Mercaptopurine 6 MP

Mercaptopurine 6 MP Brand Names- Purinethol | PURIXAN

What is Mercaptopurine 6 MP

Mercaptopurine is a purine antimetabolite. It is indicated for the treatment of acute lymphocytic/lymphoblastic leukemia as part of a combination regimen.

Mercaptopurine tablets are not indicated for the prophylaxis or treatment of central nervous system leukemia or for the treatment of acute myelogenous leukemia, chronic lymphocytic leukemia, lymphoma, or solid tumors.

Patients with thiopurine S-methyltransferase (TPMT) or nucleotide diphosphatase (NUDT15) deficiency may be at a higher risk for developing mercaptopurine toxicity, especially severe myelosuppression.

Indications

  1. acute lymphocytic leukemia (ALL)
  2. acute myelogenous leukemia (AML)
  3. chronic myelogenous leukemia (CML)
  4. Crohn’s disease
  5. ulcerative colitis

For the treatment of acute lymphocytic leukemia (ALL)

Side Effects

  1. alopecia
  2. anemia
  3. anorexia
  4. ascites
  5. bleeding
  6. cholestasis
  7. diarrhea
  8. elevated hepatic enzymes
  9. fever
  10. hepatic encephalopathy
  11. hepatic necrosis
  12. hepatitis
  13. hepatomegaly
  14. hyperbilirubinemia
  15. hyperuricemia
  16. hypoglycemia
  17. infection
  18. jaundice
  19. lymphoma
  20. lymphopenia
  21. malaise
  22. nausea
  23. neutropenia
  24. new primary malignancy
  25. oligospermia
  26. oral ulceration
  27. pancreatitis
  28. photosensitivity
  29. pulmonary fibrosis
  30. rash
  31. skin cancer
  32. skin hyperpigmentation
  33. spontaneous fetal abortion
  34. thrombocytopenia
  35. tumor lysis syndrome (TLS)
  36. urticaria
  37. vomiting

Monitoring Parameters

  • CBC with differential
  • LFTs
  • pregnancy testing
  • serum creatinine/BUN
  • serum uric acid

Contraindications

  • anemia
  • autoimmune disease
  • bone marrow suppression
  • breast-feeding
  • children
  • contraception requirements
  • hepatic disease
  • hepatotoxicity
  • hypoglycemia
  • immunosuppression
  • infants
  • infection
  • infertility
  • inflammatory bowel disease
  • intrauterine fetal death
  • leukopenia
  • male-mediated teratogenicity
  • neutropenia
  • new primary malignancy
  • nucleotide diphosphatase deficiency
  • pregnancy
  • pregnancy testing
  • renal impairment
  • reproductive risk
  • requires an experienced clinician
  • sunlight (UV) exposure
  • thiopurine methyltransferase deficiency
  • thrombocytopenia
  • tumor lysis syndrome (TLS)
  • vaccination

Interactions

  • Allopurinol
  • Alpha interferons
  • Antithymocyte Globulin
  • Azathioprine
  • Azelastine; Fluticasone
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Balsalazide
  • Basiliximab
  • Beclomethasone
  • Betamethasone
  • Budesonide
  • Budesonide; Formoterol
  • Carbamazepine
  • Ciclesonide
  • Clozapine
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Deflazacort
  • Dexamethasone
  • Doxorubicin
  • Doxorubicin Liposomal
  • Echinacea
  • Efalizumab
  • Febuxostat
  • Filgrastim, G-CSF
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Hydrocortisone
  • Infliximab
  • Influenza Virus Vaccine
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Interferon Alfa-n3
  • Interferon Alfacon-1
  • Intranasal Influenza Vaccine
  • Lesinurad; Allopurinol
  • Live Vaccines
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Mesalamine, 5-ASA
  • Methotrexate
  • Methylprednisolone
  • Mometasone
  • Muromonab-CD3
  • Natalizumab
  • Olsalazine
  • Palifermin
  • Pegfilgrastim
  • Peginterferon Alfa-2a
  • Peginterferon Alfa-2b
  • Penicillamine
  • Pexidartinib
  • Platelet Inhibitors
  • Porfimer
  • Prednisolone
  • Prednisone
  • Riluzole
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Tbo-Filgrastim
  • Tofacitinib
  • Triamcinolone
  • Tuberculin Purified Protein Derivative, PPD
  • Typhoid Vaccine
  • Upadacitinib
  • Varicella-Zoster Virus Vaccine, Live
  • Verteporfin
  • Warfarin
  • Yellow Fever Vaccine, Live