofexidine
- Lorazepam
- Loxapine
- Lumateperone
- Maprotiline
- Meclizine
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Methadone
- Methohexital
- Methscopolamine
- Midazolam
- Mirtazapine
- Molindone
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nortriptyline
- Oxazepam
- Oxycodone
- Oxymorphone
- Ozanimod
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenothiazines
- Pregabalin
- Primidone
- Protriptyline
- Quazepam
- Remifentanil
- Secobarbital
- Sedating H1-blockers
- Sodium Oxybate
- Sufentanil
- Tapentadol
- Temazepam
- Thalidomide
- Thiopental
- Thiothixene
- Tolcapone
- Tramadol
- Trazodone
- Triazolam
- Tricyclic antidepressants
- Trimipramine
- Triprolidine
- Zaleplon
- Ziprasidone
- Zolpidem