Capsaicin Metaxalone

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Capsaicin Metaxalone Brand Name– Metaxall CP

What is Capsaicin Metaxalone

Capsaicin metaxalone includes a topical analgesic, capsaicin, and oral central nervous system (CNS) depressant, metaxalone, for the treatment of musculoskeletal pain.

Metaxalone was FDA-approved in August 1962.

Many formulations of capsaicin are available over-the-counter and are used for temporary relief of pain from arthritis, myalgias, arthralgias, and neuralgias.

The most common adverse effects associated with metaxalone and capsaicin are CNS depression- and dermatologic-related with metaxalone and capsaicin, respectively.

Indications

  • musculoskeletal pain

For the treatment of musculoskeletal pain associated with acute, painful musculoskeletal conditions, as an adjunct to rest, physical therapy, and other measures

Side Effects

  1. anaphylactoid reactions
  2. anxiety
  3. burns
  4. contact dermatitis
  5. cough
  6. dizziness
  7. drowsiness
  8. drug-induced body odor
  9. dysgeusia
  10. dyspepsia
  11. ecchymosis
  12. edema
  13. erythema
  14. headache
  15. hemolytic anemia
  16. hyperesthesia
  17. hypoesthesia
  18. irritability
  19. jaundice
  20. leukopenia
  21. maculopapular rash
  22. nasal irritation
  23. nausea
  24. paresthesias
  25. peripheral neuropathy
  26. pharyngitis
  27. pruritus
  28. rash
  29. serotonin syndrome
  30. sinusitis
  31. skin irritation
  32. sneezing
  33. throat irritation
  34. urticaria
  35. vomiting
  36. xerosis

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN

Contraindications

  • accidental exposure
  • anemia
  • breast-feeding
  • driving or operating machinery
  • geriatric
  • heating pad
  • hemolytic anemia
  • hepatic disease
  • hyperglycemia
  • infection
  • inflammation
  • ocular exposure
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • skin abrasion
  • strenuous exercise
  • sunlight (UV) exposure

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Alfentanil
  • Alprazolam
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amobarbital
  • Amoxapine
  • Anxiolytics; Sedatives; and Hypnotics
  • Apomorphine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Bacitracin
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Botulinum Toxins
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cannabidiol
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloral Hydrate
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Clemastine
  • Clomipramine
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclizine
  • Cyproheptadine
  • Desipramine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Diazepam
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Droperidol
  • Entacapone
  • Esketamine
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Fentanyl
  • Flurazepam
  • food
  • Gabapentin
  • General anesthetics
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Imipramine
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levorphanol
  • Lofexidine
  • Lorazepam
  • Loxapine
  • Lumateperone
  • Maprotiline
  • Meclizine
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Methadone
  • Methohexital
  • Methscopolamine
  • Midazolam
  • Mirtazapine
  • Molindone
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nortriptyline
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenothiazines
  • Pregabalin
  • Primidone
  • Protriptyline
  • Quazepam
  • Remifentanil
  • Secobarbital
  • Sedating H1-blockers
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Temazepam
  • Thalidomide
  • Thiopental
  • Thiothixene
  • Tolcapone
  • Tramadol
  • Trazodone
  • Triazolam
  • Tricyclic antidepressants
  • Trimipramine
  • Triprolidine
  • Zaleplon
  • Ziprasidone
  • Zolpidem

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