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Mepivacaine Brand Names
Carbocaine | Polocaine | Polocaine MPF
What is Mepivacaine
Mepivacaine is a local anesthetic of the amide type with an intermediate duration of action.
Mepivacaine is used for infiltration and transtracheal anesthesia, and peripheral, sympathetic, regional (Bier’s method), and epidural nerve blocks in surgical and dental procedures.
It is not recommended for subarachnoid use. It is available with and without levonordefrin.
Compared with lidocaine, mepivacaine produces less vasodilation and has a more rapid onset and longer duration of action.
Mepivacaine received FDA approval in 1960.
Indications
- brachial plexus block
- caudal anesthesia
- cervical nerve block
- dental anesthesia
- epidural anesthesia
- infiltration anesthesia
- intercostal nerve block
- local anesthesia
- paracervical block
- pudendal nerve block
- regional anesthesia
- severe pain
Side Effects
- anaphylactoid reactions
- angioedema
- anxiety
- arrhythmia exacerbation
- back pain
- bradycardia
- cardiac arrest
- chondrolysis
- decreased uterine contractility
- diaphoresis
- dizziness
- drowsiness
- dysgeusia
- fecal incontinence
- fetal acidosis
- fetal bradycardia
- fever
- headache
- hypotension
- injection site reaction
- meningitis
- methemoglobinemia
- miosis
- muscle paralysis
- nausea
- neonatal depression
- paresthesias
- pruritus
- rash
- respiratory depression
- restlessness
- seizures
- shivering
- sinus tachycardia
- sneezing
- syncope
- tinnitus
- tremor
- urinary incontinence
- urinary retention
- urticaria
- vomiting
- weakness
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- amide local anesthetic hypersensitivity
- anticoagulant therapy
- AV block
- breast-feeding
- cardiac disease
- coagulopathy
- continuous intraarticular infusion administration
- dehydration
- eclampsia
- fetal distress
- fetal prematurity
- G6PD deficiency
- geriatric
- head and neck anesthesia
- hepatic disease
- hypotension
- hypovolemia
- infants
- infection
- intraarterial administration
- intrathecal administration
- intravenous administration
- labor
- methemoglobinemia
- myasthenia gravis
- neonates
- neurological disease
- obstetric delivery
- ocular surgery
- paraben hypersensitivity
- paracervical nerve block
- pregnancy
- pudendal nerve block
- pulmonary disease
- QT prolongation
- sepsis
- shock
- thrombocytopenia
Interactions
- Acebutolol
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Ambenonium Chloride
- Ambrisentan
- Aminosalicylate sodium, Aminosalicylic acid
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amyl Nitrite
- Articaine; Epinephrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atracurium
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzocaine
- Benzocaine; Butamben; Tetracaine
- Benzonatate
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brimonidine; Timolol
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Caffeine; Ergotamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carteolol
- Carvedilol
- Chloroprocaine
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cholinesterase inhibitors
- Cisatracurium
- Clomipramine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Cyclophosphamide
- Dapsone
- Daratumumab; Hyaluronidase
- Desipramine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxacurium
- Doxepin
- Edrophonium
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Erythromycin; Sulfisoxazole
- Esmolol
- Fentanyl
- Flutamide
- Fosphenytoin
- Galantamine
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyurea
- Ibuprofen; Oxycodone
- Ifosfamide
- Iloprost
- Imipramine
- Isocarboxazid
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Labetalol
- Levomethadyl
- Levorphanol
- Lidocaine
- Lidocaine; Prilocaine
- Magnesium Salts
- Meperidine
- Meperidine; Promethazine
- Methadone
- Methylergonovine
- Methysergide
- Metoclopramide
- Metoprolol
- Minocycline
- Mivacurium
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Neostigmine
- Neuromuscular blockers
- Nitrates
- Nitrofurantoin
- Nitroglycerin
- Nortriptyline
- Oxycodone
- Oxymorphone
- Pancuronium
- Penbutolol
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pergolide
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phenytoin
- Physostigmine
- Pindolol
- Prilocaine
- Prilocaine; Epinephrine
- Primaquine
- Primidone
- Procarbazine
- Propoxyphene
- Propranolol
- Protriptyline
- Pyridostigmine
- Pyrimethamine; Sulfadoxine
- Quinine
- Rapacuronium
- Rasburicase
- Remifentanil
- Rituximab; Hyaluronidase
- Rivastigmine
- Rocuronium
- Ropivacaine
- Succinylcholine
- Sufentanil
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Tacrine
- Tetracaine
- Timolol
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Tricyclic antidepressants
- Trimipramine
- Tubocurarine
- Valproic Acid, Divalproex Sodium
- Vecuronium