Magnesium Salicylate

Magnesium Salicylate Brand Names

Doans | Masalate | MST 600 | Novasal | Percogesic Backache Relief

What is Magnesium Salicylate

Magnesium salicylate is an oral salicylic acid derivative. It is used for the control of pain and as an anti-inflammatory agent.

Magnesium salicylate is a sodium-free, non-acetylated salicylate. It has a low incidence of GI side effects and does not have a clinically significant effect on platelet function.

Special care should be used in patients with renal disease due to the magnesium content.

Magnesium salicylate products have been available prior to the formation of the FDA in 1938.

Indications

1. arthralgia
2. bone pain
3. bursitis
4. dental pain
5. dysmenorrhea
6. fever
7. headache
8. juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
9. mild pain
10. moderate pain
11. myalgia
12. osteoarthritis
13. rheumatoid arthritis
14. tendinitis

For the treatment of fever or mild pain and moderate pain (e.g., arthralgia, bone pain, dental pain, dysmenorrhea, headache, or myalgia

Side Effects

1. abdominal pain
2. acneiform rash
3. agranulocytosis
4. anaphylactoid reactions
5. angioedema
6. aplastic anemia
7. azotemia
8. bronchospasm
9. confusion
10. constipation
11. dehydration
12. diaphoresis
13. diarrhea
14. disseminated intravascular coagulation (DIC)
15. dizziness
16. drowsiness
17. elevated hepatic enzymes
18. encephalopathy
19. erythema nodosum
20. fever
21. gastritis
22. GI bleeding
23. hallucinations
24. headache
25. hearing loss
26. hepatic necrosis
27. hepatitis
28. hyperbilirubinemia
29. hyperglycemia
30. hypermagnesemia
31. hypernatremia
32. hyperuricemia
33. hyperventilation
34. hypoglycemia
35. hypokalemia
36. hypoprothrombinemia
37. jaundice
38. lethargy
39. leukocytosis
40. leukopenia
41. maculopapular rash
42. metabolic acidosis
43. nausea
44. pancytopenia
45. peptic ulcer
46. proteinuria
47. pruritus
48. pulmonary edema
49. purpura
50. pyrosis (heartburn)
51. renal papillary necrosis
52. renal tubular necrosis
53. respiratory depression
54. Reye’s syndrome
55. seizures
56. thrombocytopenia
57. tinnitus
58. urticaria
59. visual impairment
60. vomiting
61. wheezing

Monitoring Parameters

• glucose-6-phosphate dehydrogenase (G6PD) activity
• LFTs
• serum creatinine/BUN
• serum magnesium
• serum salicylate concentrations

Contraindications

• acid/base imbalance
• acute bronchospasm
• alcoholism
• anemia
• anticoagulant therapy
• ascites
• bone marrow suppression
• breast-feeding
• coagulopathy
• dehydration
• esophagitis
• G6PD deficiency
• gastritis
• geriatric
• GI bleeding
• GI disease
• gout
• heart failure
• hemophilia
• hepatic disease
• hypermagnesemia
• hypertension
• hypoprothrombinemia
• hypovolemia
• immunosuppression
• influenza
• labor
• metabolic acidosis
• metabolic alkalosis
• nasal polyps
• neutropenia
• NSAID hypersensitivity
• peptic ulcer disease
• pregnancy
• renal disease
• renal failure
• renal impairment
• respiratory acidosis
• respiratory alkalosis
• Reye’s syndrome
• salicylate hypersensitivity
• systemic lupus erythematosus (SLE)
• thrombolytic therapy
• thrombotic thrombocytopenic purpura (TTP)
• tobacco smoking
• varicella
• viral infection
• vitamin K deficiency

