Meprobamate Brand Names- MB-Tab | Miltown
What is Meprobamate
Meprobamate is an oral carbamate derivative used as an anxiolytic.
Meprobamate is similar in structure to carisoprodol; in fact, meprobamate is an active metabolite of carisoprodol.
Meprobamate is indicated for the treatment of anxiety disorders or for the short-term symptomatic treatment of anxiety in adults and children 6 years and older; however, historically the drug has also been used for its sedative properties.
Due to the availability of other therapies, meprobamate is not considered a treatment of choice for anxiety disorders in adults or pediatric patients. Clinical studies evaluating its effectiveness for prolonged therapy (more than 4 months) have not been conducted.
Meprobamate is known to have potential for physical dependence, psychological dependence, and abuse.
Meprobamate was initially marketed in the U.S. in 1955.
Indications
- anxiety
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety
Side Effects
- agranulocytosis
- anaphylactoid reactions
- angioedema
- anorexia
- anuria
- aplastic anemia
- ataxia
- bronchospasm
- bullous rash
- chills
- diarrhea
- dizziness
- drowsiness
- dysarthria
- ecchymosis
- eosinophilia
- erythema multiforme
- euphoria
- exfoliative dermatitis
- fever
- headache
- hypotension
- leukopenia
- maculopapular rash
- nausea
- oliguria
- palpitations
- paresthesias
- peripheral edema
- petechiae
- physiological dependence
- porphyria
- proctitis
- pruritus
- psychological dependence
- purpura
- seizures
- sinus tachycardia
- Stevens-Johnson syndrome
- stomatitis
- syncope
- urticaria
- vertigo
- visual impairment
- vomiting
- weakness
- withdrawal
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- abrupt discontinuation
- alcoholism
- breast-feeding
- carbamate hypersensitivity
- children
- driving or operating machinery
- ethanol intoxication
- geriatric
- hepatic disease
- infants
- neonates
- porphyria
- pregnancy
- renal failure
- renal impairment
- seizure disorder
- seizures
- substance abuse
- suicidal ideation
- tartrazine dye hypersensitivity
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alfentanil
- Alprazolam
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxapine
- Apomorphine
- Apraclonidine
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzodiazepines
- Benztropine
- Brexpiprazole
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorzoxazone
- Clemastine
- Clobazam
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Desipramine
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Diazepam
- Dicyclomine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Enflurane
- Entacapone
- Esketamine
- Estazolam
- Ethanol
- Etomidate
- Ezogabine
- Fenfluramine
- Fentanyl
- Fluoxetine; Olanzapine
- Flurazepam
- Fospropofol
- Gabapentin
- General anesthetics
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Iloperidone
- Imipramine
- Isocarboxazid
- Isoflurane
- Ketamine
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levomethadyl
- Levorphanol
- Lithium
- Lofexidine
- Lorazepam
- Loxapine
- Lumateperone
- Lurasidone
- Maprotiline
- Meclizine
- Melatonin
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Metaxalone
- Methadone
- Methocarbamol
- Methohexital
- Methscopolamine
- Metoclopramide
- Midazolam
- Mirtazapine
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nortriptyline
- Olanzapine
- Orphenadrine
- Oxazepam
- Oxybutynin
- Oxycodone
- Oxymorphone
- Paliperidone
- Papaverine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phentermine; Topiramate
- Pimozide
- Pregabalin
- Primidone
- Propofol
- Propoxyphene
- Protriptyline
- Quazepam
- Quetiapine
- Ramelteon
- Rasagiline
- Remifentanil
- Risperidone
- Ropinirole
- Rotigotine
- Safinamide
- Scopolamine
- Secobarbital
- Sedating H1-blockers
- Selegiline
- Sevoflurane
- Sodium Oxybate
- Sufentanil
- Suvorexant
- Tapentadol
- Temazepam
- Tetrabenazine
- Thalidomide
- Thiopental
- Thiothixene
- Tizanidine
- Tolcapone
- Topiramate
- Tramadol
- Tranylcypromine
- Trazodone
- Triazolam
- Tricyclic antidepressants
- Trihexyphenidyl
- Trimethobenzamide
- Trimipramine
- Triprolidine
- Valerian, Valeriana officinalis
- Vigabatrin
- Vilazodone
- Warfarin
- Ziconotide
- Ziprasidone
