Mepivacaine and Levonordefrin

Mepivacaine and Levonordefrin Brand Names- Carbocaine with Neo-Cobefrin | Polocaine with Levonodefrin

What is Mepivacaine and Levonordefrin

Mepivacaine and levonordefrin are used together in a parenteral preparation for local anesthesia in dental procedures.

Mepivacaine is an amide local anesthetic with an intermediate duration of action.

Levonordefrin is a vasoconstrictor and is used to promote local hemostasis, and to decrease systemic absorption and prolong duration of action of the local anesthetics.

Mepivacaine and levonordefrin was approved by the FDA for dental anesthesia  in January 1976.

Indications

  • dental anesthesia
  • infiltration anesthesia
  • local anesthesia

For local anesthesia in dentistry (dental anesthesia) including inferior alveolar nerve block and maxillary infiltration anesthesia

Side Effects

  1. anaphylactoid reactions
  2. blurred vision
  3. diaphoresis
  4. dizziness
  5. drowsiness
  6. edema
  7. hypoxia
  8. paresthesias
  9. respiratory arrest
  10. seizures
  11. tremor
  12. urticaria

Contraindications

  • amide local anesthetic hypersensitivity
  • asthma
  • AV block
  • breast-feeding
  • cardiac disease
  • cerebrovascular disease
  • children
  • coronary artery disease
  • diabetes mellitus
  • G6PD deficiency
  • geriatric
  • hepatic disease
  • hypertension
  • infants
  • intraarterial administration
  • intravenous administration
  • MAOI therapy
  • methemoglobinemia
  • neonates
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • sulfite hypersensitivity
  • thyrotoxicosis

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Albiglutide
  • Alfentanil
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Ambenonium Chloride
  • Ambrisentan
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amyl Nitrite
  • Articaine; Epinephrine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
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  • Belladonna; Opium
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  • Brompheniramine; Hydrocodone; Pseudoephedrine
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  • Caffeine; Ergotamine
  • Canagliflozin
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  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cholinesterase inhibitors
  • Cisatracurium
  • Clomipramine
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
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  • Dorzolamide; Timolol
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  • Dulaglutide
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Edrophonium
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Epoprostenol
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  • Ergonovine
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  • Glimepiride; Rosiglitazone
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  • Hydrochlorothiazide, HCTZ; Metoprolol
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  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
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