Interactions

• Acetaminophen
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acetazolamide
• Acetohexamide
• Acidifying Agents
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alkalinizing Agents
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminoglycosides
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amphotericin B
• Amphotericin B cholesteryl sulfate complex (ABCD)
• Amphotericin B lipid complex (ABLC)
• Amphotericin B liposomal (LAmB)
• Angiotensin-converting enzyme inhibitors
• Antithrombin III
• Antithymocyte Globulin
• Apixaban
• Ardeparin
• Ascorbic Acid, Vitamin C
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Atenolol; Chlorthalidone
• Azilsartan; Chlorthalidone
• Bacitracin
• Barbiturates
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Beta-blockers
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bromocriptine
• Bumetanide
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Capreomycin
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Cefdinir
• Cefixime
• Cefotetan
• Celecoxib
• Chlorothiazide
• Chlorpropamide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Cidofovir
• Ciprofloxacin
• Citalopram
• Citric Acid; Potassium Citrate
• Citric Acid; Potassium Citrate; Sodium Citrate
• Citric Acid; Sodium Citrate
• Colchicine; Probenecid
• Colistimethate, Colistin, Polymyxin E
• Corticosteroids
• Cyclosporine
• Dabigatran
• Dalteparin
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Daratumumab; Hyaluronidase
• Deferasirox
• Delafloxacin
• Dichlorphenamide
• Diclofenac
• Diclofenac; Misoprostol
• Diflunisal
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Doravirine; Lamivudine; Tenofovir disoproxil fumarate
• Drotrecogin Alfa
• Edoxaban
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Emtricitabine; Tenofovir disoproxil fumarate
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enoxaparin
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Escitalopram
• Esomeprazole; Naproxen
• Ethacrynic Acid
• Ethanol
• Ethotoin
• Etodolac
• Famotidine; Ibuprofen
• Fenoprofen
• Flavocoxid, Flavocoxid; Citrated Zinc Bisglycinate
• Fluoxetine
• Fluoxetine; Olanzapine
• Flurbiprofen
• Fluvoxamine
• Fondaparinux
• Foscarnet
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Furosemide
• Gallium Ga 68 Dotatate
• Gemifloxacin
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Griseofulvin
• Heparin
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Ibuprofen
• Ibritumomab Tiuxetan
• Ibuprofen
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Immune Globulin IV, IVIG, IGIV
• Incretin Mimetics
• Indapamide
• Indomethacin
• Inotersen
• Insulins
• Ketoprofen
• Ketorolac
• Lamivudine; Tenofovir Disoproxil Fumarate
• Lansoprazole; Naproxen
• Levofloxacin
• Linagliptin
• Linagliptin; Metformin
• Lisinopril
• Loop diuretics
• Low Molecular Weight Heparins
• Macimorelin
• Magnesium Citrate
• Mannitol
• Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
• Meclofenamate Sodium
• Mefenamic Acid
• Meglitinides
• Meloxicam
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methazolamide
• Methotrexate
• Methyclothiazide
• Metolazone
• Moexipril
• Moxifloxacin
• Mycophenolate
• Nabumetone
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nateglinide
• Nitazoxanide
• Norfloxacin
• Ofloxacin
• Omeprazole; Sodium Bicarbonate
• Oxaprozin
• Paroxetine
• Penicillins
• Pentosan
• Perindopril
• Perindopril; Amlodipine
• Phentermine; Topiramate
• Phenytoin
• Photosensitizing agents (topical)
• Pioglitazone
• Piroxicam
• Polymyxins
• Potassium Bicarbonate
• Potassium Chloride
• Potassium Citrate
• Pramlintide
• Probenecid
• Psyllium
• Quinapril
• Ramipril
• Repaglinide
• Rituximab; Hyaluronidase
• Rivaroxaban
• Rosiglitazone
• Salicylic Acid
• Saxagliptin
• Selective serotonin reuptake inhibitors
• Serotonin norepinephrine reuptake inhibitors
• Sertraline
• Simvastatin; Sitagliptin
• Sitagliptin
• Sodium Bicarbonate
• Sodium Hyaluronate, Hyaluronic Acid
• Sodium Lactate
• Sodium Thiosulfate; Salicylic Acid
• Spironolactone
• Sulfinpyrazone
• Sulfonamides
• Sulfonylureas
• Sulindac
• Tacrolimus
• Telavancin
• Tenofovir Alafenamide
• Tenofovir, PMPA
• Thiazide diuretics
• Thiazolidinediones
• Thrombin Inhibitors
• Thrombolytic Agents
• Tinzaparin
• Tolazamide
• Tolbutamide
• Tolmetin
• Topiramate
• Torsemide
• Trandolapril
• Trandolapril; Verapamil
• Trastuzumab; Hyaluronidase
• Trazodone
• Treprostinil
• Triamterene
• Tromethamine
• Valproic Acid, Divalproex Sodium
• Vancomycin
• Varicella-Zoster Virus Vaccine, Live
• Vilazodone
• Vortioxetine
• Warfarin